CLTCL1 and PICALM

Number of citations of the paper that reports this interaction (PMID 10436022)
68

Data Source:
HPRD (in vivo, in vitro)

		CLTCL1	PICALM
Gene Name		clathrin, heavy chain-like 1	phosphatidylinositol binding clathrin assembly protein
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Trans-Golgi Network Spindle Coated Pit Membrane Clathrin Coat Of Trans-Golgi Network Vesicle Clathrin Coat Of Coated Pit Coated Vesicle Clathrin-coated Vesicle Extracellular Vesicular Exosome	Nucleus Golgi Apparatus Coated Pit Membrane AP-2 Adaptor Complex Clathrin Coat Of Coated Pit Vesicle Presynaptic Membrane Neuronal Cell Body Intracellular Membrane-bounded Organelle Postsynaptic Membrane Perinuclear Region Of Cytoplasm Neurofibrillary Tangle
	Molecular Function	Signal Transducer Activity Structural Molecule Activity Protein Binding	Protein Binding 1-phosphatidylinositol Binding Clathrin Binding Clathrin Heavy Chain Binding Clathrin Adaptor Activity
	Biological Process	Intracellular Protein Transport Receptor-mediated Endocytosis Mitotic Nuclear Division Signal Transduction Anatomical Structure Morphogenesis Positive Regulation Of Glucose Import	Protein Complex Assembly Receptor-mediated Endocytosis Axonogenesis Cell Proliferation Negative Regulation Of Gene Expression Synaptic Vesicle Maturation Vesicle-mediated Transport Endosomal Transport Hemopoiesis Regulation Of Endocytosis Receptor Internalization Regulation Of Protein Localization Cargo Loading Into Vesicle Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Receptor-mediated Endocytosis Clathrin Coat Assembly Dendrite Morphogenesis Iron Ion Homeostasis Clathrin-mediated Endocytosis Iron Ion Import Into Cell Positive Regulation Of Neuron Death Positive Regulation Of Beta-amyloid Formation Regulation Of Aspartic-type Endopeptidase Activity Involved In Amyloid Precursor Protein Catabolic Process Positive Regulation Of Aspartic-type Endopeptidase Activity Involved In Amyloid Precursor Protein Catabolic Process Negative Regulation Of Metalloendopeptidase Activity Involved In Amyloid Precursor Protein Catabolic Process
Pathways		Formation of annular gap junctions EPH-ephrin mediated repulsion of cells Axon guidance Gap junction degradation Gap junction trafficking and regulation Gap junction trafficking EPH-Ephrin signaling	Golgi Associated Vesicle Biogenesis trans-Golgi Network Vesicle Budding Clathrin derived vesicle budding
Drugs
Diseases
GWAS		Metabolite levels ( 22916037)	Alzheimer's disease ( 22832961 19734902 21627779) Alzheimer's disease (late onset) ( 21460841) Tourette syndrome ( 22889924)
Protein-Protein Interactions		3 interactors: EGFR PICALM SNX5	10 interactors: AP2A1 CASP3 CASP8 CLTC CLTCL1 DDIT3 EHD2 ITSN1 PELI2 PLCG1
Entrez ID		8218	8301
HPRD ID		03172	04320
Ensembl ID		ENSG00000070371	ENSG00000073921
Uniprot IDs		P53675	Q13492
PDB IDs
Enriched GO Terms of Interacting Partners?		Alkanesulfonate Metabolic Process Positive Regulation Of Aspartic-type Endopeptidase Activity Involved In Amyloid Precursor Protein Catabolic Process Vesicle Organization Endosomal Transport Activation Of Phospholipase A2 Activity By Calcium-mediated Signaling Astrocyte Activation Activation Of Phospholipase A2 Activity Regulation Of Aspartic-type Endopeptidase Activity Involved In Amyloid Precursor Protein Catabolic Process Negative Regulation Of Metalloendopeptidase Activity Involved In Amyloid Precursor Protein Catabolic Process Positive Regulation Of Phospholipase A2 Activity Response To Cobalamin Response To UV-A Cargo Loading Into Vesicle Iron Ion Import Into Cell Response To Hydroxyisoflavone Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Involved In G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Superoxide Anion Generation Cellular Localization Metal Ion Homeostasis Positive Regulation Of Catenin Import Into Nucleus Synaptic Vesicle Maturation Positive Regulation Of Beta-amyloid Formation Regulation Of Phospholipase A2 Activity Negative Regulation Of Amyloid Precursor Protein Catabolic Process Axonogenesis Regulation Of Superoxide Anion Generation Pinocytosis Ion Homeostasis Axon Development Iron Ion Import Cell Morphogenesis Involved In Neuron Differentiation Magnesium Ion Homeostasis Neuron Projection Morphogenesis Endocytosis Cellular Response To Estradiol Stimulus Regulation Of Beta-amyloid Formation Negative Regulation Of Receptor-mediated Endocytosis Protein Insertion Into Membrane Astrocyte Development Regulation Of Amyloid Precursor Protein Catabolic Process Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Positive Regulation Of Synaptic Transmission, Glutamatergic Cell Morphogenesis Involved In Differentiation Cell Proliferation Regulation Of Catenin Import Into Nucleus Cellular Response To Epidermal Growth Factor Stimulus Regulation Of Protein Localization Clathrin Coat Assembly Response To Epidermal Growth Factor Neuron Projection Development	Endocytosis Negative Regulation Of Hyaluronan Biosynthetic Process Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Vesicle-mediated Transport Apoptotic Signaling Pathway Positive Regulation Of Hydrolase Activity Cellular Response To Organic Substance Positive Regulation Of Cellular Protein Metabolic Process Establishment Of Localization In Cell Intrinsic Apoptotic Signaling Pathway Cell Surface Receptor Signaling Pathway Cellular Response To Growth Factor Stimulus Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Protein Metabolic Process Response To Growth Factor Positive Regulation Of Cell Death Immune System Process Regulation Of Immune System Process Regulation Of Phosphorylation Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of Neuron Apoptotic Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Intracellular Transport Cell Morphogenesis Involved In Differentiation Cellular Localization Anatomical Structure Morphogenesis Signal Transduction Positive Regulation Of Transport Regulation Of Phosphorus Metabolic Process Regulation Of Neuron Death Intracellular Transport Response To Organic Substance Positive Regulation Of Catalytic Activity Positive Regulation Of Cellular Metabolic Process Developmental Process Positive Regulation Of Intracellular Signal Transduction Signaling Positive Regulation Of Neuron Apoptotic Process Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Positive Regulation Of Phosphorylation Cell Communication Regulation Of Signal Transduction Enzyme Linked Receptor Protein Signaling Pathway Intracellular Protein Transport Receptor-mediated Endocytosis Execution Phase Of Apoptosis Positive Regulation Of Neuron Death Negative Regulation Of Determination Of Dorsal Identity
Tagcloud ?			abeta1 accelerated amyloid apoe4 bace1 becomes casp3 deposits event hallmark hyperphosphorylation increasingly later losses nonetheless nonsynonymous nontransgenic oxys posits precede proof psen1 psen2 snps sorl1 sporadic triggers turn unlikely
Tagcloud (Difference) ?			abeta1 accelerated amyloid apoe4 bace1 becomes casp3 deposits event hallmark hyperphosphorylation increasingly later losses nonetheless nonsynonymous nontransgenic oxys posits precede proof psen1 psen2 snps sorl1 sporadic triggers turn unlikely
Tagcloud (Intersection) ?