CD3D and AP2M1

Number of citations of the paper that reports this interaction (PubMedID 15778375)
0

Data Source:
HPRD (two hybrid, in vitro)

		CD3D	AP2M1
Description		CD3 delta subunit of T-cell receptor complex	adaptor related protein complex 2 subunit mu 1
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GO Annotations	Cellular Component	Cytoplasm Plasma Membrane External Side Of Plasma Membrane Membrane Clathrin-coated Endocytic Vesicle Membrane T Cell Receptor Complex Alpha-beta T Cell Receptor Complex	Lysosomal Membrane Cytosol Plasma Membrane Clathrin-coated Pit Synaptic Vesicle Cytoplasmic Side Of Plasma Membrane Membrane AP-2 Adaptor Complex Clathrin Adaptor Complex Endocytic Vesicle Membrane Clathrin-coated Endocytic Vesicle Membrane Cytoplasmic Vesicle Endolysosome Membrane Synapse Clathrin-coated Endocytic Vesicle Extracellular Exosome Postsynapse Extrinsic Component Of Presynaptic Endocytic Zone Membrane Glutamatergic Synapse
	Molecular Function	Transmembrane Signaling Receptor Activity Protein Binding Identical Protein Binding	Signal Sequence Binding Protein Binding Lipid Binding Clathrin Adaptor Activity Transmembrane Transporter Binding Low-density Lipoprotein Particle Receptor Binding Disordered Domain Specific Binding
	Biological Process	Adaptive Immune Response Immune System Process Cell Surface Receptor Signaling Pathway Positive Thymic T Cell Selection Alpha-beta T Cell Activation T Cell Receptor Signaling Pathway	Positive Regulation Of Receptor Internalization Intracellular Protein Transport Endocytosis Vesicle Budding From Membrane Protein Transport Vesicle-mediated Transport Receptor Internalization Synaptic Vesicle Endocytosis Protein-containing Complex Assembly Clathrin-dependent Endocytosis Regulation Of Vesicle Size Postsynaptic Neurotransmitter Receptor Internalization Vesicle-mediated Transport In Synapse Positive Regulation Of Synaptic Vesicle Endocytosis Negative Regulation Of Protein Localization To Plasma Membrane
Pathways		Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Downstream TCR signaling Phosphorylation of CD3 and TCR zeta chains Translocation of ZAP-70 to Immunological synapse Generation of second messenger molecules Co-inhibition by PD-1 Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis	Nef mediated downregulation of CD28 cell surface expression Nef Mediated CD4 Down-regulation Retrograde neurotrophin signalling Retrograde neurotrophin signalling Nef Mediated CD8 Down-regulation Gap junction degradation Formation of annular gap junctions MHC class II antigen presentation EPH-ephrin mediated repulsion of cells Recycling pathway of L1 Recycling pathway of L1 WNT5A-dependent internalization of FZD4 WNT5A-dependent internalization of FZD2, FZD5 and ROR2 Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis VLDLR internalisation and degradation LDL clearance Potential therapeutics for SARS
Drugs		Muromonab Blinatumomab Teclistamab Odronextamab
Diseases		T-B+Severe combined immunodeficiencies (SCIDs), including the following eight diseases: X-linked SCID; Janus kinase-3 (Jak3) deficiency; IL-7 receptor alpha (IL7R alpha) deficiency; IL-2 receptor alpha (IL2R alpha) deficiency; CD45 deficiency; CD3 deficiency; Winged Helix Nude (WHN) deficiency; Immunodeficiency with thynoma
GWAS		Pulse pressure ( 27841878)	Major depressive disorder ( 22472876)
Interacting Genes		12 interacting genes: AP2M1 CANX CD247 CD3E CD3G CD8A CD8B HERPUD1 KCNA3 SGTB TRA TRB	86 interacting genes: ADRA1B AGTR1 AP2B1 AQP4 ARRB2 ATG9A ATXN1L BDKRB2 C1orf35 CACNA1A CD22 CD2BP2 CD3D CDK11B CEBPA CLK2 CORO7 CSNK2B CTLA4 CXorf51A CXorf51B DAB2 DCX DPPA2 DVL2 EAF1 EHD2 EIF1AD FAM90A1 FURIN FXR2 GAK GRIN2A GRIN2B H2BC10 H2BC13 H2BC21 H2BC4 H2BC6 H2BC7 H2BC8 HEXIM2 HOOK2 HTR6 IKZF1 IRS2 KCNJ11 KNOP1 LAMP1 LTB4R2 LUC7L2 LY9 MAB21L3 MED4 MEGF10 MFAP1 MPP1 MTURN NAA11 NCOR2 NDRG1 NKAPD1 PRPF18 PRPF38A PRR13 PTS RALBP1 RNF111 RPL22 RPL38 RRP12 RSPH14 RUNDC3A SFRP4 SNCA SPATS2 STON2 SYNJ1 TASOR TBC1D5 TGOLN2 TIAM1 TMA16 UBC ZBTB8A ZNF581
Entrez ID		915	1173
HPRD ID		01730	03014
Ensembl ID		ENSG00000167286	ENSG00000161203
Uniprot IDs		B0YIY4 P04234	B4DNB9 E9PFW3 Q96CW1
PDB IDs		1XIW 6JXR 7FJD 7FJE 7FJF 7PHR 8ES7 8ES8 8ES9 8JC0 8JCB 8TW4 8TW6 8WXE 8WY0 8WYI 8YC0 9BBC 9C3E 9CI8 9CIA 9CQ4	1H6E 6BNT 6URI
Enriched GO Terms of Interacting Partners?		Alpha-beta T Cell Receptor Complex T Cell Receptor Complex Gamma-delta T Cell Receptor Complex Adaptive Immune Response T Cell Receptor Signaling Pathway Antigen Receptor-mediated Signaling Pathway Gamma-delta T Cell Activation Immune Response-activating Cell Surface Receptor Signaling Pathway Detection Of Tumor Cell Immune Response-regulating Cell Surface Receptor Signaling Pathway T Cell Activation T Cell Mediated Cytotoxicity Directed Against Tumor Cell Target T Cell Mediated Immunity Immune Response-activating Signaling Pathway Immune Response Immune Response-regulating Signaling Pathway Activation Of Immune Response Lymphocyte Activation Immune Response To Tumor Cell Membrane Leukocyte Activation Positive Thymic T Cell Selection T Cell Receptor Binding Alpha-beta T Cell Activation Positive T Cell Selection Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Cell Activation Positive Regulation Of Immune Response Lymphocyte Mediated Immunity MHC Class I Protein Binding T Cell Mediated Cytotoxicity Immune System Process Thymic T Cell Selection Protein-containing Complex Assembly Endoplasmic Reticulum Quality Control Compartment Leukocyte Mediated Immunity Protein-containing Complex Organization T Cell Selection Protein Targeting To ER Clathrin-dependent Endocytosis Detection Of Biotic Stimulus Signaling Receptor Complex Adaptor Activity Establishment Of Protein Localization To Endoplasmic Reticulum Regulation Of Immune Response Synaptic Vesicle Endocytosis Positive Regulation Of Immune System Process Presynaptic Endocytosis Transmembrane Signaling Receptor Activity Plasma Membrane Protein Complex Oligomerization	Innate Immune Response In Mucosa Mucosal Immune Response Organ Or Tissue Specific Immune Response Protein-containing Complex Organization Protein-containing Complex Assembly Protein Heterodimerization Activity Structural Constituent Of Chromatin Antibacterial Humoral Response Nucleosome Assembly Protein Domain Specific Binding Nucleosome Nucleosome Organization Protein-DNA Complex Assembly AP-2 Adaptor Complex Import Into Cell Endocytosis Receptor-mediated Endocytosis Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Defense Response To Gram-positive Bacterium Synaptic Vesicle Endocytosis Synaptic Vesicle Uncoating Presynaptic Endocytosis Trans-synaptic Signaling Clathrin Adaptor Activity Synaptic Signaling Clathrin Coat Assembly Nucleoplasm Positive Regulation Of Receptor-mediated Endocytosis Clathrin-coated Endocytic Vesicle Antimicrobial Humoral Response Positive Regulation Of Endocytosis Clathrin Coat Disassembly Regulation Of Neuronal Synaptic Plasticity Regulation Of Endocytosis Chemical Synaptic Transmission Excitatory Postsynaptic Potential Regulation Of Presynapse Assembly Regulation Of Presynapse Organization Vesicle Uncoating Nucleus Positive Regulation Of Receptor Internalization Synaptic Membrane Protein Binding Cellular Component Assembly NMDA Glutamate Receptor Activity Synapse Clathrin-dependent Endocytosis Synaptic Vesicle Regulation Of Vesicle-mediated Transport NMDA Selective Glutamate Receptor Complex
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