USHBP1 and GNG4

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		USHBP1	GNG4
Gene Name		Usher syndrome 1C binding protein 1	guanine nucleotide binding protein (G protein), gamma 4
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component		Heterotrimeric G-protein Complex Plasma Membrane Extracellular Vesicular Exosome
	Molecular Function	Protein Binding PDZ Domain Binding	Signal Transducer Activity Protein Binding
	Biological Process		Energy Reserve Metabolic Process G-protein Coupled Receptor Signaling Pathway Synaptic Transmission Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Negative Regulation Of Cell Growth Small Molecule Metabolic Process Cellular Response To Glucagon Stimulus
Pathways			Signaling by GPCR Glucagon-like Peptide-1 (GLP1) regulates insulin secretion ADP signalling through P2Y purinoceptor 1 Integration of energy metabolism G alpha (s) signalling events Activation of GABAB receptors Glucagon-type ligand receptors G beta:gamma signalling through PLC beta Signaling by Wnt Metabolic disorders of biological oxidation enzymes G protein gated Potassium channels Gastrin-CREB signalling pathway via PKC and MAPK Thromboxane signalling through TP receptor G alpha (z) signalling events G alpha (i) signalling events Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell ADP signalling through P2Y purinoceptor 12 Glucagon signaling in metabolic regulation Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits Inwardly rectifying K+ channels G-protein beta:gamma signalling Opioid Signalling Activation of Kainate Receptors upon glutamate binding Aquaporin-mediated transport Adrenaline,noradrenaline inhibits insulin secretion G alpha (q) signalling events GPCR downstream signaling Platelet homeostasis Platelet activation, signaling and aggregation Transmission across Chemical Synapses G alpha (q) signalling events Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signal amplification Potassium Channels G beta:gamma signalling through PI3Kgamma G alpha (12/13) signalling events Class B/2 (Secretin family receptors) Prostacyclin signalling through prostacyclin receptor GABA B receptor activation GABA receptor activation Activation of G protein gated Potassium channels Vasopressin regulates renal water homeostasis via Aquaporins Regulation of insulin secretion GPCR ligand binding beta-catenin independent WNT signaling Thrombin signalling through proteinase activated receptors (PARs) Presynaptic function of Kainate receptors Ca2+ pathway G-protein activation
Drugs
Diseases
GWAS			Aging traits ( 17903295)
Protein-Protein Interactions		124 interactors: ABLIM1 AKAP9 ANKRD36BP1 ARFIP2 ARNT2 ATP5O BCL10 BET1 C10orf10 C1orf109 C1orf216 C6orf165 CCDC116 CCDC120 CCDC121 CCDC146 CCDC148 CCDC22 CCDC24 CCDC33 CCDC87 CCHCR1 CCNK CENPP CEP63 CEP68 CHCHD3 CNNM3 COPS4 COPS8 CTNNBIP1 CTTNBP2NL DTNB DYDC1 EIF4E2 ERCC1 EXOC7 EXOC8 FAM107A FAM110A FAM124B FANCG FATE1 FBF1 FTL GATAD2B GCC1 GFI1B GIT2 GMCL1P1 GNG4 GOLGA8EP GOLGA8F GPSM1 GPSM3 GTF2H1 HAUS1 HGS IFT20 IL16 IMP3 ING3 INPP1 INTS4 KANSL1 KIAA0753 KLC3 KLC4 KLHL38 KLHL42 KPNA2 KRT15 KRT19 KRT20 KRT31 KRT38 KRT40 KRT79 LENG1 LINC00526 MAGEB4 MCM7 MCRS1 MED28 MED4 MOS MRPS23 NCAPH2 NDC80 NDE1 NGFRAP1 NOC4L PARVG PMF1 PPP1R7 PPP2R5D PRC1 PRKAA2 RASAL2 RECK RIBC2 RNF20 SEC14L4 SERTAD3 SH2D4A SMARCD1 SMARCE1 STX11 SYNJ2BP THADA THOC1 TRIM54 TSG101 TUBGCP4 TXLNA TXLNB UBE2W UBXN11 USH1C VPS28 ZFYVE26 ZNF483 ZNF765 ZNRF2P1	8 interactors: GNB1 GNB2 GNB3 GNB4 GNB5 RAF1 TFIP11 USHBP1
Entrez ID		83878	2786
HPRD ID		18276	11978
Ensembl ID		ENSG00000130307	ENSG00000168243
Uniprot IDs		G8JLM4 Q8N6Y0	B1APZ0 P50150
PDB IDs
Enriched GO Terms of Interacting Partners?		Organelle Organization Cell Cycle Process Cell Cycle Cell Division Mitotic Cell Cycle Chromosome Organization Mitotic Cell Cycle Process Establishment Of Localization In Cell Cytoskeleton Organization Cellular Localization Microtubule-based Process Microtubule Cytoskeleton Organization Chromatin Organization Chromatin Modification G2/M Transition Of Mitotic Cell Cycle Spindle Organization Regulation Of Metabolic Process Intracellular Transport Of Virus Intracellular Transport Mitotic Nuclear Division Centrosome Organization Cellular Process Cullin Deneddylation Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Establishment Of Spindle Orientation Microtubule Organizing Center Organization Positive Regulation Of Exosomal Secretion Regulation Of Exosomal Secretion Protein Deneddylation Viral Protein Processing Establishment Of Cell Polarity Histone H4 Acetylation Spindle Localization Cellular Response To DNA Damage Stimulus Histone H4-K5 Acetylation Histone H4-K8 Acetylation Membrane Organization Histone H4-K16 Acetylation Nucleosome Disassembly ATP-dependent Chromatin Remodeling Nucleotide-excision Repair, DNA Damage Removal Microtubule Nucleation Organelle Fusion Protein Targeting To Vacuole Virion Assembly	Cellular Response To Glucagon Stimulus Response To Glucagon Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide Energy Reserve Metabolic Process Response To Peptide Hormone Cellular Response To Organonitrogen Compound Response To Peptide Cellular Response To Hormone Stimulus Energy Derivation By Oxidation Of Organic Compounds Response To Organonitrogen Compound Response To Hormone Generation Of Precursor Metabolites And Energy Synaptic Transmission Regulation Of Rhodopsin Mediated Signaling Pathway Rhodopsin Mediated Signaling Pathway Cellular Response To Organic Substance Cell-cell Signaling G-protein Coupled Receptor Signaling Pathway Phototransduction, Visible Light Response To Organic Substance Detection Of Visible Light Death-inducing Signaling Complex Assembly Spliceosomal Complex Disassembly Cellular Response To Light Stimulus Phototransduction Detection Of Light Stimulus Oxidation-reduction Process Cell Surface Receptor Signaling Pathway Signal Transduction Cellular Response To Radiation Signaling Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Detection Of Abiotic Stimulus Cell Communication Platelet Activation Negative Regulation Of Voltage-gated Calcium Channel Activity Ras Protein Signal Transduction Cardiac Muscle Cell Apoptotic Process Muscle Cell Apoptotic Process Cellular Response To Stimulus Small Molecule Metabolic Process Response To Abiotic Stimulus Response To Hypoxia Cellular Response To Prostaglandin E Stimulus Response To Light Stimulus G-protein Coupled Acetylcholine Receptor Signaling Pathway Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Negative Regulation Of Calcium Ion Transmembrane Transporter Activity Cellular Response To Prostaglandin Stimulus
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