KAT8 and BAZ2A

Number of citations of the paper that reports this interaction (PMID 19578370)
19

Data Source:
BioGRID (enzymatic study, affinity chromatography technology)

		KAT8	BAZ2A
Gene Name		K(lysine) acetyltransferase 8	bromodomain adjacent to zinc finger domain, 2A
Image
Gene Ontology Annotations	Cellular Component	Histone Acetyltransferase Complex Kinetochore Nucleus Nucleoplasm Nuclear Membrane MLL1 Complex MSL Complex	Chromatin Silencing Complex Nucleolus RDNA Heterochromatin
	Molecular Function	Histone Acetyltransferase Activity Protein Binding Transcription Factor Binding Acetyltransferase Activity Enzyme Binding Methylated Histone Binding Histone Acetyltransferase Activity (H4-K5 Specific) Histone Acetyltransferase Activity (H4-K8 Specific) Metal Ion Binding Histone Acetyltransferase Activity (H4-K16 Specific)	DNA Binding RNA Binding Protein Binding Zinc Ion Binding Ligand-dependent Nuclear Receptor Binding Lysine-acetylated Histone Binding
	Biological Process	Chromatin Organization Transcription, DNA-templated Regulation Of Autophagy Histone Acetylation Myeloid Cell Differentiation Histone H4-K5 Acetylation Histone H4-K8 Acetylation Histone H4-K16 Acetylation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated	Chromatin Silencing At RDNA DNA Methylation Chromatin Remodeling Transcription, DNA-templated Regulation Of Transcription, DNA-templated Gene Expression Histone Deacetylation Histone H4-K20 Methylation Regulation Of Gene Expression, Epigenetic Negative Regulation Of Gene Expression, Epigenetic Histone H3-K9 Methylation Heterochromatin Assembly Involved In Chromatin Silencing Histone H4 Deacetylation
Pathways		Chromatin modifying enzymes Chromatin organization HATs acetylate histones	NoRC negatively regulates rRNA expression Epigenetic regulation of gene expression Negative epigenetic regulation of rRNA expression
Drugs
Diseases
GWAS			Mean platelet volume ( 22139419) Platelet counts ( 22139419)
Protein-Protein Interactions		11 interactors: ATM BAZ2A FOXP3 HIST1H4A KANSL1 KMT2A MSL1 MSL3 PAF1 RNF2 TP53	7 interactors: DNMT1 DNMT3B HDAC1 HIST1H4A KAT8 SMARCA5 TTF1
Entrez ID		84148	11176
HPRD ID		11381	10417
Ensembl ID		ENSG00000103510	ENSG00000076108
Uniprot IDs		Q9H7Z6	F8VU39 J3KPG5 Q9UIF9
PDB IDs		2GIV 2PQ8 2Y0M 3QAH 3TOA 3TOB 4DNC	4LZ2
Enriched GO Terms of Interacting Partners?		Chromatin Organization Chromosome Organization Chromatin Modification Histone Modification Histone H4-K16 Acetylation Organelle Organization Histone H4 Acetylation Peptidyl-lysine Modification Histone Acetylation Internal Peptidyl-lysine Acetylation Peptidyl-lysine Acetylation Internal Protein Amino Acid Acetylation Protein Acetylation Cellular Protein Modification Process Peptidyl-amino Acid Modification Regulation Of Chromosome Organization DNA Methylation Negative Regulation Of Transcription, DNA-templated Anterior/posterior Pattern Specification Negative Regulation Of Nucleic Acid-templated Transcription Positive Regulation Of Histone Modification Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Cell Proliferation DNA Modification Replicative Senescence Cellular Protein Metabolic Process Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Chromatin Silencing At RDNA Transcription, DNA-templated Negative Regulation Of Immune System Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Gene Expression Regulation Of Histone Modification RNA Biosynthetic Process Regulation Of Gene Expression Chromatin Assembly Cellular Nitrogen Compound Metabolic Process Histone Monoubiquitination Chromatin Assembly Or Disassembly Pattern Specification Process DNA Metabolic Process Nitrogen Compound Metabolic Process Protein Metabolic Process Chromatin Remodeling DNA Packaging	Negative Regulation Of Gene Expression, Epigenetic Regulation Of Gene Expression, Epigenetic Chromatin Modification Chromatin Organization Chromosome Organization Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process DNA Methylation On Cytosine Gene Silencing Negative Regulation Of Cellular Metabolic Process Chromatin Silencing Chromatin Remodeling C-5 Methylation Of Cytosine DNA Methylation ATP-dependent Chromatin Remodeling Organelle Organization Gene Expression DNA Modification Negative Regulation Of Histone H3-K9 Methylation Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Histone H3-K4 Methylation Chromatin Silencing At RDNA Regulation Of RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Negative Regulation Of Histone Methylation Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Regulation Of Histone H3-K4 Methylation Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Gene Expression CENP-A Containing Nucleosome Assembly DNA-templated Transcription, Initiation Negative Regulation Of Transcription From RNA Polymerase II Promoter Nitrogen Compound Metabolic Process Histone Exchange DNA Replication-independent Nucleosome Assembly Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Histone Methylation Centromere Complex Assembly Regulation Of Histone Methylation DNA Metabolic Process Cellular Response To Amino Acid Stimulus Histone Modification
Tagcloud ?		acetylated acetylation acetyltransferase acetyltransferases alter broad compaction compensation decompact dosage embryonic enhancers ep300 escs flies h3k27 h3k4me1 h4 h4k16 h4k16ac histone interest marked marks nucleosomes peaks start surprisingly tails	bc bladder characterizing fgfr3 formulation lowered messenger micrornas mir mirna mtor oncogenes oncogenesis oncomir ploidy promoted promoting qrt representative respective rnas rt4 smarca5 supposed t24 thap2 today transfection urothelial
Tagcloud (Difference) ?		acetylated acetylation acetyltransferase acetyltransferases alter broad compaction compensation decompact dosage embryonic enhancers ep300 escs flies h3k27 h3k4me1 h4 h4k16 h4k16ac histone interest marked marks nucleosomes peaks start surprisingly tails	bc bladder characterizing fgfr3 formulation lowered messenger micrornas mir mirna mtor oncogenes oncogenesis oncomir ploidy promoted promoting qrt representative respective rnas rt4 smarca5 supposed t24 thap2 today transfection urothelial
Tagcloud (Intersection) ?