KAT8 and BAZ1B

Number of citations of the paper that reports this interaction (PubMedID 32518374)
0

Data Source:
BioGRID (enzymatic study)

		KAT8	BAZ1B
Description		lysine acetyltransferase 8	bromodomain adjacent to zinc finger domain 1B
Image
GO Annotations	Cellular Component	Histone Acetyltransferase Complex Kinetochore Nucleus Nucleoplasm Chromosome Mitochondrion Nuclear Matrix Nuclear Lumen NuA4 Histone Acetyltransferase Complex NSL Complex MLL1 Complex MSL Complex	Chromatin Condensed Chromosome Nucleus Nucleoplasm Pericentric Heterochromatin Nucleolus Nuclear Replication Fork WICH Complex B-WICH Complex
	Molecular Function	Transcription Coactivator Activity Histone Acetyltransferase Activity Protein Binding Zinc Ion Binding Histone H4 Acetyltransferase Activity Acetyltransferase Activity Transferase Activity Acyltransferase Activity Enzyme Binding Histone H4K5 Acetyltransferase Activity Histone H4K8 Acetyltransferase Activity Metal Ion Binding Histone H4K16 Acetyltransferase Activity RNA Polymerase II-specific DNA-binding Transcription Factor Binding Protein-lysine-acetyltransferase Activity Protein Propionyltransferase Activity DNA-binding Transcription Factor Binding Promoter-specific Chromatin Binding	Nucleotide Binding Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Protein Binding ATP Binding Zinc Ion Binding Kinase Activity Transferase Activity Histone Kinase Activity Histone Binding Metal Ion Binding Histone H2AXY142 Kinase Activity
	Biological Process	Epithelial To Mesenchymal Transition Chromatin Organization Regulation Of DNA-templated Transcription Dosage Compensation By Inactivation Of X Chromosome Regulation Of Autophagy Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Epithelial To Mesenchymal Transition Negative Regulation Of Epithelial To Mesenchymal Transition Skeletal Muscle Satellite Cell Differentiation Neurogenesis Hemopoiesis Myeloid Cell Differentiation Negative Regulation Of Type I Interferon Production Positive Regulation Of Type I Interferon Production Post-embryonic Hemopoiesis Epigenetic Regulation Of Gene Expression Regulation Of Cell Differentiation Transcription Initiation-coupled Chromatin Remodeling Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Oogenesis Regulation Of MRNA Processing Negative Regulation Of Multicellular Organismal Process Positive Regulation Of Transcription Initiation By RNA Polymerase II Membraneless Organelle Assembly Positive Regulation Of Skeletal Muscle Satellite Cell Differentiation Regulation Of Mitochondrial Transcription	Chromatin Organization Chromatin Remodeling Regulation Of Transcription By RNA Polymerase II DNA Damage Response Post-translational Protein Modification Positive Regulation Of Transcription By RNA Polymerase I Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase III Negative Regulation Of Mitotic Chromosome Condensation
Pathways		HATs acetylate histones Formation of WDR5-containing histone-modifying complexes	B-WICH complex positively regulates rRNA expression Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Drugs
Diseases
GWAS		Alzheimer's disease or family history of Alzheimer's disease ( 30617256) Bipolar disorder ( 31043756) Bipolar I disorder ( 31043756) Body mass index ( 25673413) Family history of Alzheimer's disease ( 30617256) Parkinson's disease ( 28892059) Triglyceride levels ( 32154731)	C-reactive protein levels or HDL-cholesterol levels (pleiotropy) ( 27286809) Hip index ( 34021172) Hypertriglyceridemia ( 23505323) Hyperuricemia ( 29124443) Lamb consumption ( 32066663) Lipoprotein (a) levels ( 33730874) Malaria ( 31844061) Meat-related diet ( 32066663) Metabolic syndrome ( 31589552) Migraine ( 27182965) Non-oily fish consumption ( 32066663) Platelet count ( 32888494) Protein C levels ( 20802025) Pursuit maintenance gain ( 29064472) Serum alkaline phosphatase levels ( 33339817) Serum uric acid levels ( 30993211) Triglyceride levels ( 32203549) Triglyceride levels x fish oil supplementation interaction (2df) ( 33760818) Triglycerides ( 20864672) Urate levels ( 31985003 23263486) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172) Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction) ( 28448500) Waist-to-hip ratio adjusted for body mass index ( 28448500)
Interacting Genes		15 interacting genes: ATM BAZ1B BAZ2A CEBPA FOXP3 H2AC8 H3C1 H4C1 H4C7 KMT2A PAF1 PLAU RNF2 TP53 TP53BP1	16 interacting genes: CDT1 H2AX KANSL1 KAT8 MAILR MTNR1A MYO1C NR4A2 PCNA RNF10 SIRT1 SMARCA1 SMARCA5 SMARCC2 SMARCE1 SUMO2
Entrez ID		84148	9031
HPRD ID		11381	10416
Ensembl ID		ENSG00000103510	ENSG00000009954
Uniprot IDs		Q9H7Z6	Q9UIG0
PDB IDs		2GIV 2PQ8 2Y0M 3QAH 3TOA 3TOB 4DNC 5H43 5J8C 5J8F 5WCI 6BA2 6BA4 6CT2 6OIN 6OIO 6OIP 6OIQ 6OIR 6OWH 6OWI 6PD8 6PD9 6PDA 6PDB 6PDC 6PDD 6PDE 6PDF 6PDG 7CMR 8W13	1F62 5NNF
Enriched GO Terms of Interacting Partners?		Chromatin Remodeling Chromatin Organization DNA Binding Epigenetic Regulation Of Gene Expression Response To X-ray Regulation Of Gene Expression Positive Regulation Of Transcription By RNA Polymerase II Protein Heterodimerization Activity Structural Constituent Of Chromatin Regulation Of Macromolecule Biosynthetic Process Protein Localization To Chromosome Nucleosome Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA Metabolic Process Chromosome Negative Regulation Of DNA Recombination Negative Regulation Of Cell Population Proliferation Cellular Response To X-ray Positive Regulation Of RNA Biosynthetic Process Regulation Of Macromolecule Metabolic Process Regulation Of Transcription By RNA Polymerase II Positive Regulation Of DNA-templated Transcription Regulation Of RNA Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Cell Cycle Cellular Response To Ionizing Radiation Positive Regulation Of RNA Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Protein-DNA Complex Assembly DNA Repair Complex DNA Strand Resection Involved In Replication Fork Processing Negative Regulation Of Chromosome Organization Replicative Senescence Negative Regulation Of Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Protein Localization To Organelle Negative Regulation Of Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Gene Expression CENP-A Containing Nucleosome Protein Localization To CENP-A Containing Chromatin Regulation Of Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Hematopoietic Or Lymphoid Organ Development Site Of Double-strand Break DNA Damage Checkpoint Signaling Alpha-beta T Cell Activation Regulation Of Cell Population Proliferation Regulation Of Integrin-mediated Signaling Pathway	Positive Regulation Of Nucleobase-containing Compound Metabolic Process Chromatin Organization Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of DNA Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of Nucleobase-containing Compound Metabolic Process Chromatin Remodeling Positive Regulation Of RNA Metabolic Process Regulation Of DNA Metabolic Process Positive Regulation Of DNA Repair Heterochromatin Formation Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Kinetochore Negative Regulation Of Gene Expression, Epigenetic Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Nucleoplasm Regulation Of Primary Metabolic Process Positive Regulation Of Double-strand Break Repair Chromatin Regulation Of DNA Repair Regulation Of RNA Metabolic Process Epigenetic Regulation Of Gene Expression CERF Complex Nucleosome Organization Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Macromolecule Metabolic Process Positive Regulation Of DNA Replication Nucleosome Array Spacer Activity Regulation Of Double-strand Break Repair Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Histone Binding NURF Complex RDNA Heterochromatin Formation Negative Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Chromosome B-WICH Complex Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Cell Cycle Process Negative Regulation Of Metabolic Process BBAF Complex Regulation Of Mitochondrial Transcription Negative Regulation Of Macromolecule Biosynthetic Process Chromatin Silencing Complex
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