CAST and CAPN1

Number of citations of the paper that reports this interaction (PubMedID 33961781)
97

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, affinity chromatography technology)
HPRD (in vitro)

		CAST	CAPN1
Description		calpastatin	calpain 1
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Cytosol Membrane	Cornified Envelope Extracellular Region Cytoplasm Mitochondrion Lysosome Cytosol Plasma Membrane Focal Adhesion Membrane Extracellular Exosome Calpain Complex Ficolin-1-rich Granule Lumen
	Molecular Function	RNA Binding Endopeptidase Inhibitor Activity Cysteine-type Endopeptidase Inhibitor Activity Protein Binding Calcium-dependent Cysteine-type Endopeptidase Inhibitor Activity Peptidase Inhibitor Activity Cadherin Binding	Calcium-dependent Cysteine-type Endopeptidase Activity Calcium Ion Binding Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity Metal Ion Binding
	Biological Process	Presynaptic Active Zone Organization Negative Regulation Of Type B Pancreatic Cell Apoptotic Process	Proteolysis Positive Regulation Of Cell Population Proliferation Regulation Of Macroautophagy Receptor Catabolic Process Regulation Of Catalytic Activity Mammary Gland Involution Self Proteolysis NMDA Selective Glutamate Receptor Signaling Pathway
Pathways		Degradation of the extracellular matrix Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models	Degradation of the extracellular matrix Degradation of the extracellular matrix Neutrophil degranulation Formation of the cornified envelope Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
Drugs		Calcium Artenimol	4-[[(2S)-2-[[(2S)-3-Carboxy-2-hydroxypropanoyl]amino]-4-methylpentanoyl]amino]butyl-(diaminomethylidene)azanium N-[(benzyloxy)carbonyl]-L-leucyl-N-[(1S)-3-fluoro-1-(4-hydroxybenzyl)-2-oxopropyl]-L-leucinamide (2S)-4-METHYL-2-(3-PHENYLTHIOUREIDO)-N-((3S)-TETRAHYDRO-2-HYDROXY-3-FURANYL)PENTANAMIDE
Diseases
GWAS		Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL) ( 28090653) Alcohol dependence ( 19581569) Appendicular lean mass ( 33097823) Body mass index ( 26426971 29381148) Fish- and plant-related diet ( 32066663) Medication use (agents acting on the renin-angiotensin system) ( 31015401)	Urate levels ( 31578528)
Interacting Genes		11 interacting genes: CAPN1 CAPNS1 CASP1 CASP3 CASP7 HTRA1 PPFIA1 PPFIA2 PPFIA3 PPFIA4 SUMO2	55 interacting genes: ACTC1 ACTN2 ARF6 ATG5 ATXN3 BCL2L1 BID CAPNS1 CASP14 CAST CBL CDK5R1 CLEC4G COL1A1 COL3A1 CREG1 CTSC DES ECHS1 F2R F2RL1 FANCA FANCG FHL2 GNG12 GPT GRIN2B HNRNPD IL1A INPP4A ITGB3 KCTD7 KNG1 LAMTOR1 MAPT MYBPC3 NDUFB7 NFE2L1 NFKBIA PRMT5 PSEN2 PTGDS RAD21 SH3BGR SLC22A1 SLIT3 SPTAN1 SPTBN1 STAT3 SYNE1 TINAGL1 TLE5 TP53 UFSP2 VIM
Entrez ID		831	823
HPRD ID		00233	00253
Ensembl ID		ENSG00000310517	ENSG00000014216
Uniprot IDs		A0A6Q8PH20 B7Z6N0 E9PCH5 E9PDE4 P20810 Q59HE3 Q86YM9	B2RDI5 B4DWH5 P07384
PDB IDs			1ZCM 2ARY 7W7O 7X79 8GX3
Enriched GO Terms of Interacting Partners?		Presynaptic Active Zone Protein Poly-ADP-ribosylation Calpain Complex Cysteine-type Peptidase Activity Pyroptotic Inflammatory Response Cellular Response To Staurosporine Peptidase Activity Cysteine-type Endopeptidase Activity Synapse Organization Calcium-dependent Cysteine-type Endopeptidase Activity Fibroblast Apoptotic Process Proteolysis Interleukin-18-mediated Signaling Pathway Cytosol Aspartic-type Endopeptidase Activity Execution Phase Of Apoptosis Plasma Membrane Repair Cell Junction Organization Protein Processing Regulation Of Macroautophagy Cellular Response To Alkaloid Glutamatergic Synapse Cellular Response To Osmotic Stress Leukocyte Apoptotic Process Ceramide Biosynthetic Process Structural Constituent Of Presynapse Epididymosome Protein Metabolic Process Cytoplasm Protein Maturation Response To Lipopolysaccharide Positive Regulation Of Neuron Apoptotic Process Striated Muscle Cell Differentiation Response To Osmotic Stress Response To Molecule Of Bacterial Origin AIM2 Inflammasome Complex Assembly Protease Inhibitor Complex Phospholipase A2 Activator Activity Regulation Of Autophagy Ceramide Metabolic Process Post-translational Protein Modification Endopeptidase Activity Response To Alkaloid Sphingolipid Biosynthetic Process AIM2 Inflammasome Complex IPAF Inflammasome Complex Intrinsic Apoptotic Signaling Pathway In Response To Osmotic Stress Structural Constituent Of Postsynaptic Density Hydrolase Activity Cell Death	Organelle Organization Regulation Of Programmed Cell Death Response To Alcohol Regulation Of Organelle Organization Regulation Of Apoptotic Process Identical Protein Binding Positive Regulation Of Organelle Organization Regulation Of Multicellular Organismal Process Protease Binding Cytoplasm Regulation Of Signal Transduction Regulation Of Cellular Component Organization Developmental Process Regulation Of Cell Communication Regulation Of Signaling Cellular Response To Amino Acid Stimulus Positive Regulation Of Gene Expression Response To Lipid Positive Regulation Of Programmed Cell Death Negative Regulation Of MiRNA-mediated Gene Silencing Negative Regulation Of Post-transcriptional Gene Silencing By Regulatory NcRNA Negative Regulation Of Gene Expression Regulation Of Intracellular Signal Transduction Hepatocyte Apoptotic Process Cytosol Regulation Of Actin Filament Depolymerization Negative Regulation Of Apoptotic Process Cell Junction Maintenance Regulation Of Renin Secretion Into Blood Stream Regulation Of Autophagy Sarcomere Negative Regulation Of Programmed Cell Death Regulation Of Actin Filament-based Process Regulation Of Mitochondrial Membrane Permeability G-protein Beta-subunit Binding Regulation Of Protein Localization Response To Amino Acid Release Of Cytochrome C From Mitochondria Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Positive Regulation Of Signal Transduction Response To Fluoride Regulation Of Protein-containing Complex Disassembly Positive Regulation Of Apoptotic Process Cellular Component Maintenance Regulation Of Membrane Permeability Cysteine-type Peptidase Activity Positive Regulation Of Cellular Component Organization Regulation Of MiRNA-mediated Gene Silencing Negative Regulation Of Protein Localization
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