EPPK1

Description		epiplakin 1
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytoskeleton Intermediate Filament Plasma Membrane Cell-cell Junction Bicellular Tight Junction Membrane Basolateral Plasma Membrane Apicolateral Plasma Membrane Cell Junction Hemidesmosome Cell Projection Keratin Filament Intermediate Filament Cytoskeleton Anchoring Junction Cell Periphery Perinucleolar Compartment
	Molecular Function	RNA Binding Structural Molecule Activity Intermediate Filament Binding Keratin Filament Binding
	Biological Process	Negative Regulation Of Keratinocyte Proliferation Negative Regulation Of Cell Migration Wound Healing Intermediate Filament Cytoskeleton Organization Intermediate Filament Organization Intermediate Filament Bundle Assembly Negative Regulation Of Epithelial Cell Proliferation Negative Regulation Of Keratinocyte Migration Negative Regulation Of Wound Healing Regulation Of Epithelium Regeneration
Pathways
Drugs
Diseases
GWAS		Knee osteoarthritis ( 28916551) Multiple sclerosis ( 31604244)
Novel Interacting Genes		1 novel interacting genes: STK4
Interacting Genes		4 interacting genes: EGFR RNF10 SUMO2 UCHL5
Entrez ID		83481
HPRD ID		06500
Ensembl ID		ENSG00000261150
Uniprot IDs		P58107
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Peptidyl-serine Phosphorylation Positive Regulation Of Peptidyl-serine Phosphorylation Regulation Of Protein Catabolic Process Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of DNA Repair Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Embryonic Organ Development Positive Regulation Of Protein Kinase C Signaling Positive Regulation Of DNA-templated Transcription Regulation Of DNA Replication Epidermal Growth Factor Receptor Activity Negative Regulation Of Protein Catabolic Process Shc-EGFR Complex Positive Regulation Of RNA Metabolic Process Regulation Of Protein Metabolic Process Multivesicular Body, Internal Vesicle Lumen Protein Modification Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Hepatocyte Apoptotic Process Positive Regulation Of Substrate-dependent Cell Migration, Cell Attachment To Substrate Positive Regulation Of Protein Metabolic Process Epithelial Cell Proliferation Epidermal Growth Factor Binding Cell Morphogenesis Post-translational Protein Modification Regulation Of Ubiquitin-dependent Protein Catabolic Process Primitive Hemopoiesis Regulation Of Protein Kinase C Signaling Regulation Of Proteasomal Protein Catabolic Process Regulation Of Cell Differentiation Involved In Embryonic Placenta Development Endocardium Development Postsynapse To Nucleus Signaling Pathway Extrinsic Component Of Postsynaptic Density Membrane Negative Regulation Of Developmental Process Regulation Of DNA Repair Positive Regulation Of Protein Phosphorylation Regulation Of Developmental Process Regulation Of Primary Metabolic Process Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Phosphorylation Positive Regulation Of Macromolecule Biosynthetic Process ERBB2-EGFR Signaling Pathway Negative Regulation Of Schwann Cell Proliferation Positive Regulation Of Biosynthetic Process Positive Regulation Of DNA Metabolic Process Neural Tube Formation Ribosome-associated Ubiquitin-dependent Protein Catabolic Process Forebrain Morphogenesis
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