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CAST and CASP7
Number of citations of the paper that reports this interaction (PubMedID
10731697
)
0
Data Source:
HPRD
(in vitro)
CAST
CASP7
Description
calpastatin
caspase 7
Image
No pdb structure
GO Annotations
Cellular Component
Cytoplasm
Endoplasmic Reticulum
Cytosol
Membrane
Fibrillar Center
Extracellular Region
Extracellular Space
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Plasma Membrane
Molecular Function
RNA Binding
Endopeptidase Inhibitor Activity
Cysteine-type Endopeptidase Inhibitor Activity
Protein Binding
Calcium-dependent Cysteine-type Endopeptidase Inhibitor Activity
Peptidase Inhibitor Activity
Cadherin Binding
RNA Binding
Catalytic Activity
Aspartic-type Endopeptidase Activity
Cysteine-type Endopeptidase Activity
Protein Binding
Peptidase Activity
Cysteine-type Peptidase Activity
Hydrolase Activity
Biological Process
Presynaptic Active Zone Organization
Negative Regulation Of Type B Pancreatic Cell Apoptotic Process
Negative Regulation Of Transcription By RNA Polymerase II
Plasma Membrane Repair
Regulation Of Transcription By RNA Polymerase II
Proteolysis
Apoptotic Process
Heart Development
Response To UV
Protein Processing
Protein Catabolic Process
Defense Response To Bacterium
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Positive Regulation Of Neuron Apoptotic Process
Fibroblast Apoptotic Process
Ceramide Biosynthetic Process
Striated Muscle Cell Differentiation
Neuron Apoptotic Process
Protein Maturation
Protein Poly-ADP-ribosylation
Lymphocyte Apoptotic Process
Pyroptotic Inflammatory Response
Cellular Response To Lipopolysaccharide
Leukocyte Apoptotic Process
Cellular Response To Staurosporine
Execution Phase Of Apoptosis
Positive Regulation Of Plasma Membrane Repair
Pathways
Degradation of the extracellular matrix
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
Activation of caspases through apoptosome-mediated cleavage
SMAC (DIABLO) binds to IAPs
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes
Apoptotic cleavage of cellular proteins
SMAC, XIAP-regulated apoptotic response
Caspase-mediated cleavage of cytoskeletal proteins
Drugs
Calcium
Artenimol
Fica
Emricasan
Incadronic acid
Diseases
GWAS
Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL) (
28090653
)
Alcohol dependence (
19581569
)
Appendicular lean mass (
33097823
)
Body mass index (
26426971
29381148
)
Fish- and plant-related diet (
32066663
)
Medication use (agents acting on the renin-angiotensin system) (
31015401
)
Cataracts (
34127677
)
Smoking status (ever vs never smokers) (
30643258
)
Vitiligo (
22561518
27723757
)
Interacting Genes
11 interacting genes:
CAPN1
CAPNS1
CASP1
CASP3
CASP7
HTRA1
PPFIA1
PPFIA2
PPFIA3
PPFIA4
SUMO2
63 interacting genes:
AR
ARHGDIA
BIRC2
BIRC3
BIRC5
BIRC7
CASP10
CASP2
CASP3
CASP8
CASP9
CAST
CDC42
CFLAR
CLSPN
COPS6
CTSG
DCTN1
DFFA
DSP
EIF2AK2
GOLGA3
GORASP1
GZMB
HNRNPH1
HSPA5
KRT18
LYN
MAGEA11
MAPT
MAX
MEF2A
MEF2D
NEDD4
NIF3L1
PARP1
PLA2G4B
PRKCZ
PSEN1
PSEN2
PSIP1
PSME3
PTGES3
PTMA
RAC1
RAD21
RAD51
RASA1
RB1
RNF7
ROCK1
SAT1
SP1
SPTAN1
SRF
STAT1
STK24
TERF1
TNFRSF1A
TRIM25
UBE4B
VIM
XIAP
Entrez ID
831
840
HPRD ID
00233
03457
Ensembl ID
ENSG00000310517
ENSG00000165806
Uniprot IDs
A0A6Q8PH20
B7Z6N0
E9PCH5
E9PDE4
P20810
Q59HE3
Q86YM9
A0A0A0MRL7
B4DWA2
P55210
PDB IDs
1F1J
1GQF
1I4O
1I51
1K86
1K88
1KMC
1SHJ
1SHL
2QL5
2QL7
2QL9
2QLB
2QLF
2QLJ
3EDR
3H1P
3IBC
3IBF
3R5K
4FDL
4FEA
4HQ0
4HQR
4JB8
4JJ8
4JR1
4JR2
4LSZ
4ZVO
4ZVP
4ZVQ
4ZVR
4ZVS
4ZVT
4ZVU
5IC6
5K20
5V6U
5V6Z
7WZS
8DGZ
8DJ3
Enriched GO Terms of Interacting Partners
?
Presynaptic Active Zone
Protein Poly-ADP-ribosylation
Calpain Complex
Cysteine-type Peptidase Activity
Pyroptotic Inflammatory Response
Cellular Response To Staurosporine
Peptidase Activity
Cysteine-type Endopeptidase Activity
Synapse Organization
Calcium-dependent Cysteine-type Endopeptidase Activity
Fibroblast Apoptotic Process
Proteolysis
Interleukin-18-mediated Signaling Pathway
Cytosol
Aspartic-type Endopeptidase Activity
Execution Phase Of Apoptosis
Plasma Membrane Repair
Cell Junction Organization
Protein Processing
Regulation Of Macroautophagy
Cellular Response To Alkaloid
Glutamatergic Synapse
Cellular Response To Osmotic Stress
Leukocyte Apoptotic Process
Ceramide Biosynthetic Process
Structural Constituent Of Presynapse
Epididymosome
Protein Metabolic Process
Cytoplasm
Protein Maturation
Response To Lipopolysaccharide
Positive Regulation Of Neuron Apoptotic Process
Striated Muscle Cell Differentiation
Response To Osmotic Stress
Response To Molecule Of Bacterial Origin
AIM2 Inflammasome Complex Assembly
Protease Inhibitor Complex
Phospholipase A2 Activator Activity
Regulation Of Autophagy
Ceramide Metabolic Process
Post-translational Protein Modification
Endopeptidase Activity
Response To Alkaloid
Sphingolipid Biosynthetic Process
AIM2 Inflammasome Complex
IPAF Inflammasome Complex
Intrinsic Apoptotic Signaling Pathway In Response To Osmotic Stress
Structural Constituent Of Postsynaptic Density
Hydrolase Activity
Cell Death
Regulation Of Apoptotic Process
Regulation Of Programmed Cell Death
Apoptotic Process
Programmed Cell Death
Cell Death
Cytosol
Negative Regulation Of Programmed Cell Death
Negative Regulation Of Apoptotic Process
Nucleus
Cytoplasm
Intracellular Signal Transduction
Enzyme Binding
Regulation Of Primary Metabolic Process
Negative Regulation Of Cellular Component Organization
Protein-containing Complex
Positive Regulation Of Macromolecule Metabolic Process
Response To Stress
Execution Phase Of Apoptosis
Macromolecule Metabolic Process
Positive Regulation Of Metabolic Process
Regulation Of Macromolecule Metabolic Process
Regulation Of Neuron Apoptotic Process
Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process
Regulation Of Cellular Component Organization
Regulation Of Metabolic Process
Regulation Of Signal Transduction
Regulation Of Intracellular Signal Transduction
Positive Regulation Of Intracellular Signal Transduction
Signal Transduction
Cellular Response To Stress
Myeloid Cell Differentiation
Positive Regulation Of Signal Transduction
Positive Regulation Of Signaling
Regulation Of Protein-containing Complex Assembly
Regulation Of Signaling
Regulation Of Cell Communication
Regulation Of Necroptotic Process
Protein Metabolic Process
Cysteine-type Endopeptidase Activity
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Proteolysis
Positive Regulation Of Neuron Apoptotic Process
Positive Regulation Of Cell Communication
Protein Maturation
Regulation Of Programmed Necrotic Cell Death
Regulation Of Canonical NF-kappaB Signal Transduction
Apoptotic Signaling Pathway
Regulation Of Protein Metabolic Process
DNA-binding Transcription Factor Binding
Protein Processing
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Tagcloud (Intersection)
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