IL1A and NDN

Number of citations: 41 (PubMedID 12913118)
Data Source: HPRD (two hybrid, in vitro)

		IL1A	NDN
Name		interleukin 1 alpha	necdin, MAGE family member
Structure			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Cytoplasm Cytosol	Nucleus Nucleoplasm Cytoplasm Centrosome Cytosol Protein-containing Complex Cell Projection Perikaryon
	Molecular Function	Cytokine Activity Interleukin-1 Receptor Binding Copper Ion Binding Protein Binding	DNA Binding Protein Binding Gamma-tubulin Binding Promoter-specific Chromatin Binding
	Biological Process	Fever Generation Positive Regulation Of Cytokine Production Connective Tissue Replacement Involved In Inflammatory Response Wound Healing Intracellular Sodium Ion Homeostasis Apoptotic Process Response To Stress Inflammatory Response Immune Response Negative Regulation Of Cell Population Proliferation Positive Regulation Of Vascular Endothelial Growth Factor Production Positive Regulation Of Gene Expression Cytokine-mediated Signaling Pathway Positive Regulation Of Interleukin-2 Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Immature T Cell Proliferation In Thymus Cellular Response To Heat Ectopic Germ Cell Programmed Cell Death Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Angiogenesis Positive Regulation Of Mitotic Nuclear Division Positive Regulation Of Transcription By RNA Polymerase II Response To Copper Ion Positive Regulation Of Protein Secretion Positive Regulation Of Cell Division Regulation Of ERK1 And ERK2 Cascade Cellular Response To Lipopolysaccharide Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	Negative Regulation Of Transcription By RNA Polymerase II Neuron Migration Respiratory System Process Regulation Of DNA-templated Transcription Axonogenesis Axonal Fasciculation Central Nervous System Development Respiratory Gaseous Exchange By Respiratory System Glial Cell Migration Post-embryonic Development Sensory Perception Of Pain Neuron Differentiation Positive Regulation Of Transcription By RNA Polymerase II Neurotrophin TRK Receptor Signaling Pathway Neuron Development Axon Extension Multicellular Organismal-level Homeostasis Genomic Imprinting
Pathways		Senescence-Associated Secretory Phenotype (SASP) Interleukin-1 processing Pyroptosis Interleukin-10 signaling Interleukin-4 and Interleukin-13 signaling Interleukin-1 signaling Purinergic signaling in leishmaniasis infection	Interleukin-4 and Interleukin-13 signaling
Drugs		Rilonacept	None
Diseases		Graft-versus-host disease	Prader-Willi and Angelman syndromes, including: Angelman syndrome (AS); Prader-Willi syndrome (PWS)
GWAS		Dysmenorrheic pain severity ( 29855537 ) Endometriosis ( 20844546 28537267 ) Gestational age at birth (child effect) ( 31477735 ) Interleukin-1-receptor antagonist levels ( 22205395 ) Neutrophil count ( 32888494 ) Neutrophil percentage of white cells ( 32888494 ) Post-term birth ( 31477735 ) Response to antipsychotic treatment in schizophrenia (working memory) ( 21107309 )	Body size at age 10 ( 32376654 ) Depressive symptoms (SSRI exposure interaction) ( 25649181 ) HDL cholesterol levels ( 32203549 ) Parkinson's disease (age of onset) ( 33884653 ) Plasma anti-thyroid peroxidase levels ( 29678681 ) Serum metabolite concentrations in chronic kidney disease ( 29545352 )
Interacting Genes		11 interacting genes: CAPN1 CASP1 HAX1 IL1R1 IL1R2 IL1RAP KPNA6 MEOX2 NDN NFKBIE S100A13	47 interacting genes: APBB1IP ARSL BLOC1S6 CALCOCO2 CCDC136 CDR2 DTNBP1 E2F1 E2F4 EEF1AKMT1 EGFR EID1 EPAS1 FAM131C FSD2 FXR2 GKAP1 GOLGA2 HIF1A HNRNPU IFFO1 IL1A IL32 IRS4 LAX1 LPXN MIER2 MKRN2 MYG1 NEFL NGFR NUBP1 NUCB1 NUCB2 P4HA3 PALS2 PJA1 PPARGC1A PPFIA1 SERTAD3 SIRT1 SSX2IP TFIP11 TP53 U2AF1 ZBTB1 ZBTB7B
Entrez ID		3552	4692
HPRD ID		00988	03667
Ensembl ID		ENSG00000115008	ENSG00000182636
Uniprot IDs		P01583	Q99608 X5D982
PDB IDs		2ILA 2KKI 2L5X 5UC6	Not available
GO Terms Enriched among Interactors		Interleukin-1 Binding Interleukin-1 Receptor Activity Interleukin-1-mediated Signaling Pathway Cytokine-mediated Signaling Pathway Regulation Of Cytokine Production Positive Regulation Of Cytokine Production Regulation Of Interleukin-1-mediated Signaling Pathway Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process NAD+ Nucleosidase Activity, Cyclic ADP-ribose Generating Regulation Of Interleukin-1 Production Cell Surface Receptor Signaling Pathway Positive Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Regulation Of Cytokine-mediated Signaling Pathway Positive Regulation Of Metabolic Process Positive Regulation Of Multicellular Organismal Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Gene Expression Positive Regulation Of Interleukin-1-mediated Signaling Pathway Interleukin-1, Type II, Blocking Receptor Activity Positive Regulation Of Cytokine-mediated Signaling Pathway Regulation Of Multicellular Organismal Process Positive Regulation Of Interleukin-1 Production Positive Regulation Of Response To Cytokine Stimulus Regulation Of Macromolecule Metabolic Process Regulation Of Canonical NF-kappaB Signal Transduction AIM2 Inflammasome Complex Assembly Protease Inhibitor Complex Interleukin-1, Type I, Activating Receptor Activity Interleukin-33 Receptor Activity Regulation Of Cytokine Production Involved In Inflammatory Response Negative Regulation Of Interleukin-1 Alpha Production Entry Of Viral Genome Into Host Nucleus Through Nuclear Pore Complex Via Importin AIM2 Inflammasome Complex IPAF Inflammasome Complex Calpain Complex Viral Penetration Into Host Nucleus Mammary Gland Involution Cysteine-type Peptidase Activity Cytokine Precursor Processing Positive Regulation Of Neutrophil Extravasation Somite Specification Granulocyte Colony-stimulating Factor Signaling Pathway NMDA Selective Glutamate Receptor Signaling Pathway Osmosensory Signaling Pathway NLRP3 Inflammasome Complex Response To Peptide	Cis-regulatory Region Sequence-specific DNA Binding Axo-dendritic Transport Circadian Rhythm Transport Along Microtubule Cellular Response To Hypoxia Positive Regulation Of MiRNA Metabolic Process Positive Regulation Of MiRNA Transcription Neuron Apoptotic Process Cytoskeleton-dependent Intracellular Transport Axon Cytoplasm Microtubule-based Transport Axonal Transport Circadian Regulation Of Gene Expression Regulation Of Brown Fat Cell Differentiation Positive Regulation Of Insulin Receptor Signaling Pathway Positive Regulation Of Cellular Response To Insulin Stimulus Cytoplasm Cellular Response To Decreased Oxygen Levels DNA-binding Transcription Activator Activity Promoter-specific Chromatin Binding Embryonic Placenta Development Cellular Homeostasis Regulation Of MiRNA Transcription Positive Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Connective Tissue Replacement Involved In Inflammatory Response Wound Healing Rhythmic Process Cellular Response To Oxygen Levels Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Regulation Of MiRNA Metabolic Process Intracellular Chemical Homeostasis Organelle Transport Along Microtubule Intracellular Glucose Homeostasis Regulation Of Fibroblast Proliferation Positive Regulation Of Biosynthetic Process Stress-induced Premature Senescence Positive Regulation Of Nucleobase-containing Compound Metabolic Process Protein-containing Complex MRNA Metabolic Process PML Body Anterograde Axonal Transport Nuclear Receptor Binding Connective Tissue Replacement Microtubule-based Process Intracellular Oxygen Homeostasis Regulation Of Attachment Of Mitotic Spindle Microtubules To Kinetochore Positive Regulation Of Gene Expression Protein Domain Specific Binding