EDEM1 and PDZD11

		EDEM1	PDZD11
Description		ER degradation enhancing alpha-mannosidase like protein 1	PDZ domain containing 11
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Aggresome Endoplasmic Reticulum Quality Control Compartment	Extracellular Region Cytoplasm Cytosol Plasma Membrane Cell-cell Junction Adherens Junction Membrane Basolateral Plasma Membrane Pore Complex Anchoring Junction Presynapse
	Molecular Function	Mannosyl-oligosaccharide 1,2-alpha-mannosidase Activity Calcium Ion Binding Protein Binding Misfolded Protein Binding	Protein Binding Protein-macromolecule Adaptor Activity
	Biological Process	Carbohydrate Metabolic Process Ubiquitin-dependent Protein Catabolic Process Response To Unfolded Protein Glycoprotein Metabolic Process ERAD Pathway Protein Targeting To ER Positive Regulation Of Retrograde Protein Transport, ER To Cytosol Endoplasmic Reticulum Mannose Trimming	Neurotransmitter Secretion Regulation Of Synaptic Assembly At Neuromuscular Junction Pore Complex Assembly Synaptic Vesicle Transport
Pathways		XBP1(S) activates chaperone genes ER Quality Control Compartment (ERQC)	Biotin transport and metabolism Vitamin B5 (pantothenate) metabolism Transport of vitamins, nucleosides, and related molecules Ion influx/efflux at host-pathogen interface Ion transport by P-type ATPases
Drugs
Diseases
GWAS		Alzheimer's disease ( 33074286) Diverticular disease ( 30177863) Liver enzyme levels (alkaline phosphatase) ( 33972514) Metabolite levels ( 23823483) Smoking initiation (ever regular vs never regular) ( 30679032) Smoking status (ever vs never smokers) ( 30643258) Uterine fibroids ( 28836065)
Interacting Genes		1 interacting genes: CANX	4 interacting genes: ATP2B2 ATP7A MAGI2 SIGMAR1
Entrez ID		9695	51248
HPRD ID		09644	06622
Ensembl ID		ENSG00000134109	ENSG00000120509
Uniprot IDs		Q92611	Q5EBL8
PDB IDs
Enriched GO Terms of Interacting Partners?		Mitochondria-associated Endoplasmic Reticulum Membrane Contact Site Melanosome Membrane Secretion By Cell Protein Folding In Endoplasmic Reticulum Secretion Presynapse Positive Regulation Of Lymphocyte Activation Nucleosome Disassembly BBAF Complex Brahma Complex NBAF Complex Protein-DNA Complex Disassembly Regulation Of Lymphocyte Activation NpBAF Complex Positive Regulation Of Cell Activation Regulation Of Fatty Acid Beta-oxidation Phosphatidylinositol 3-kinase Binding Negative Regulation Of B Cell Apoptotic Process Protein-macromolecule Adaptor Activity Type B Pancreatic Cell Proliferation Positive Regulation Of Glycogen Biosynthetic Process Positive Regulation Of Fatty Acid Beta-oxidation Regulation Of Type B Pancreatic Cell Proliferation Negative Regulation Of Fatty Acid Transport Regulation Of Long-chain Fatty Acid Import Into Cell Phosphatidylinositol 3-kinase Activator Activity Insulin Receptor Binding Negative Regulation Of Long-chain Fatty Acid Import Across Plasma Membrane Regulation Of B Cell Apoptotic Process Positive Regulation Of Type B Pancreatic Cell Proliferation Positive Regulation Of Fatty Acid Oxidation Response To Endothelin Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Cellular Response To Endothelin Pore Complex Regulation Of Synaptic Assembly At Neuromuscular Junction Pore Complex Assembly
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