CLTCL1 and CDC73

Number of citations of the paper that reports this interaction (PubMedID 18687124)
42

Data Source:
BioGRID (two hybrid)

		CLTCL1	CDC73
Description		clathrin heavy chain like 1	cell division cycle 73
Image		No pdb structure
GO Annotations	Cellular Component	Early Endosome Late Endosome Trans-Golgi Network Spindle Cytosol Plasma Membrane Clathrin-coated Pit Membrane Clathrin Coat Of Trans-Golgi Network Vesicle Coated Vesicle Clathrin-coated Vesicle Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle Clathrin-coated Endocytic Vesicle Recycling Endosome Extracellular Exosome Clathrin Complex Sorting Endosome	Chromosome, Telomeric Region Nucleus Nucleoplasm Cytosol Cdc73/Paf1 Complex
	Molecular Function	Structural Molecule Activity Protein Binding Clathrin Light Chain Binding	RNA Polymerase II Complex Binding Protein Binding
	Biological Process	Mitotic Cell Cycle Intracellular Protein Transport Receptor-mediated Endocytosis Anatomical Structure Morphogenesis Vesicle-mediated Transport Retrograde Transport, Endosome To Golgi Positive Regulation Of D-glucose Import	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Cell Growth Endodermal Cell Fate Commitment Regulation Of Transcription By RNA Polymerase II Transcription Elongation By RNA Polymerase II Negative Regulation Of Cell Population Proliferation Wnt Signaling Pathway Stem Cell Population Maintenance Positive Regulation Of Wnt Signaling Pathway MRNA 3'-end Processing Positive Regulation Of MRNA 3'-end Processing Protein Destabilization Positive Regulation Of Transcription Elongation By RNA Polymerase II Negative Regulation Of Apoptotic Process Negative Regulation Of Myeloid Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Fibroblast Proliferation Negative Regulation Of Epithelial Cell Proliferation Cellular Response To Lipopolysaccharide Positive Regulation Of Cell Cycle G1/S Phase Transition Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways		Gap junction degradation Formation of annular gap junctions EPH-ephrin mediated repulsion of cells Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis	Formation of RNA Pol II elongation complex Formation of the beta-catenin:TCF transactivating complex Hedgehog 'on' state RNA Polymerase II Pre-transcription Events RNA Polymerase II Transcription Elongation E3 ubiquitin ligases ubiquitinate target proteins
Drugs
Diseases			Primary hyperparathyroidism; Familial hyperparathyroidism (HRPT)
GWAS		Cognitive decline rate in late mild cognitive impairment ( 26252872) Metabolite levels ( 22916037)	Chronotype ( 30696823) High density lipoprotein cholesterol levels ( 34074324) Ovarian disease with few adhesions ( 28333195) Photic sneeze reflex ( 27182965) Subcutaneous adipose tissue ( 22589738) Takayasu arteritis ( 25604533) White matter hyperintensity burden ( 25663218)
Interacting Genes		5 interacting genes: CDC73 EGFR PICALM SNCA SNX5	45 interacting genes: ALAS1 ANXA6 CEP70 CLTCL1 CTNNB1 DDAH2 DES DMPK EEA1 FAF1 FHL2 FSD2 GC GOLGA2 GOLGA6L9 H1-2 HAP1 HSF2BP HSPA4 ITFG1 KASH5 KCNH2 KIAA1549 KIDINS220 MCM3AP MTUS2 MYC PICK1 PITHD1 PTPN11 RABEP1 RNF20 RNF40 TCEA1 TCF4 TFCP2 TOMM20 TRIM23 TSGA10 USP12 USP15 USP25 USP28 VPS37B WWC1
Entrez ID		8218	79577
HPRD ID		03172	09581
Ensembl ID		ENSG00000070371	ENSG00000134371
Uniprot IDs		A0A087WX41 P53675	Q6P1J9
PDB IDs			5YDE 5YDF 6TED 7OOP 7OPC 7OPD 7UNC 7UND 8A3Y 9EGX 9EGY 9EGZ 9EH0 9EH2
Enriched GO Terms of Interacting Partners?		Regulation Of Protein Localization To Cell Periphery Positive Regulation Of Cell Communication Perinuclear Region Of Cytoplasm Positive Regulation Of Signaling Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of ERBB Signaling Pathway Cadherin Binding Tau Protein Binding Positive Regulation Of Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Positive Regulation Of Cell Cycle G1/S Phase Transition Regulation Of Signal Transduction Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Protein Localization To Cell Periphery Regulation Of Fibroblast Proliferation Regulation Of RNA Biosynthetic Process Regulation Of ERBB Signaling Pathway Multivesicular Body, Internal Vesicle Lumen Response To Desipramine Negative Regulation Of Norepinephrine Uptake Regulation Of Amide Metabolic Process Phospholipase D Inhibitor Activity SNARE Binding Positive Regulation Of SNARE Complex Assembly Receptor Internalization Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Endocytosis Protein Destabilization Macropinocytic Cup Positive Regulation Of Metabolic Process Regulation Of Cell Communication Regulation Of RNA Metabolic Process Regulation Of Signaling Positive Regulation Of Signal Transduction Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Import Into Cell Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of Cell Cycle Phase Transition Negative Regulation Of Protein Catabolic Process Phospholipid Binding Shc-EGFR Complex Positive Regulation Of RNA Metabolic Process Regulation Of Norepinephrine Uptake Negative Regulation Of Mitochondrial Electron Transport, NADH To Ubiquinone Positive Regulation Of Hydrogen Peroxide Catabolic Process Epidermal Growth Factor Catabolic Process Synaptic Vesicle	Deubiquitinase Activity Ubiquitin Protein Ligase Binding Beta-catenin-TCF7L2 Complex Neurotrophin Signaling Pathway HULC Complex Cysteine-type Deubiquitinase Activity Identical Protein Binding Protein Deubiquitination Fascia Adherens Protein Modification By Small Protein Removal
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