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L3MBTL2 and HIST1H4A
Number of citations of the paper that reports this interaction (PMID
20385135
)
3
Data Source:
BioGRID
(unspecified method, unspecified method)
L3MBTL2
HIST1H4A
Gene Name
l(3)mbt-like 2 (Drosophila)
histone cluster 1, H4a
Image
Gene Ontology Annotations
Cellular Component
Nucleus
Nuclear Chromosome
Nucleosome
Extracellular Region
Nucleus
Nucleoplasm
Membrane
Protein Complex
Extracellular Vesicular Exosome
Molecular Function
Protein Binding
Zinc Ion Binding
Methylated Histone Binding
Histone Binding
DNA Binding
Protein Binding
Histone Demethylase Activity (H4-K20 Specific)
Poly(A) RNA Binding
Protein Heterodimerization Activity
Biological Process
Transcription, DNA-templated
Regulation Of Transcription, DNA-templated
Chromatin Modification
Chromatin Silencing At RDNA
Mitotic Cell Cycle
Telomere Maintenance
Chromatin Organization
Nucleosome Assembly
DNA Replication-dependent Nucleosome Assembly
DNA Replication-independent Nucleosome Assembly
Gene Expression
DNA Methylation On Cytosine
CENP-A Containing Nucleosome Assembly
Histone H4-K20 Demethylation
Regulation Of Gene Expression, Epigenetic
Negative Regulation Of Megakaryocyte Differentiation
Negative Regulation Of Gene Expression, Epigenetic
Pathways
RNA Polymerase I Chain Elongation
RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription
Mitotic Prophase
PKMTs methylate histone lysines
Regulatory RNA pathways
RNA Polymerase I Promoter Clearance
Deposition of new CENPA-containing nucleosomes at the centromere
HDMs demethylate histones
Cellular Senescence
Signaling by Wnt
HATs acetylate histones
M Phase
Amyloids
NoRC negatively regulates rRNA expression
Packaging Of Telomere Ends
Telomere Maintenance
Nucleosome assembly
RNF mutants show enhanced WNT signaling and proliferation
XAV939 inhibits tankyrase, stabilizing AXIN
DNA methylation
Transcriptional regulation by small RNAs
Meiotic recombination
DNA Damage/Telomere Stress Induced Senescence
Chromosome Maintenance
HDACs deacetylate histones
Chromatin organization
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
RNA Polymerase I Transcription
formation of the beta-catenin:TCF transactivating complex
Meiotic synapsis
Epigenetic regulation of gene expression
Senescence-Associated Secretory Phenotype (SASP)
Negative epigenetic regulation of rRNA expression
PRC2 methylates histones and DNA
Cell Cycle, Mitotic
RMTs methylate histone arginines
Chromatin modifying enzymes
Oxidative Stress Induced Senescence
TCF dependent signaling in response to WNT
RNA Polymerase I Promoter Opening
SIRT1 negatively regulates rRNA Expression
Signaling by WNT in cancer
Condensation of Prophase Chromosomes
Drugs
Diseases
GWAS
HIV-1 viral setpoint (
22174851
)
Protein-Protein Interactions
14 interactors:
AES
CBX3
HIST1H3A
HIST1H4A
MEAF6
MPP3
PAICS
PHF10
PIAS1
RNF2
STAC3
STAM2
TBC1D9B
TRIM42
73 interactors:
ANP32A
BAZ1B
BAZ2A
BLOC1S1
BRD2
CALCOCO1
CBX3
CDK1
CDK2
COPS2
CREBBP
CTDP1
DYRK1A
EID1
ELP3
EP300
ERCC6
GATAD2A
GATAD2B
HAT1
HDAC1
HDAC2
HDAC3
HDAC8
HIRIP3
HIST1H3A
HIST2H2AC
HIST2H2BE
HJURP
KAT2A
KAT2B
KAT5
KAT6A
KAT7
KAT8
KDM4A
KMT2A
L3MBTL2
MSL2
MSL3
NASP
NCOR1
NCOR2
NPM1
NR1H4
PAK1
PARP1
PARP10
PBRM1
PELP1
PHF20
PHF8
PRMT1
PRMT5
PRMT7
PRMT8
PTMA
RCC1
SETD7
SIRT7
SSRP1
SUV420H1
SUV420H2
TAF1
TAF1A
TAF1B
TBL1X
THAP7
TP53BP1
UBC
UBE2I
UCHL5
YY1
Entrez ID
83746
8359
HPRD ID
13954
04157
Ensembl ID
ENSG00000100395
ENSG00000196176
Uniprot IDs
Q969R5
B2R4R0
P62805
PDB IDs
2W0T
3CEY
3F70
2BQZ
2CV5
2KWN
2KWO
2LVM
2QQS
2RNY
2RS9
3A6N
3AFA
3AN2
3AV1
3AV2
3AYW
3AZE
3AZF
3AZG
3AZH
3AZI
3AZJ
3AZK
3AZL
3AZM
3AZN
3CFS
3CFV
3F9W
3F9X
3F9Y
3F9Z
3NQJ
3NQU
3O36
3QZS
3QZT
3QZV
3R45
3UVW
3UVX
3UVY
3UW9
3W96
3W97
3W98
3W99
4GQB
4H9N
4H9O
4H9P
4H9Q
4H9R
4H9S
4HGA
Enriched GO Terms of Interacting Partners
?
DNA Replication-dependent Nucleosome Assembly
Nucleobase-containing Compound Metabolic Process
Negative Regulation Of Transcription, DNA-templated
Negative Regulation Of Nucleic Acid-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
DNA Methylation On Cytosine
Chromatin Organization
Cellular Nitrogen Compound Metabolic Process
Chromatin Silencing At RDNA
Negative Regulation Of Gene Expression
Negative Regulation Of Biosynthetic Process
Nitrogen Compound Metabolic Process
Protein-DNA Complex Assembly
Gene Expression
Chromosome Organization
Chromatin Silencing
Chromatin Modification
Negative Regulation Of Cellular Metabolic Process
DNA Methylation
Regulation Of Transcription, DNA-templated
Regulation Of Nucleic Acid-templated Transcription
Regulation Of RNA Biosynthetic Process
Transcription, DNA-templated
Negative Regulation Of Gene Expression, Epigenetic
Regulation Of RNA Metabolic Process
RNA Biosynthetic Process
DNA Modification
Histone Modification
Histone H2A-K119 Monoubiquitination
Gene Silencing
Regulation Of Gene Expression
Regulation Of Nitrogen Compound Metabolic Process
Histone H4-K20 Demethylation
Regulation Of Cellular Process
Nucleosome Assembly
Positive Regulation Of Anoikis
Chromatin Assembly
Negative Regulation Of Megakaryocyte Differentiation
Positive Regulation Of Smooth Muscle Cell Differentiation
Nucleosome Organization
Chromatin Assembly Or Disassembly
'de Novo' IMP Biosynthetic Process
Histone H3-K14 Acetylation
RNA Metabolic Process
Cellular Macromolecular Complex Assembly
Chromatin Remodeling
DNA Packaging
Negative Regulation Of Hematopoietic Progenitor Cell Differentiation
Chromatin Organization
Chromatin Modification
Chromosome Organization
Histone Modification
Transcription, DNA-templated
RNA Biosynthetic Process
Regulation Of RNA Metabolic Process
Regulation Of RNA Biosynthetic Process
Cellular Macromolecule Biosynthetic Process
Regulation Of Transcription, DNA-templated
Regulation Of Nucleic Acid-templated Transcription
Macromolecule Biosynthetic Process
Regulation Of Gene Expression
Regulation Of Nitrogen Compound Metabolic Process
Organelle Organization
RNA Metabolic Process
Gene Expression
Nucleobase-containing Compound Metabolic Process
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Cellular Nitrogen Compound Metabolic Process
Biosynthetic Process
Nitrogen Compound Metabolic Process
Peptidyl-lysine Modification
Regulation Of Metabolic Process
Peptidyl-lysine Acetylation
Peptidyl-amino Acid Modification
Protein Acetylation
Negative Regulation Of Transcription, DNA-templated
Negative Regulation Of Nucleic Acid-templated Transcription
Histone Acetylation
Negative Regulation Of RNA Biosynthetic Process
Internal Peptidyl-lysine Acetylation
Cellular Protein Modification Process
Internal Protein Amino Acid Acetylation
Negative Regulation Of Gene Expression
Cellular Metabolic Process
Negative Regulation Of Biosynthetic Process
Negative Regulation Of Cellular Metabolic Process
Positive Regulation Of Gene Expression
Histone H4 Acetylation
Cellular Protein Metabolic Process
Positive Regulation Of Macromolecule Biosynthetic Process
Regulation Of Transcription From RNA Polymerase II Promoter
Positive Regulation Of Cellular Biosynthetic Process
Chromatin Remodeling
Chromatin Assembly Or Disassembly
Regulation Of Cellular Process
Positive Regulation Of Transcription, DNA-templated
Transcription From RNA Polymerase II Promoter
Tagcloud
?
700r
analyse
balancing
compaction
competent
defective
dub
essentially
facilitates
flag
h2aub1
hek293
integral
k675
lethal
occupancy
occupied
polycomb
prc1
repressed
repressive
ring2
seq
stably
sumo2
sumoylation
tagged
tails
ubiquitinating
Tagcloud (Difference)
?
700r
analyse
balancing
compaction
competent
defective
dub
essentially
facilitates
flag
h2aub1
hek293
integral
k675
lethal
occupancy
occupied
polycomb
prc1
repressed
repressive
ring2
seq
stably
sumo2
sumoylation
tagged
tails
ubiquitinating
Tagcloud (Intersection)
?