KAT8 and ATM

Number of citations of the paper that reports this interaction (PMID 15923642)
63

Data Source:
BioGRID (pull down)

		KAT8	ATM
Gene Name		K(lysine) acetyltransferase 8	ATM serine/threonine kinase
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Histone Acetyltransferase Complex Kinetochore Nucleus Nucleoplasm Nuclear Membrane MLL1 Complex MSL Complex	Chromosome, Telomeric Region Nucleoplasm Spindle Cytoplasmic Membrane-bounded Vesicle
	Molecular Function	Histone Acetyltransferase Activity Protein Binding Transcription Factor Binding Acetyltransferase Activity Enzyme Binding Methylated Histone Binding Histone Acetyltransferase Activity (H4-K5 Specific) Histone Acetyltransferase Activity (H4-K8 Specific) Metal Ion Binding Histone Acetyltransferase Activity (H4-K16 Specific)	DNA Binding Protein Serine/threonine Kinase Activity DNA-dependent Protein Kinase Activity Protein Binding ATP Binding 1-phosphatidylinositol-3-kinase Activity Protein Complex Binding Histone Serine Kinase Activity Protein Dimerization Activity Protein N-terminus Binding
	Biological Process	Chromatin Organization Transcription, DNA-templated Regulation Of Autophagy Histone Acetylation Myeloid Cell Differentiation Histone H4-K5 Acetylation Histone H4-K8 Acetylation Histone H4-K16 Acetylation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated	Telomere Maintenance Double-strand Break Repair Via Homologous Recombination Response To Hypoxia Somitogenesis Pre-B Cell Allelic Exclusion DNA Repair Double-strand Break Repair Protein Phosphorylation Cellular Response To DNA Damage Stimulus DNA Damage Induced Protein Phosphorylation DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Cell Cycle Arrest Mitotic Spindle Assembly Checkpoint Reciprocal Meiotic Recombination Signal Transduction Brain Development Heart Development Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Response To Ionizing Radiation Peptidyl-serine Phosphorylation Negative Regulation Of B Cell Proliferation V(D)J Recombination Cellular Response To Heat Histone-serine Phosphorylation Phosphatidylinositol-3-phosphate Biosynthetic Process Lipoprotein Catabolic Process Positive Regulation Of Apoptotic Process Positive Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Positive Regulation Of Neuron Apoptotic Process Protein Autophosphorylation Oocyte Development Neuron Apoptotic Process Histone MRNA Catabolic Process Cellular Response To Gamma Radiation Signal Transduction Involved In Mitotic G2 DNA Damage Checkpoint Replicative Senescence Regulation Of Cellular Response To Heat
Pathways		Chromatin modifying enzymes Chromatin organization HATs acetylate histones	Ubiquitin Mediated Degradation of Phosphorylated Cdc25A Fanconi Anemia pathway G2/M Checkpoints Cellular Senescence p53-Dependent G1/S DNA damage checkpoint p53-Dependent G1 DNA Damage Response Regulation of the Fanconi anemia pathway Stabilization of p53 p53-Independent DNA Damage Response Homologous recombination repair of replication-independent double-strand breaks p53-Independent G1/S DNA damage checkpoint Double-Strand Break Repair G1/S DNA Damage Checkpoints ATM mediated phosphorylation of repair proteins DNA Damage/Telomere Stress Induced Senescence Meiotic recombination ATM mediated response to DNA double-strand break G2/M DNA damage checkpoint Regulation of HSF1-mediated heat shock response Cellular response to heat stress Autodegradation of the E3 ubiquitin ligase COP1 Homologous Recombination Repair Recruitment of repair and signaling proteins to double-strand breaks Cell Cycle Checkpoints
Drugs
Diseases
GWAS			Melanoma ( 21983787) Response to metformin ( 21186350 21845381)
Protein-Protein Interactions		11 interactors: ATM BAZ2A FOXP3 HIST1H4A KANSL1 KMT2A MSL1 MSL3 PAF1 RNF2 TP53	76 interactors: AATF ABL1 AP1B1 AP2A2 AP2B1 AP3B2 ATR BCL10 BLM BRCA1 BRCA2 CDC6 CDKN2C CHD4 CHEK1 CHEK2 CREB1 CSNK1D CXXC5 DAXX DCLRE1C DDX1 DYRK2 E2F1 E4F1 EEF1E1 EIF3E EIF4EBP1 EXO1 FANCD2 FOXO3 H2AFX HIF1A KAT5 KAT8 LIG4 MCM2 MDC1 MDM2 MDM4 MRE11A NBN PARP1 PEX5 POLR2A PRKDC PTS RAD17 RAD51 RAD9A RBBP8 RHEB RNF20 RNF40 RPA1 RPA2 SMC1A SOCS1 SPSB1 STK11 TCL1A TELO2 TERF1 TERF2 TIPARP TOP1 TOPBP1 TP53 TP53BP1 TRAF6 TREX1 VPRBP WRN XPA XRCC5 ZEB1
Entrez ID		84148	472
HPRD ID		11381	06347
Ensembl ID		ENSG00000103510	ENSG00000149311
Uniprot IDs		Q9H7Z6	Q13315
PDB IDs		2GIV 2PQ8 2Y0M 3QAH 3TOA 3TOB 4DNC
Enriched GO Terms of Interacting Partners?		Chromatin Organization Chromosome Organization Chromatin Modification Histone Modification Histone H4-K16 Acetylation Organelle Organization Histone H4 Acetylation Peptidyl-lysine Modification Histone Acetylation Internal Peptidyl-lysine Acetylation Peptidyl-lysine Acetylation Internal Protein Amino Acid Acetylation Protein Acetylation Cellular Protein Modification Process Peptidyl-amino Acid Modification Regulation Of Chromosome Organization DNA Methylation Negative Regulation Of Transcription, DNA-templated Anterior/posterior Pattern Specification Negative Regulation Of Nucleic Acid-templated Transcription Positive Regulation Of Histone Modification Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Cell Proliferation DNA Modification Replicative Senescence Cellular Protein Metabolic Process Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Chromatin Silencing At RDNA Transcription, DNA-templated Negative Regulation Of Immune System Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Gene Expression Regulation Of Histone Modification RNA Biosynthetic Process Regulation Of Gene Expression Chromatin Assembly Cellular Nitrogen Compound Metabolic Process Histone Monoubiquitination Chromatin Assembly Or Disassembly Pattern Specification Process DNA Metabolic Process Nitrogen Compound Metabolic Process Protein Metabolic Process Chromatin Remodeling DNA Packaging	Cellular Response To DNA Damage Stimulus Cellular Response To Stress DNA Metabolic Process DNA Repair Double-strand Break Repair Cell Cycle Process Cell Cycle Response To Stress DNA Recombination Response To Ionizing Radiation Cell Cycle Checkpoint DNA Damage Checkpoint DNA Replication Response To Radiation Chromosome Organization Double-strand Break Repair Via Homologous Recombination Recombinational Repair Heterocycle Metabolic Process Nucleobase-containing Compound Metabolic Process Cellular Aromatic Compound Metabolic Process Negative Regulation Of Cell Cycle Mitotic Cell Cycle Process Regulation Of Mitotic Cell Cycle Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Biosynthetic Process Mitotic Cell Cycle Regulation Of Cell Cycle Nitrogen Compound Metabolic Process Response To Abiotic Stimulus Cellular Response To Stimulus Negative Regulation Of DNA Replication Negative Regulation Of Cellular Metabolic Process Telomere Maintenance Signal Transduction In Response To DNA Damage Negative Regulation Of DNA Metabolic Process Organelle Organization Negative Regulation Of Mitotic Cell Cycle Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Response To Stimulus Mitotic Cell Cycle Checkpoint Regulation Of DNA Replication Cellular Metabolic Process Signal Transduction By P53 Class Mediator Apoptotic Signaling Pathway Mitotic DNA Damage Checkpoint Mitotic DNA Integrity Checkpoint Regulation Of Nitrogen Compound Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Cellular Metabolic Process
Tagcloud ?		acetylated acetylation acetyltransferase acetyltransferases alter broad compaction compensation decompact dosage embryonic enhancers ep300 escs flies h3k27 h3k4me1 h4 h4k16 h4k16ac histone interest marked marks nucleosomes peaks start surprisingly tails	absent alpha ataxia basis cytokines defective degradation fibroblasts fully ikappab immunoprecipitated induces ionizing kappab mediates mitogens nf oxidants oxidative product radiation rapid restores stimuli stresses telangiectasia tnf transfected understood
Tagcloud (Difference) ?		acetylated acetylation acetyltransferase acetyltransferases alter broad compaction compensation decompact dosage embryonic enhancers ep300 escs flies h3k27 h3k4me1 h4 h4k16 h4k16ac histone interest marked marks nucleosomes peaks start surprisingly tails	absent alpha ataxia basis cytokines defective degradation fibroblasts fully ikappab immunoprecipitated induces ionizing kappab mediates mitogens nf oxidants oxidative product radiation rapid restores stimuli stresses telangiectasia tnf transfected understood
Tagcloud (Intersection) ?