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USHBP1 and PRKAA2
Number of citations of the paper that reports this interaction (PMID
25416956
)
0
Data Source:
BioGRID
(two hybrid)
USHBP1
PRKAA2
Gene Name
Usher syndrome 1C binding protein 1
protein kinase, AMP-activated, alpha 2 catalytic subunit
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Nucleoplasm
Cytosol
Molecular Function
Protein Binding
PDZ Domain Binding
Chromatin Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
AMP-activated Protein Kinase Activity
Protein Serine/threonine/tyrosine Kinase Activity
Protein Binding
ATP Binding
Histone Serine Kinase Activity
Metal Ion Binding
[hydroxymethylglutaryl-CoA Reductase (NADPH)] Kinase Activity
[acetyl-CoA Carboxylase] Kinase Activity
Biological Process
Energy Reserve Metabolic Process
Transcription, DNA-templated
Regulation Of Transcription, DNA-templated
Protein Phosphorylation
Fatty Acid Biosynthetic Process
Cholesterol Biosynthetic Process
Carnitine Shuttle
Autophagy
Response To Stress
Organelle Organization
Mitochondrion Organization
Cell Cycle Arrest
Signal Transduction
Insulin Receptor Signaling Pathway
Lipid Biosynthetic Process
Positive Regulation Of Autophagy
Wnt Signaling Pathway
Cellular Response To Nutrient Levels
Negative Regulation Of TOR Signaling
Histone-serine Phosphorylation
Cellular Response To Glucose Starvation
Regulation Of Fatty Acid Biosynthetic Process
Glucose Homeostasis
Regulation Of Circadian Rhythm
Negative Regulation Of Apoptotic Process
Cellular Lipid Metabolic Process
Small Molecule Metabolic Process
Positive Regulation Of Glycolytic Process
Rhythmic Process
Fatty Acid Homeostasis
Membrane Organization
Regulation Of Energy Homeostasis
Pathways
Organelle biogenesis and maintenance
Integration of energy metabolism
Metabolism of lipids and lipoproteins
Regulation of Rheb GTPase activity by AMPK
IRS-mediated signalling
mTOR signalling
Translocation of GLUT4 to the plasma membrane
Import of palmitoyl-CoA into the mitochondrial matrix
mTOR signalling
IGF1R signaling cascade
IRS-related events triggered by IGF1R
Energy dependent regulation of mTOR by LKB1-AMPK
PKB-mediated events
PI3K Cascade
Signaling by Insulin receptor
Fatty acid, triacylglycerol, and ketone body metabolism
Insulin receptor signalling cascade
Regulation of AMPK activity via LKB1
IRS-related events
Mitochondrial biogenesis
IRS-mediated signalling
Activation of PPARGC1A (PGC-1alpha) by phosphorylation
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
AMPK inhibits chREBP transcriptional activation activity
PKB-mediated events
PI3K Cascade
Drugs
Diseases
GWAS
Lymphocyte counts (
22286170
)
Protein-Protein Interactions
124 interactors:
ABLIM1
AKAP9
ANKRD36BP1
ARFIP2
ARNT2
ATP5O
BCL10
BET1
C10orf10
C1orf109
C1orf216
C6orf165
CCDC116
CCDC120
CCDC121
CCDC146
CCDC148
CCDC22
CCDC24
CCDC33
CCDC87
CCHCR1
CCNK
CENPP
CEP63
CEP68
CHCHD3
CNNM3
COPS4
COPS8
CTNNBIP1
CTTNBP2NL
DTNB
DYDC1
EIF4E2
ERCC1
EXOC7
EXOC8
FAM107A
FAM110A
FAM124B
FANCG
FATE1
FBF1
FTL
GATAD2B
GCC1
GFI1B
GIT2
GMCL1P1
GNG4
GOLGA8EP
GOLGA8F
GPSM1
GPSM3
GTF2H1
HAUS1
HGS
IFT20
IL16
IMP3
ING3
INPP1
INTS4
KANSL1
KIAA0753
KLC3
KLC4
KLHL38
KLHL42
KPNA2
KRT15
KRT19
KRT20
KRT31
KRT38
KRT40
KRT79
LENG1
LINC00526
MAGEB4
MCM7
MCRS1
MED28
MED4
MOS
MRPS23
NCAPH2
NDC80
NDE1
NGFRAP1
NOC4L
PARVG
PMF1
PPP1R7
PPP2R5D
PRC1
PRKAA2
RASAL2
RECK
RIBC2
RNF20
SEC14L4
SERTAD3
SH2D4A
SMARCD1
SMARCE1
STX11
SYNJ2BP
THADA
THOC1
TRIM54
TSG101
TUBGCP4
TXLNA
TXLNB
UBE2W
UBXN11
USH1C
VPS28
ZFYVE26
ZNF483
ZNF765
ZNRF2P1
48 interactors:
ABI2
ACACA
ACACB
AES
AIMP2
APPBP2
C19orf47
CCNB1IP1
EEF2K
EPM2A
FOS
GLI1
HMBOX1
HNF4A
HOMEZ
KCTD1
KIF24
KIFC3
KRT31
KRTAP10-3
L3MBTL3
LEP
MYOZ1
NECAB2
NONO
NOTCH2NL
NRAP
NUTM1
PBXIP1
PFKFB2
PRKAB1
PRKAB2
PRKAG1
RBPMS
RFX6
RPTOR
SNW1
STK11
TCF4
TMOD1
TRIP6
TSC22D4
UBE2I
USHBP1
VPS52
WWP1
ZBTB8A
ZNF397
Entrez ID
83878
5563
HPRD ID
18276
02735
Ensembl ID
ENSG00000130307
ENSG00000162409
Uniprot IDs
G8JLM4
Q8N6Y0
P54646
PDB IDs
2H6D
2LTU
2YZA
3AQV
Enriched GO Terms of Interacting Partners
?
Organelle Organization
Cell Cycle Process
Cell Cycle
Cell Division
Mitotic Cell Cycle
Chromosome Organization
Mitotic Cell Cycle Process
Establishment Of Localization In Cell
Cytoskeleton Organization
Cellular Localization
Microtubule-based Process
Microtubule Cytoskeleton Organization
Chromatin Organization
Chromatin Modification
G2/M Transition Of Mitotic Cell Cycle
Spindle Organization
Regulation Of Metabolic Process
Intracellular Transport Of Virus
Intracellular Transport
Mitotic Nuclear Division
Centrosome Organization
Cellular Process
Cullin Deneddylation
Mitotic Cell Cycle Phase Transition
Cell Cycle Phase Transition
Establishment Of Spindle Orientation
Microtubule Organizing Center Organization
Positive Regulation Of Exosomal Secretion
Regulation Of Exosomal Secretion
Protein Deneddylation
Viral Protein Processing
Establishment Of Cell Polarity
Histone H4 Acetylation
Spindle Localization
Cellular Response To DNA Damage Stimulus
Histone H4-K5 Acetylation
Histone H4-K8 Acetylation
Membrane Organization
Histone H4-K16 Acetylation
Nucleosome Disassembly
ATP-dependent Chromatin Remodeling
Nucleotide-excision Repair, DNA Damage Removal
Microtubule Nucleation
Organelle Fusion
Protein Targeting To Vacuole
Virion Assembly
Energy Reserve Metabolic Process
Biosynthetic Process
Regulation Of Metabolic Process
Transcription, DNA-templated
Cell Cycle Arrest
Negative Regulation Of Transcription, DNA-templated
RNA Biosynthetic Process
Insulin Receptor Signaling Pathway
Regulation Of Gene Expression
Negative Regulation Of Nucleic Acid-templated Transcription
Carnitine Shuttle
Negative Regulation Of RNA Biosynthetic Process
Regulation Of Transcription, DNA-templated
Generation Of Precursor Metabolites And Energy
Cellular Response To Hormone Stimulus
Regulation Of Nucleic Acid-templated Transcription
Response To Insulin
Regulation Of RNA Biosynthetic Process
Cellular Macromolecule Biosynthetic Process
Carnitine Transmembrane Transport
Energy Derivation By Oxidation Of Organic Compounds
Macromolecule Biosynthetic Process
Carnitine Transport
Regulation Of RNA Metabolic Process
Regulation Of Nitrogen Compound Metabolic Process
Negative Regulation Of Gene Expression
Gene Expression
Cellular Response To Insulin Stimulus
Negative Regulation Of Biosynthetic Process
RNA Metabolic Process
Malonyl-CoA Biosynthetic Process
Fatty Acid Biosynthetic Process
Positive Regulation Of Cellular Metabolic Process
Quaternary Ammonium Group Transport
Regulation Of Carbohydrate Metabolic Process
Positive Regulation Of Metabolic Process
Nucleobase-containing Compound Metabolic Process
Regulation Of Lipid Metabolic Process
Response To Peptide Hormone
Heterocycle Metabolic Process
Cellular Response To Peptide Hormone Stimulus
Cellular Aromatic Compound Metabolic Process
Cellular Metabolic Process
Fatty Acid Metabolic Process
Response To Peptide
Cellular Response To Peptide
Regulation Of Insulin Secretion
Glucose Homeostasis
Response To Hormone
Cellular Nitrogen Compound Metabolic Process
Tagcloud
?
amyloidogenesis
apmk
appswe
arc
biogenesis
functionality
igf1
igf2
igfbp2
igfr
impairments
insoluble
insr
intolerant
irs1
irs2
nrf1
oxphos
pampk
pgc
pgc1
plaque
precede
ps1
ps1de9
reinforce
sensors
tfam
thr172
Tagcloud (Difference)
?
amyloidogenesis
apmk
appswe
arc
biogenesis
functionality
igf1
igf2
igfbp2
igfr
impairments
insoluble
insr
intolerant
irs1
irs2
nrf1
oxphos
pampk
pgc
pgc1
plaque
precede
ps1
ps1de9
reinforce
sensors
tfam
thr172
Tagcloud (Intersection)
?