CD3D and CD8B

Number of citations of the paper that reports this interaction (PMID 12215456)
24

Data Source:
HPRD (in vivo)

		CD3D	CD8B
Gene Name		CD3d molecule, delta (CD3-TCR complex)	CD8b molecule
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Plasma Membrane Integral Component Of Membrane T Cell Receptor Complex Alpha-beta T Cell Receptor Complex	Extracellular Region Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Early Endosome Membrane T Cell Receptor Complex
	Molecular Function	Transcription Coactivator Activity Transmembrane Signaling Receptor Activity Protein Heterodimerization Activity	Protein Binding Coreceptor Activity MHC Class I Protein Binding
	Biological Process	Cell Surface Receptor Signaling Pathway T Cell Differentiation T Cell Costimulation Positive Thymic T Cell Selection Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Immune Response T Cell Receptor Signaling Pathway	Immune Response Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Viral Process T Cell Activation Regulation Of Defense Response To Virus By Virus Regulation Of Immune Response
Pathways		TCR signaling Downstream TCR signaling Generation of second messenger molecules Translocation of ZAP-70 to Immunological synapse Costimulation by the CD28 family PD-1 signaling Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Phosphorylation of CD3 and TCR zeta chains Adaptive Immune System	Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters HIV Infection Host Interactions of HIV factors Nef Mediated CD8 Down-regulation The role of Nef in HIV-1 replication and disease pathogenesis Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Adaptive Immune System
Drugs
Diseases
GWAS			Progressive supranuclear palsy ( 21685912)
Protein-Protein Interactions		11 interactors: AP2M1 CANX CD247 CD3E CD3G CD8A CD8B HERPUD1 KCNA3 TRA TRB	3 interactors: CD3D CD8A ST3GAL4
Entrez ID		915	926
HPRD ID		01730	01725
Ensembl ID		ENSG00000167286	ENSG00000172116
Uniprot IDs		B0YIY4 P04234	P10966
PDB IDs		1XIW
Enriched GO Terms of Interacting Partners?		Regulation Of Defense Response To Virus By Virus Immune System Process Regulation Of Immune System Process T Cell Aggregation T Cell Activation Lymphocyte Aggregation Leukocyte Aggregation Signaling T Cell Costimulation Cell Communication Regulation Of Defense Response To Virus Leukocyte Cell-cell Adhesion Homotypic Cell-cell Adhesion Regulation Of Immune Response T Cell Receptor Signaling Pathway Lymphocyte Activation Antigen Receptor-mediated Signaling Pathway Leukocyte Activation Single Organismal Cell-cell Adhesion Positive Regulation Of Calcium-mediated Signaling Positive Regulation Of T Cell Activation Positive Regulation Of Homotypic Cell-cell Adhesion Endocytosis Clathrin-mediated Endocytosis Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cell Activation Positive Regulation Of Cell-cell Adhesion Regulation Of Calcium-mediated Signaling Immune Response-activating Cell Surface Receptor Signaling Pathway Antigen Processing And Presentation Regulation Of T Cell Activation Positive Regulation Of Cell Activation Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Cell-cell Adhesion Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell Adhesion Cell Surface Receptor Signaling Pathway Regulation Of Lymphocyte Activation Cytotoxic T Cell Differentiation Positive Regulation Of ER-associated Ubiquitin-dependent Protein Catabolic Process Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Immune Response-regulating Signaling Pathway Regulation Of Cell Activation Signal Transduction Cell Adhesion Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Immune Response Viral Process Synaptic Transmission	Cytotoxic T Cell Differentiation T Cell Differentiation Lymphocyte Differentiation T Cell Aggregation T Cell Activation Lymphocyte Aggregation Leukocyte Aggregation Leukocyte Cell-cell Adhesion Homotypic Cell-cell Adhesion Leukocyte Differentiation Lymphocyte Activation Positive Thymic T Cell Selection Leukocyte Activation Single Organismal Cell-cell Adhesion Hemopoiesis Cell Activation Immune System Development Thymic T Cell Selection Keratan Sulfate Biosynthetic Process Positive T Cell Selection Positive Regulation Of Calcium-mediated Signaling Keratan Sulfate Metabolic Process Regulation Of Immune Response T Cell Mediated Immunity T Cell Selection Regulation Of Calcium-mediated Signaling O-glycan Processing Sialylation Dolichol-linked Oligosaccharide Biosynthetic Process Cell Adhesion T Cell Differentiation In Thymus Regulation Of Immune System Process T Cell Costimulation Protein O-linked Glycosylation Glycosaminoglycan Biosynthetic Process Protein N-linked Glycosylation Via Asparagine
Tagcloud ?		aurkb bub1b ccnb1 cd247 cd3g cd8a cdc20 cdca8 cenpa cytoscape dihydroxyfluorane epstain generank hindering itgb5 itk kif2c lcp2 limma lymphoblasts mad2l1 nup37 pik3r3 plcg2 prkcq rpa3 softwares vav3 zap70
Tagcloud (Difference) ?		aurkb bub1b ccnb1 cd247 cd3g cd8a cdc20 cdca8 cenpa cytoscape dihydroxyfluorane epstain generank hindering itgb5 itk kif2c lcp2 limma lymphoblasts mad2l1 nup37 pik3r3 plcg2 prkcq rpa3 softwares vav3 zap70
Tagcloud (Intersection) ?