USHBP1 and PPP2R5D

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		USHBP1	PPP2R5D
Gene Name		Usher syndrome 1C binding protein 1	protein phosphatase 2, regulatory subunit B, delta
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component		Protein Phosphatase Type 2A Complex Nucleus Nucleoplasm Cytosol
	Molecular Function	Protein Binding PDZ Domain Binding	Protein Serine/threonine Phosphatase Activity Protein Binding Protein Phosphatase Type 2A Regulator Activity
	Biological Process		Toll-like Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Carbohydrate Metabolic Process Glucose Metabolic Process Glycolytic Process Energy Reserve Metabolic Process Nervous System Development Pathogenesis Dephosphorylation Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Toll-like Receptor 10 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Small Molecule Metabolic Process Innate Immune Response Neurotrophin TRK Receptor Signaling Pathway Regulation Of Catalytic Activity Stress-activated MAPK Cascade
Pathways			Signaling by GPCR Integration of energy metabolism misspliced GSK3beta mutants stabilize beta-catenin T41 mutants of beta-catenin aren't phosphorylated ERKs are inactivated truncated APC mutants destabilize the destruction complex TCF7L2 mutants don't bind CTBP Glycolysis Signaling by Wnt Glucose metabolism Toll Like Receptor TLR1:TLR2 Cascade Degradation of beta-catenin by the destruction complex Toll Like Receptor 5 (TLR5) Cascade RNF mutants show enhanced WNT signaling and proliferation Myoclonic epilepsy of Lafora S33 mutants of beta-catenin aren't phosphorylated AXIN mutants destabilize the destruction complex, activating WNT signaling Glycogen storage diseases MyD88 dependent cascade initiated on endosome Toll Like Receptor 9 (TLR9) Cascade Beta-catenin phosphorylation cascade ERK/MAPK targets truncations of AMER1 destabilize the destruction complex misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling TRIF-mediated TLR3/TLR4 signaling Opioid Signalling phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex AXIN missense mutants destabilize the destruction complex S45 mutants of beta-catenin aren't phosphorylated Toll Like Receptor 2 (TLR2) Cascade Platelet homeostasis deletions in the AMER1 gene destabilize the destruction complex Platelet sensitization by LDL AMER1 mutants destabilize the destruction complex Resolution of Sister Chromatid Cohesion Toll Like Receptor 3 (TLR3) Cascade Toll Like Receptor 4 (TLR4) Cascade Metabolism of carbohydrates Mitotic Metaphase and Anaphase Adaptive Immune System PP2A-mediated dephosphorylation of key metabolic factors Mitotic Prometaphase Costimulation by the CD28 family Separation of Sister Chromatids Toll Like Receptor 7/8 (TLR7/8) Cascade APC truncation mutants have impaired AXIN binding Mitotic Anaphase Toll Like Receptor TLR6:TLR2 Cascade M Phase APC truncation mutants are not K63 polyubiquitinated disassembly of the destruction complex and recruitment of AXIN to the membrane Activated TLR4 signalling S37 mutants of beta-catenin aren't phosphorylated MyD88 cascade initiated on plasma membrane DARPP-32 events XAV939 inhibits tankyrase, stabilizing AXIN TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation MyD88:Mal cascade initiated on plasma membrane Innate Immune System ERKs are inactivated Signalling by NGF MAP kinase activation in TLR cascade CTLA4 inhibitory signaling NGF signalling via TRKA from the plasma membrane MyD88-independent cascade Cell Cycle, Mitotic Toll-Like Receptors Cascades Toll Like Receptor 10 (TLR10) Cascade TCF dependent signaling in response to WNT ERK/MAPK targets deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling MAPK targets/ Nuclear events mediated by MAP kinases Signaling by WNT in cancer Nuclear Events (kinase and transcription factor activation)
Drugs
Diseases
GWAS
Protein-Protein Interactions		124 interactors: ABLIM1 AKAP9 ANKRD36BP1 ARFIP2 ARNT2 ATP5O BCL10 BET1 C10orf10 C1orf109 C1orf216 C6orf165 CCDC116 CCDC120 CCDC121 CCDC146 CCDC148 CCDC22 CCDC24 CCDC33 CCDC87 CCHCR1 CCNK CENPP CEP63 CEP68 CHCHD3 CNNM3 COPS4 COPS8 CTNNBIP1 CTTNBP2NL DTNB DYDC1 EIF4E2 ERCC1 EXOC7 EXOC8 FAM107A FAM110A FAM124B FANCG FATE1 FBF1 FTL GATAD2B GCC1 GFI1B GIT2 GMCL1P1 GNG4 GOLGA8EP GOLGA8F GPSM1 GPSM3 GTF2H1 HAUS1 HGS IFT20 IL16 IMP3 ING3 INPP1 INTS4 KANSL1 KIAA0753 KLC3 KLC4 KLHL38 KLHL42 KPNA2 KRT15 KRT19 KRT20 KRT31 KRT38 KRT40 KRT79 LENG1 LINC00526 MAGEB4 MCM7 MCRS1 MED28 MED4 MOS MRPS23 NCAPH2 NDC80 NDE1 NGFRAP1 NOC4L PARVG PMF1 PPP1R7 PPP2R5D PRC1 PRKAA2 RASAL2 RECK RIBC2 RNF20 SEC14L4 SERTAD3 SH2D4A SMARCD1 SMARCE1 STX11 SYNJ2BP THADA THOC1 TRIM54 TSG101 TUBGCP4 TXLNA TXLNB UBE2W UBXN11 USH1C VPS28 ZFYVE26 ZNF483 ZNF765 ZNRF2P1	9 interactors: CHEK2 FSD2 HAND1 HAND2 PPFIA1 PPP2R1B PPP4C SGOL1 USHBP1
Entrez ID		83878	5528
HPRD ID		18276	09039
Ensembl ID		ENSG00000130307	ENSG00000112640
Uniprot IDs		G8JLM4 Q8N6Y0	Q14738
PDB IDs
Enriched GO Terms of Interacting Partners?		Organelle Organization Cell Cycle Process Cell Cycle Cell Division Mitotic Cell Cycle Chromosome Organization Mitotic Cell Cycle Process Establishment Of Localization In Cell Cytoskeleton Organization Cellular Localization Microtubule-based Process Microtubule Cytoskeleton Organization Chromatin Organization Chromatin Modification G2/M Transition Of Mitotic Cell Cycle Spindle Organization Regulation Of Metabolic Process Intracellular Transport Of Virus Intracellular Transport Mitotic Nuclear Division Centrosome Organization Cellular Process Cullin Deneddylation Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Establishment Of Spindle Orientation Microtubule Organizing Center Organization Positive Regulation Of Exosomal Secretion Regulation Of Exosomal Secretion Protein Deneddylation Viral Protein Processing Establishment Of Cell Polarity Histone H4 Acetylation Spindle Localization Cellular Response To DNA Damage Stimulus Histone H4-K5 Acetylation Histone H4-K8 Acetylation Membrane Organization Histone H4-K16 Acetylation Nucleosome Disassembly ATP-dependent Chromatin Remodeling Nucleotide-excision Repair, DNA Damage Removal Microtubule Nucleation Organelle Fusion Protein Targeting To Vacuole Virion Assembly	Cardiac Right Ventricle Formation Cardiac Ventricle Formation Cardiac Chamber Formation Cartilage Morphogenesis Cardiac Right Ventricle Morphogenesis Apoptotic Process Involved In Morphogenesis Regulation Of Transcription Regulatory Region DNA Binding Apoptotic Process Involved In Development Developmental Programmed Cell Death Negative Regulation Of DNA Binding Heart Looping Determination Of Heart Left/right Asymmetry Embryonic Heart Tube Morphogenesis Cardiac Ventricle Morphogenesis Embryonic Heart Tube Development Regulation Of DNA Binding Embryonic Heart Tube Formation Signal Transduction Involved In Intra-S DNA Damage Checkpoint Negative Regulation Of RNA Polymerase II Regulatory Region Sequence-specific DNA Binding Positive Regulation Of Semaphorin-plexin Signaling Pathway Involved In Outflow Tract Morphogenesis Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Norepinephrine Biosynthetic Process Negative Regulation Of Binding Odontogenesis Of Dentin-containing Tooth Cardiac Ventricle Development Determination Of Left/right Symmetry Determination Of Bilateral Symmetry Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Cardiac Left Ventricle Formation Cell Proliferation Involved In Outflow Tract Morphogenesis Visceral Serous Pericardium Development Odontogenesis Cardiac Chamber Development Apoptotic Process Involved In Heart Morphogenesis Cardiac Neural Crest Cell Migration Involved In Outflow Tract Morphogenesis Cartilage Development Mesenchyme Development Centriole-centriole Cohesion Norepinephrine Biosynthetic Process Heart Morphogenesis Cardiac Neural Crest Cell Development Involved In Outflow Tract Morphogenesis Coronary Artery Morphogenesis Noradrenergic Neuron Differentiation Apoptotic Process Connective Tissue Development Programmed Cell Death Regulation Of Binding Positive Regulation Of Transcription Regulatory Region DNA Binding Cell Death Death Negative Regulation Of Stress Fiber Assembly
Tagcloud ?			altering cacnb4 concomitantly couples dephosphorylation electrical epilepsy excitability gated gk guanylate hp1gamma hydroxylase juvenile modules myoclonic platform pp2a prevents r482x recruiting repressor sh3 signalling th tralpha vgcc voltage
Tagcloud (Difference) ?			altering cacnb4 concomitantly couples dephosphorylation electrical epilepsy excitability gated gk guanylate hp1gamma hydroxylase juvenile modules myoclonic platform pp2a prevents r482x recruiting repressor sh3 signalling th tralpha vgcc voltage
Tagcloud (Intersection) ?