L3MBTL2 and RNF2

Number of citations of the paper that reports this interaction (PMID 22325352)
61

Data Source:
BioGRID (pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology)

		L3MBTL2	RNF2
Gene Name		l(3)mbt-like 2 (Drosophila)	ring finger protein 2
Image
Gene Ontology Annotations	Cellular Component	Nucleus	Ubiquitin Ligase Complex Euchromatin Sex Chromatin Nucleus Nucleoplasm Nuclear Body PcG Protein Complex PRC1 Complex MLL1 Complex
	Molecular Function	Protein Binding Zinc Ion Binding Methylated Histone Binding Histone Binding	Chromatin Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Ligase Activity RING-like Zinc Finger Domain Binding
	Biological Process	Transcription, DNA-templated Regulation Of Transcription, DNA-templated Chromatin Modification	Negative Regulation Of Transcription From RNA Polymerase II Promoter Mitotic Cell Cycle Gastrulation With Mouth Forming Second Transcription, DNA-templated Anterior/posterior Axis Specification Histone H2A Monoubiquitination Histone H2A-K119 Monoubiquitination
Pathways			Oxidative Stress Induced Senescence Cellular Senescence
Drugs
Diseases
GWAS			Obesity-related traits ( 23251661)
Protein-Protein Interactions		14 interactors: AES CBX3 HIST1H3A HIST1H4A MEAF6 MPP3 PAICS PHF10 PIAS1 RNF2 STAC3 STAM2 TBC1D9B TRIM42	54 interactors: ABCB1 AMBRA1 BMI1 CASP3 CASP9 CBX4 CBX6 CBX7 CBX8 HIST1H2AB HIST2H2AA3 HIST2H2AC HIST3H3 KAT8 KMT2A L3MBTL2 MBD1 OTUD6A PCGF1 PCGF2 PCGF3 PCGF5 PCGF6 PGP PHB2 PHC1 PSMC4 RING1 RRM1 RYBP SMURF2 SSX2 TARDBP TFCP2 UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2H UBE2J1 UBE2K UBE2L3 UBE2U UBE2V1 UBE2V2 UBE2W UBE3A USP11 USP19 USP7 WASH1
Entrez ID		83746	6045
HPRD ID		13954	07028
Ensembl ID		ENSG00000100395	ENSG00000121481
Uniprot IDs		Q969R5	B3KRH1 Q99496
PDB IDs		2W0T 3CEY 3F70	2H0D 3GS2 3H8H 3IXS 3RPG
Enriched GO Terms of Interacting Partners?		DNA Replication-dependent Nucleosome Assembly Nucleobase-containing Compound Metabolic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process DNA Methylation On Cytosine Chromatin Organization Cellular Nitrogen Compound Metabolic Process Chromatin Silencing At RDNA Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Nitrogen Compound Metabolic Process Protein-DNA Complex Assembly Gene Expression Chromosome Organization Chromatin Silencing Chromatin Modification Negative Regulation Of Cellular Metabolic Process DNA Methylation Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Transcription, DNA-templated Negative Regulation Of Gene Expression, Epigenetic Regulation Of RNA Metabolic Process RNA Biosynthetic Process DNA Modification Histone Modification Histone H2A-K119 Monoubiquitination Gene Silencing Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Histone H4-K20 Demethylation Regulation Of Cellular Process Nucleosome Assembly Positive Regulation Of Anoikis Chromatin Assembly Negative Regulation Of Megakaryocyte Differentiation Positive Regulation Of Smooth Muscle Cell Differentiation Nucleosome Organization Chromatin Assembly Or Disassembly 'de Novo' IMP Biosynthetic Process Histone H3-K14 Acetylation RNA Metabolic Process Cellular Macromolecular Complex Assembly Chromatin Remodeling DNA Packaging Negative Regulation Of Hematopoietic Progenitor Cell Differentiation See more	Protein Modification By Small Protein Conjugation Protein Ubiquitination Protein Polyubiquitination Protein K48-linked Ubiquitination Cellular Protein Modification Process Histone Ubiquitination Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Protein K11-linked Ubiquitination Cellular Protein Catabolic Process Chromatin Modification Cellular Macromolecule Catabolic Process Protein Catabolic Process Cellular Metabolic Process Chromatin Organization Cellular Protein Metabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Transcription, DNA-templated Chromosome Organization Histone Modification RNA Biosynthetic Process Protein Metabolic Process Nucleobase-containing Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Proteolysis Protein Monoubiquitination Negative Regulation Of RNA Biosynthetic Process Nitrogen Compound Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Catabolic Process Cellular Macromolecule Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Protein K63-linked Ubiquitination Macromolecule Biosynthetic Process Metabolic Process Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of Gene Expression Regulation Of Nucleic Acid-templated Transcription Gene Expression Regulation Of Metabolic Process Regulation Of RNA Biosynthetic Process Negative Regulation Of Biosynthetic Process RNA Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Gene Expression See more
Tagcloud ?		700r analyse balancing compaction competent defective dub essentially facilitates flag h2aub1 hek293 integral k675 lethal occupancy occupied polycomb prc1 repressed repressive ring2 seq stably sumo2 sumoylation tagged tails ubiquitinating	aldrich ambra1 arp2 associates autophagy becn1 cul4a ddb1 e3 elusive endosomal impairs impede interactor k48 k63 ligase linkage pik3c3 potentiates scar sorting starvation suppresses ubiquitinate ubiquitination wash wasp wiskott
Tagcloud (Difference) ?		700r analyse balancing compaction competent defective dub essentially facilitates flag h2aub1 hek293 integral k675 lethal occupancy occupied polycomb prc1 repressed repressive ring2 seq stably sumo2 sumoylation tagged tails ubiquitinating	aldrich ambra1 arp2 associates autophagy becn1 cul4a ddb1 e3 elusive endosomal impairs impede interactor k48 k63 ligase linkage pik3c3 potentiates scar sorting starvation suppresses ubiquitinate ubiquitination wash wasp wiskott
Tagcloud (Intersection) ?