KAT8 and H4C7

Number of citations of the paper that reports this interaction (PubMedID 35907431)
0

Data Source:
BioGRID (enzymatic study)

		KAT8	H4C7
Description		lysine acetyltransferase 8	H4 clustered histone 7
Image			No pdb structure
GO Annotations	Cellular Component	Histone Acetyltransferase Complex Kinetochore Nucleus Nucleoplasm Chromosome Mitochondrion Nuclear Matrix Nuclear Lumen NuA4 Histone Acetyltransferase Complex NSL Complex MLL1 Complex MSL Complex	Nucleosome Nucleus Chromosome
	Molecular Function	Transcription Coactivator Activity Histone Acetyltransferase Activity Protein Binding Zinc Ion Binding Histone H4 Acetyltransferase Activity Acetyltransferase Activity Transferase Activity Acyltransferase Activity Enzyme Binding Histone H4K5 Acetyltransferase Activity Histone H4K8 Acetyltransferase Activity Metal Ion Binding Histone H4K16 Acetyltransferase Activity RNA Polymerase II-specific DNA-binding Transcription Factor Binding Protein-lysine-acetyltransferase Activity Protein Propionyltransferase Activity DNA-binding Transcription Factor Binding Promoter-specific Chromatin Binding	DNA Binding Protein Binding Structural Constituent Of Chromatin Protein Heterodimerization Activity
	Biological Process	Epithelial To Mesenchymal Transition Chromatin Organization Regulation Of DNA-templated Transcription Dosage Compensation By Inactivation Of X Chromosome Regulation Of Autophagy Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Epithelial To Mesenchymal Transition Negative Regulation Of Epithelial To Mesenchymal Transition Skeletal Muscle Satellite Cell Differentiation Neurogenesis Hemopoiesis Myeloid Cell Differentiation Negative Regulation Of Type I Interferon Production Positive Regulation Of Type I Interferon Production Post-embryonic Hemopoiesis Epigenetic Regulation Of Gene Expression Regulation Of Cell Differentiation Transcription Initiation-coupled Chromatin Remodeling Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Oogenesis Regulation Of MRNA Processing Negative Regulation Of Multicellular Organismal Process Positive Regulation Of Transcription Initiation By RNA Polymerase II Membraneless Organelle Assembly Positive Regulation Of Skeletal Muscle Satellite Cell Differentiation Regulation Of Mitochondrial Transcription	Nucleosome Assembly
Pathways		HATs acetylate histones Formation of WDR5-containing histone-modifying complexes
Drugs
Diseases
GWAS		Alzheimer's disease or family history of Alzheimer's disease ( 30617256) Bipolar disorder ( 31043756) Bipolar I disorder ( 31043756) Body mass index ( 25673413) Family history of Alzheimer's disease ( 30617256) Parkinson's disease ( 28892059) Triglyceride levels ( 32154731)
Interacting Genes		15 interacting genes: ATM BAZ1B BAZ2A CEBPA FOXP3 H2AC8 H3C1 H4C1 H4C7 KMT2A PAF1 PLAU RNF2 TP53 TP53BP1	13 interacting genes: AGTRAP APOC1 CIDEB EP300 FGF14 FKBP7 KAT2A KAT8 KMT5B KMT5C MAIP1 RHBDD2 TMED8
Entrez ID		84148	8369
HPRD ID		11381	11806
Ensembl ID		ENSG00000103510	ENSG00000275663
Uniprot IDs		Q9H7Z6	Q99525
PDB IDs		2GIV 2PQ8 2Y0M 3QAH 3TOA 3TOB 4DNC 5H43 5J8C 5J8F 5WCI 6BA2 6BA4 6CT2 6OIN 6OIO 6OIP 6OIQ 6OIR 6OWH 6OWI 6PD8 6PD9 6PDA 6PDB 6PDC 6PDD 6PDE 6PDF 6PDG 7CMR 8W13
Enriched GO Terms of Interacting Partners?		Chromatin Remodeling Chromatin Organization DNA Binding Epigenetic Regulation Of Gene Expression Response To X-ray Regulation Of Gene Expression Positive Regulation Of Transcription By RNA Polymerase II Protein Heterodimerization Activity Structural Constituent Of Chromatin Regulation Of Macromolecule Biosynthetic Process Protein Localization To Chromosome Nucleosome Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA Metabolic Process Chromosome Negative Regulation Of DNA Recombination Negative Regulation Of Cell Population Proliferation Cellular Response To X-ray Positive Regulation Of RNA Biosynthetic Process Regulation Of Macromolecule Metabolic Process Regulation Of Transcription By RNA Polymerase II Positive Regulation Of DNA-templated Transcription Regulation Of RNA Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Cell Cycle Cellular Response To Ionizing Radiation Positive Regulation Of RNA Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Protein-DNA Complex Assembly DNA Repair Complex DNA Strand Resection Involved In Replication Fork Processing Negative Regulation Of Chromosome Organization Replicative Senescence Negative Regulation Of Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Protein Localization To Organelle Negative Regulation Of Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Gene Expression CENP-A Containing Nucleosome Protein Localization To CENP-A Containing Chromatin Regulation Of Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Hematopoietic Or Lymphoid Organ Development Site Of Double-strand Break DNA Damage Checkpoint Signaling Alpha-beta T Cell Activation Regulation Of Cell Population Proliferation Regulation Of Integrin-mediated Signaling Pathway	Histone Acetyltransferase Complex Protein Propionyltransferase Activity Protein-lysine-acetyltransferase Activity Acetyltransferase Activity Histone H3K18 Acetyltransferase Activity Histone Acetyltransferase Activity Histone H4K20me Methyltransferase Activity Histone H4K20 Monomethyltransferase Activity Histone H4 Methyltransferase Activity Histone H4K20 Methyltransferase Activity Histone H3 Acetyltransferase Activity Internal Peptidyl-lysine Acetylation Internal Protein Amino Acid Acetylation Very-low-density Lipoprotein Particle Assembly Histone H4 Acetyltransferase Activity Peptidyl-lysine Acetylation Positive Regulation Of Double-strand Break Repair Via Nonhomologous End Joining Negative Regulation Of Small Molecule Metabolic Process Chromatin Remodeling Condensed Chromosome, Centromeric Region Negative Regulation Of Gluconeogenesis Chromosome Positive Regulation Of Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains S-adenosyl-L-methionine Binding Positive Regulation Of Adaptive Immune Response Plasma Lipoprotein Particle Assembly Protein-lipid Complex Assembly Acyltransferase Activity Positive Regulation Of Isotype Switching Regulation Of Double-strand Break Repair Via Nonhomologous End Joining Chromatin Organization Protein Acetylation DNA-binding Transcription Factor Binding Chromatin Binding Regulation Of Isotype Switching Regulation Of Triglyceride Metabolic Process Regulation Of Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Positive Regulation Of Immunoglobulin Mediated Immune Response Negative Regulation Of Phosphatidylcholine Catabolic Process Positive Regulation Of Gene Expression, Epigenetic Somitogenesis Peptidyl-lysine Propionylation Segmentation Regulation Of Lymphocyte Activation Swimming Histone Lactyltransferase (CoA-dependent) Activity Gluconeogenesis Peptidyl-lysine Butyrylation Peptidyl-lysine Crotonylation Histone H3K122 Acetyltransferase Activity
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