EDEM1

Gene Name		ER degradation enhancer, mannosidase alpha-like 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Endoplasmic Reticulum Membrane Integral Component Of Endoplasmic Reticulum Membrane
	Molecular Function	Mannosyl-oligosaccharide 1,2-alpha-mannosidase Activity Calcium Ion Binding Protein Binding Misfolded Protein Binding
	Biological Process	Protein Folding Activation Of Signaling Protein Activity Involved In Unfolded Protein Response Protein N-linked Glycosylation Via Asparagine ER-associated Ubiquitin-dependent Protein Catabolic Process Endoplasmic Reticulum Unfolded Protein Response Post-translational Protein Modification Cellular Protein Metabolic Process
Pathways		Diseases of glycosylation Defective ALG14 causes congenital myasthenic syndrome (ALG14-CMS) Defective MGAT2 causes MGAT2-CDG (CDG-2a) Defective ALG1 causes ALG1-CDG (CDG-1k) XBP1(S) activates chaperone genes Defective MOGS causes MOGS-CDG (CDG-2b) IRE1alpha activates chaperones Defective ALG9 causes ALG9-CDG (CDG-1l) Defective MAN1B1 causes MRT15 N-glycan trimming in the ER and Calnexin/Calreticulin cycle Unfolded Protein Response (UPR) Defective ALG11 causes ALG11-CDG (CDG-1p) Defective ALG2 causes ALG2-CDG (CDG-1i) Defective ALG3 causes ALG3-CDG (CDG-1d) Post-translational protein modification Defective DPAGT1 causes DPAGT1-CDG (CDG-1j) and CMSTA2 Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) Defective RFT1 causes RFT1-CDG (CDG-1n) Defective ALG6 causes ALG6-CDG (CDG-1c) Asparagine N-linked glycosylation Defective ALG8 causes ALG8-CDG (CDG-1h) Defective MPDU1 causes MPDU1-CDG (CDG-1f) Defective ALG12 causes ALG12-CDG (CDG-1g) ER Quality Control Compartment (ERQC) Diseases associated with N-glycosylation of proteins Calnexin/calreticulin cycle
Drugs
Diseases
GWAS
Protein-protein Interactions		1 interactors: CANX
Entrez ID		9695
HPRD ID		09644
Ensembl ID		ENSG00000134109
Uniprot IDs		Q92611
PDB IDs
Enriched GO Terms of Interacting Partners?		Synaptic Vesicle Endocytosis Synaptic Vesicle Recycling Clathrin-mediated Endocytosis Chaperone-mediated Protein Folding Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Protein N-linked Glycosylation Via Asparagine Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Synaptic Vesicle Transport Protein N-linked Glycosylation Protein Secretion Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Establishment Of Vesicle Localization Post-translational Protein Modification Vesicle Localization Antigen Processing And Presentation Of Peptide Antigen Protein Folding Antigen Processing And Presentation Aging Establishment Of Organelle Localization Macromolecule Glycosylation Protein Glycosylation Glycosylation Receptor-mediated Endocytosis Glycoprotein Biosynthetic Process Organelle Localization Glycoprotein Metabolic Process Secretion By Cell
Tagcloud ?		b27 carboxy chase coenzyme conformers derlin derlins dimer dimeric dimers disposal dispose erad hairpin histocompatibility hla hrd1 hydroxymethylglutaryl mannosidase misfolded monomeric pharamacologic predispose reductase sv5 tagged terminally upr xbp