EPPK1 and UCHL5

Number of citations of the paper that reports this interaction (PubMedID 21800051)
0

Data Source:
BioGRID (pull down)

		EPPK1	UCHL5
Description		epiplakin 1	ubiquitin C-terminal hydrolase L5
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytoskeleton Intermediate Filament Plasma Membrane Cell-cell Junction Bicellular Tight Junction Membrane Basolateral Plasma Membrane Apicolateral Plasma Membrane Cell Junction Hemidesmosome Cell Projection Keratin Filament Intermediate Filament Cytoskeleton Anchoring Junction Cell Periphery Perinucleolar Compartment	Proteasome Complex Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Ino80 Complex
	Molecular Function	RNA Binding Structural Molecule Activity Intermediate Filament Binding Keratin Filament Binding	RNA Binding Cysteine-type Deubiquitinase Activity Endopeptidase Inhibitor Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity Proteasome Binding
	Biological Process	Negative Regulation Of Keratinocyte Proliferation Negative Regulation Of Cell Migration Wound Healing Intermediate Filament Cytoskeleton Organization Intermediate Filament Organization Intermediate Filament Bundle Assembly Negative Regulation Of Epithelial Cell Proliferation Negative Regulation Of Keratinocyte Migration Negative Regulation Of Wound Healing Regulation Of Epithelium Regeneration	Telomere Maintenance Regulation Of DNA Replication DNA Repair Regulation Of DNA Repair DNA Recombination Chromatin Remodeling Proteolysis Ubiquitin-dependent Protein Catabolic Process DNA Damage Response Protein Deubiquitination Lateral Ventricle Development Midbrain Development Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Chromosome Organization Positive Regulation Of DNA Repair Positive Regulation Of Smoothened Signaling Pathway Positive Regulation Of DNA-templated Transcription Regulation Of Embryonic Development Forebrain Morphogenesis Regulation Of Cell Cycle Regulation Of DNA Strand Elongation Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Telomere Maintenance In Response To DNA Damage
Pathways			Downregulation of TGF-beta receptor signaling UCH proteinases UCH proteinases
Drugs
Diseases
GWAS		Knee osteoarthritis ( 28916551) Multiple sclerosis ( 31604244)	Cannabis dependence ( 21668797)
Interacting Genes		4 interacting genes: EGFR RNF10 SUMO2 UCHL5	104 interacting genes: ACTN4 ADRM1 ANP32B ANP32E ANXA1 ANXA4 ANXA7 ANXA8 ANXA8L1 APP ARG1 ASPRV1 AXIN1 CALM1 CAP1 CAPZA1 CASP14 CDSN CFL1 CSTA DSC1 DSC3 DSP DUSP14 E2F1 E2F2 E2F3 EEF1G EEF2 EIF4A1 EPPK1 FLG GSTM3 H4C1 H4C11 H4C12 H4C13 H4C14 H4C15 H4C16 H4C2 H4C3 H4C4 H4C5 H4C6 H4C8 H4C9 HAUS7 HBA1 HBA2 HBB HSPB1 IDE IGHG1 IVL KDM1A KRT12 KRT19 KRT26 KRT28 KRT73 KRT78 KRT80 LMNA MAP3K1 NACA OGT PJA1 PKM PKP1 PLA2G2A PNP POF1B PRDX6 PSMD8 RAB7A RBCK1 RFFL RNF4 S100A14 S100A16 S100A7 SERPINB12 SERPINB3 SERPINB5 SET SMAD2 SMAD3 SMAD7 TCF7 TGM3 TPI1 TRIM27 TRIM46 TRIM54 TRIM55 TRIM63 TUBA4A TXN TXN2 UBC USP28 YWHAZ ZBED1
Entrez ID		83481	51377
HPRD ID		06500	10293
Ensembl ID		ENSG00000261150	ENSG00000116750
Uniprot IDs		P58107	Q5LJA5 Q9Y5K5
PDB IDs			3A7S 3IHR 3RII 3RIS 3TB3 4UEL 4UEM 4UF5 4UF6 4WLP
Enriched GO Terms of Interacting Partners?		Regulation Of Peptidyl-serine Phosphorylation Positive Regulation Of Peptidyl-serine Phosphorylation Regulation Of Protein Catabolic Process Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of DNA Repair Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Embryonic Organ Development Positive Regulation Of Protein Kinase C Signaling Positive Regulation Of DNA-templated Transcription Regulation Of DNA Replication Epidermal Growth Factor Receptor Activity Negative Regulation Of Protein Catabolic Process Shc-EGFR Complex Positive Regulation Of RNA Metabolic Process Regulation Of Protein Metabolic Process Multivesicular Body, Internal Vesicle Lumen Protein Modification Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Hepatocyte Apoptotic Process Positive Regulation Of Substrate-dependent Cell Migration, Cell Attachment To Substrate Positive Regulation Of Protein Metabolic Process Epithelial Cell Proliferation Epidermal Growth Factor Binding Cell Morphogenesis Post-translational Protein Modification Regulation Of Ubiquitin-dependent Protein Catabolic Process Primitive Hemopoiesis Regulation Of Protein Kinase C Signaling Regulation Of Proteasomal Protein Catabolic Process Regulation Of Cell Differentiation Involved In Embryonic Placenta Development Endocardium Development Postsynapse To Nucleus Signaling Pathway Extrinsic Component Of Postsynaptic Density Membrane Negative Regulation Of Developmental Process Regulation Of DNA Repair Positive Regulation Of Protein Phosphorylation Regulation Of Developmental Process Regulation Of Primary Metabolic Process Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Phosphorylation Positive Regulation Of Macromolecule Biosynthetic Process ERBB2-EGFR Signaling Pathway Negative Regulation Of Schwann Cell Proliferation Positive Regulation Of Biosynthetic Process Positive Regulation Of DNA Metabolic Process Neural Tube Formation Ribosome-associated Ubiquitin-dependent Protein Catabolic Process Forebrain Morphogenesis	CENP-A Containing Nucleosome Protein Localization To CENP-A Containing Chromatin Negative Regulation Of Megakaryocyte Differentiation Extracellular Exosome Regulation Of Megakaryocyte Differentiation Protein Localization To Chromosome, Centromeric Region Protein Localization To Chromatin Nucleosome Assembly Cornified Envelope Nucleosome Organization Structural Constituent Of Chromatin Negative Regulation Of Myeloid Cell Differentiation Protein Localization To Chromosome Nucleosome Protein-DNA Complex Assembly Telomere Organization Protein-containing Complex Chromosome, Telomeric Region Negative Regulation Of Cell Differentiation Intermediate Filament Organization Chromatin Remodeling Regulation Of Myeloid Cell Differentiation Structural Constituent Of Skin Epidermis Regulation Of Hemopoiesis Chromatin Organization Extracellular Region Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Epithelial Cell Differentiation Negative Regulation Of Developmental Process Desmosome Regulation Of Cell Development Organelle Organization Peptide Cross-linking Regulation Of Cell Differentiation Protein Heterodimerization Activity Intermediate Filament Keratin Filament Keratinocyte Differentiation Supramolecular Fiber Organization Protein Localization To Organelle RNA Binding Chromosome Organization Regulation Of Developmental Process Regulation Of Multicellular Organismal Development Regulation Of Multicellular Organismal Process Nucleus Regulation Of Immune System Process Epidermal Cell Differentiation Haptoglobin Binding
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