IL1A and CASP1

Number of citations of the paper that reports this interaction (PMID 18329368)
170

Data Source:
HPRD (in vivo)

		IL1A	CASP1
Gene Name		interleukin 1, alpha	caspase 1, apoptosis-related cysteine peptidase
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Cytosol	Extracellular Region Cytoplasm Cytosol IPAF Inflammasome Complex NLRP1 Inflammasome Complex NLRP3 Inflammasome Complex AIM2 Inflammasome Complex
	Molecular Function	Cytokine Activity Interleukin-1 Receptor Binding Copper Ion Binding Protein Binding	Endopeptidase Activity Cysteine-type Endopeptidase Activity Protein Binding Cysteine-type Endopeptidase Activator Activity Involved In Apoptotic Process
	Biological Process	Fever Generation Connective Tissue Replacement Involved In Inflammatory Response Wound Healing Apoptotic Process Inflammatory Response Immune Response Cell Proliferation Negative Regulation Of Cell Proliferation Positive Regulation Vascular Endothelial Growth Factor Production Cytokine-mediated Signaling Pathway Cellular Response To Heat Ectopic Germ Cell Programmed Cell Death Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Interleukin-2 Biosynthetic Process Positive Regulation Of Angiogenesis Positive Regulation Of Mitotic Nuclear Division Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of JNK Cascade Response To Copper Ion Positive Regulation Of Cytokine Secretion Positive Regulation Of ERK1 And ERK2 Cascade Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	Response To Hypoxia Proteolysis Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Signal Transduction Regulation Of Autophagy Response To Lipopolysaccharide Interleukin-1 Beta Production Response To ATP Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Innate Immune Response Positive Regulation Of Interleukin-1 Alpha Secretion Positive Regulation Of Interleukin-1 Beta Secretion Regulation Of Inflammatory Response Mitochondrial Depolarization Membrane Hyperpolarization Pyroptosis Cellular Response To Mechanical Stimulus Cellular Response To Organic Substance Execution Phase Of Apoptosis Programmed Necrotic Cell Death Toxin Transport
Pathways		Signaling by Interleukins Interleukin-1 processing Cellular Senescence Interleukin-1 signaling Senescence-Associated Secretory Phenotype (SASP) Cytokine Signaling in Immune system	Signaling by Interleukins The NLRP3 inflammasome Inflammasomes NOD1/2 Signaling Pathway The AIM2 inflammasome Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways Interleukin-1 processing The IPAF inflammasome Cytokine Signaling in Immune system Innate Immune System
Drugs			Minocycline 1-METHYL-3-TRIFLUOROMETHYL-1H-THIENO[2,3-C]PYRAZOLE-5-CARBOXYLIC ACID (2-MERCAPTO-ETHYL)-AMIDE 3-[2-(2-BENZYLOXYCARBONYLAMINO-3-METHYL-BUTYRYLAMINO)-PROPIONYLAMINO]-4-OXO-PENTANOIC ACID 3-{6-[(8-HYDROXY-QUINOLINE-2-CARBONYL)-AMINO]-2-THIOPHEN-2-YL-HEXANOYLAMINO}-4-OXO-BUTYRI ACID
Diseases
GWAS		Endometriosis ( 20844546) Working memory ( 21107309)
Protein-Protein Interactions		9 interactors: CAPN1 CASP1 HAX1 IL1R1 IL1R2 IL1RAP NDN NFKBIE S100A13	42 interactors: AR ATN1 ATXN3 BCAP31 BCL2L1 BID CARD16 CARD17 CARD8 CASP10 CASP14 CASP4 CASP8 CAST CDK11B EGFR FGF2 HTT IL18 IL1A IL1B IL33 IL37 LMNA MAPT NEDD4 NFE2L2 NLRC4 NLRP1 NOD1 PAK1 PARK2 PARP1 PLA2G4A PLA2G4B PSEN1 PSEN2 PYCARD RIPK2 TFAP2A TIRAP VAC14
Entrez ID		3552	834
HPRD ID		00988	00977
Ensembl ID			ENSG00000137752
Uniprot IDs		P01583	A8K249 A8K257 P29466
PDB IDs		1ITA 2ILA 2KKI 2L5X	1BMQ 1IBC 1ICE 1RWK 1RWM 1RWN 1RWO 1RWP 1RWV 1RWW 1RWX 1SC1 1SC3 1SC4 2FQQ 2H48 2H4W 2H4Y 2H51 2H54 2HBQ 2HBR 2HBY 2HBZ 3D6F 3D6H 3D6M 3E4C 3NS7
Enriched GO Terms of Interacting Partners?		Cytokine Production Cellular Response To Organic Substance Cellular Response To Cytokine Stimulus Immune Response Response To Cytokine Response To Organic Substance Interleukin-1 Alpha Secretion Cytokine-mediated Signaling Pathway Immune System Process Regulation Of Autophagy D-serine Transport Mitochondrial Depolarization Positive Regulation Of Interleukin-1 Alpha Secretion Regulation Of Protein Transport Regulation Of Protein Targeting To Mitochondrion Interleukin-2 Biosynthetic Process Regulation Of Establishment Of Protein Localization Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of Cellular Process Positive Regulation Of Interleukin-1 Alpha Production Pyroptosis Interleukin-1 Secretion Regulation Of Protein Localization Positive Regulation Of Intracellular Signal Transduction Interleukin-2 Production Positive Regulation Of Granulocyte Differentiation Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of Mitochondrion Degradation Regulation Of Intracellular Protein Transport Interleukin-1-mediated Signaling Pathway Regulation Of Inflammatory Response Interleukin-1 Beta Production Receptor Catabolic Process Regulation Of Cellular Localization Positive Regulation Of Actin Cytoskeleton Reorganization Respiratory System Process Positive Regulation Of Interleukin-1 Beta Secretion Positive Regulation Of Interleukin-1 Secretion Cytoplasmic Sequestering Of Transcription Factor Cytokine Biosynthetic Process Response To Copper Ion Regulation Of Interleukin-1 Beta Secretion Axonal Fasciculation Cytoplasmic Sequestering Of Protein Positive Regulation Of Signal Transduction Response To Stimulus Mast Cell Degranulation	Apoptotic Process Programmed Cell Death Regulation Of Cell Death Cell Death Death Regulation Of Apoptotic Process Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Protein Metabolic Process Positive Regulation Of Signal Transduction Regulation Of Protein Metabolic Process Regulation Of Signal Transduction Response To Stress Immune Response Signaling Regulation Of Signaling Cell Communication Positive Regulation Of Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Proteolysis Cellular Response To Stimulus Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Regulation Of Intracellular Signal Transduction Regulation Of I-kappaB Kinase/NF-kappaB Signaling Response To Organic Substance Negative Regulation Of Cell Death Regulation Of Proteolysis Positive Regulation Of Cellular Metabolic Process Regulation Of Cellular Process Regulation Of Cellular Localization Cellular Response To Organic Substance Regulation Of Catalytic Activity Positive Regulation Of Apoptotic Process Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Positive Regulation Of Programmed Cell Death Immune System Process Signal Transduction Positive Regulation Of Cell Death Negative Regulation Of Programmed Cell Death Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Protein Localization Regulation Of Establishment Of Protein Localization Protein Processing Negative Regulation Of Apoptotic Signaling Pathway Negative Regulation Of Signal Transduction Negative Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Defense Response Positive Regulation Of Cysteine-type Endopeptidase Activity
Tagcloud ?		45mg amenable copy curative cytokine dacomitinib eligible endpoint evaluable exploratory forty goals harboring her4 il1b il4 il6 il8 irreversible manageable p16ink4a pfs pi3k pik3ca platinum progressed recistv1 scchn shorter	10ko acp5 aia arthritic arthritis autoinflammatory blockade driven erosions ex exogenous focal hence histological histopathology il1b il33 inflammasome investigative joint neutralization nlrp3 osteoclast osteoclastogenesis pathology radiographic synovial synovium tartrate
Tagcloud (Difference) ?		45mg amenable copy curative cytokine dacomitinib eligible endpoint evaluable exploratory forty goals harboring her4 il4 il6 il8 irreversible manageable p16ink4a pfs pi3k pik3ca platinum progressed recistv1 scchn shorter	10ko acp5 aia arthritic arthritis autoinflammatory blockade driven erosions ex exogenous focal hence histological histopathology il33 inflammasome investigative joint neutralization nlrp3 osteoclast osteoclastogenesis pathology radiographic synovial synovium tartrate
Tagcloud (Intersection) ?		il1b