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IL1A and CAPN1
Number of citations of the paper that reports this interaction (PubMedID
7499244
)
0
Data Source:
HPRD
(in vitro)
IL1A
CAPN1
Description
interleukin 1 alpha
calpain 1
Image
GO Annotations
Cellular Component
Extracellular Region
Extracellular Space
Nucleus
Cytoplasm
Cytosol
Cornified Envelope
Extracellular Region
Cytoplasm
Mitochondrion
Lysosome
Cytosol
Plasma Membrane
Focal Adhesion
Membrane
Extracellular Exosome
Calpain Complex
Ficolin-1-rich Granule Lumen
Molecular Function
Cytokine Activity
Interleukin-1 Receptor Binding
Copper Ion Binding
Protein Binding
Calcium-dependent Cysteine-type Endopeptidase Activity
Calcium Ion Binding
Protein Binding
Peptidase Activity
Cysteine-type Peptidase Activity
Hydrolase Activity
Metal Ion Binding
Biological Process
Fever Generation
Positive Regulation Of Cytokine Production
Connective Tissue Replacement Involved In Inflammatory Response Wound Healing
Intracellular Sodium Ion Homeostasis
Apoptotic Process
Response To Stress
Inflammatory Response
Immune Response
Negative Regulation Of Cell Population Proliferation
Positive Regulation Of Vascular Endothelial Growth Factor Production
Positive Regulation Of Gene Expression
Cytokine-mediated Signaling Pathway
Positive Regulation Of Interleukin-2 Production
Positive Regulation Of Interleukin-6 Production
Positive Regulation Of Tumor Necrosis Factor Production
Positive Regulation Of Immature T Cell Proliferation In Thymus
Cellular Response To Heat
Ectopic Germ Cell Programmed Cell Death
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Positive Regulation Of Angiogenesis
Positive Regulation Of Mitotic Nuclear Division
Positive Regulation Of Transcription By RNA Polymerase II
Response To Copper Ion
Positive Regulation Of Protein Secretion
Positive Regulation Of Cell Division
Regulation Of ERK1 And ERK2 Cascade
Cellular Response To Lipopolysaccharide
Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Proteolysis
Positive Regulation Of Cell Population Proliferation
Regulation Of Macroautophagy
Receptor Catabolic Process
Regulation Of Catalytic Activity
Mammary Gland Involution
Self Proteolysis
NMDA Selective Glutamate Receptor Signaling Pathway
Pathways
Senescence-Associated Secretory Phenotype (SASP)
Interleukin-1 processing
Pyroptosis
Interleukin-10 signaling
Interleukin-4 and Interleukin-13 signaling
Interleukin-1 signaling
Purinergic signaling in leishmaniasis infection
Degradation of the extracellular matrix
Degradation of the extracellular matrix
Neutrophil degranulation
Formation of the cornified envelope
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
Drugs
Rilonacept
4-[[(2S)-2-[[(2S)-3-Carboxy-2-hydroxypropanoyl]amino]-4-methylpentanoyl]amino]butyl-(diaminomethylidene)azanium
N-[(benzyloxy)carbonyl]-L-leucyl-N-[(1S)-3-fluoro-1-(4-hydroxybenzyl)-2-oxopropyl]-L-leucinamide
(2S)-4-METHYL-2-(3-PHENYLTHIOUREIDO)-N-((3S)-TETRAHYDRO-2-HYDROXY-3-FURANYL)PENTANAMIDE
Diseases
Graft-versus-host disease
GWAS
Dysmenorrheic pain severity (
29855537
)
Endometriosis (
20844546
28537267
)
Gestational age at birth (child effect) (
31477735
)
Interleukin-1-receptor antagonist levels (
22205395
)
Neutrophil count (
32888494
)
Neutrophil percentage of white cells (
32888494
)
Post-term birth (
31477735
)
Response to antipsychotic treatment in schizophrenia (working memory) (
21107309
)
Urate levels (
31578528
)
Interacting Genes
11 interacting genes:
CAPN1
CASP1
HAX1
IL1R1
IL1R2
IL1RAP
KPNA6
MEOX2
NDN
NFKBIE
S100A13
55 interacting genes:
ACTC1
ACTN2
ARF6
ATG5
ATXN3
BCL2L1
BID
CAPNS1
CASP14
CAST
CBL
CDK5R1
CLEC4G
COL1A1
COL3A1
CREG1
CTSC
DES
ECHS1
F2R
F2RL1
FANCA
FANCG
FHL2
GNG12
GPT
GRIN2B
HNRNPD
IL1A
INPP4A
ITGB3
KCTD7
KNG1
LAMTOR1
MAPT
MYBPC3
NDUFB7
NFE2L1
NFKBIA
PRMT5
PSEN2
PTGDS
RAD21
SH3BGR
SLC22A1
SLIT3
SPTAN1
SPTBN1
STAT3
SYNE1
TINAGL1
TLE5
TP53
UFSP2
VIM
Entrez ID
3552
823
HPRD ID
00988
00253
Ensembl ID
ENSG00000115008
ENSG00000014216
Uniprot IDs
P01583
B2RDI5
B4DWH5
P07384
PDB IDs
2ILA
2KKI
2L5X
5UC6
1ZCM
2ARY
7W7O
7X79
8GX3
Enriched GO Terms of Interacting Partners
?
Interleukin-1 Binding
Interleukin-1 Receptor Activity
Interleukin-1-mediated Signaling Pathway
Cytokine-mediated Signaling Pathway
Regulation Of Cytokine Production
Positive Regulation Of Cytokine Production
Regulation Of Interleukin-1-mediated Signaling Pathway
Positive Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Biosynthetic Process
NAD+ Nucleosidase Activity, Cyclic ADP-ribose Generating
Regulation Of Interleukin-1 Production
Cell Surface Receptor Signaling Pathway
Positive Regulation Of Macromolecule Metabolic Process
Regulation Of Metabolic Process
Regulation Of Cytokine-mediated Signaling Pathway
Positive Regulation Of Metabolic Process
Positive Regulation Of Multicellular Organismal Process
Regulation Of Gene Expression
Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Positive Regulation Of Gene Expression
Positive Regulation Of Interleukin-1-mediated Signaling Pathway
Interleukin-1, Type II, Blocking Receptor Activity
Positive Regulation Of Cytokine-mediated Signaling Pathway
Regulation Of Multicellular Organismal Process
Positive Regulation Of Interleukin-1 Production
Positive Regulation Of Response To Cytokine Stimulus
Regulation Of Macromolecule Metabolic Process
Regulation Of Canonical NF-kappaB Signal Transduction
AIM2 Inflammasome Complex Assembly
Protease Inhibitor Complex
Interleukin-1, Type I, Activating Receptor Activity
Interleukin-33 Receptor Activity
Regulation Of Cytokine Production Involved In Inflammatory Response
Negative Regulation Of Interleukin-1 Alpha Production
Entry Of Viral Genome Into Host Nucleus Through Nuclear Pore Complex Via Importin
AIM2 Inflammasome Complex
IPAF Inflammasome Complex
Calpain Complex
Viral Penetration Into Host Nucleus
Mammary Gland Involution
Cysteine-type Peptidase Activity
Cytokine Precursor Processing
Positive Regulation Of Neutrophil Extravasation
Somite Specification
Granulocyte Colony-stimulating Factor Signaling Pathway
NMDA Selective Glutamate Receptor Signaling Pathway
Osmosensory Signaling Pathway
NLRP3 Inflammasome Complex
Response To Peptide
Organelle Organization
Regulation Of Programmed Cell Death
Response To Alcohol
Regulation Of Organelle Organization
Regulation Of Apoptotic Process
Identical Protein Binding
Positive Regulation Of Organelle Organization
Regulation Of Multicellular Organismal Process
Protease Binding
Cytoplasm
Regulation Of Signal Transduction
Regulation Of Cellular Component Organization
Developmental Process
Regulation Of Cell Communication
Regulation Of Signaling
Cellular Response To Amino Acid Stimulus
Positive Regulation Of Gene Expression
Response To Lipid
Positive Regulation Of Programmed Cell Death
Negative Regulation Of MiRNA-mediated Gene Silencing
Negative Regulation Of Post-transcriptional Gene Silencing By Regulatory NcRNA
Negative Regulation Of Gene Expression
Regulation Of Intracellular Signal Transduction
Hepatocyte Apoptotic Process
Cytosol
Regulation Of Actin Filament Depolymerization
Negative Regulation Of Apoptotic Process
Cell Junction Maintenance
Regulation Of Renin Secretion Into Blood Stream
Regulation Of Autophagy
Sarcomere
Negative Regulation Of Programmed Cell Death
Regulation Of Actin Filament-based Process
Regulation Of Mitochondrial Membrane Permeability
G-protein Beta-subunit Binding
Regulation Of Protein Localization
Response To Amino Acid
Release Of Cytochrome C From Mitochondria
Negative Regulation Of Macromolecule Metabolic Process
Negative Regulation Of Metabolic Process
Positive Regulation Of Signal Transduction
Response To Fluoride
Regulation Of Protein-containing Complex Disassembly
Positive Regulation Of Apoptotic Process
Cellular Component Maintenance
Regulation Of Membrane Permeability
Cysteine-type Peptidase Activity
Positive Regulation Of Cellular Component Organization
Regulation Of MiRNA-mediated Gene Silencing
Negative Regulation Of Protein Localization
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