CD1D and PTPRC

Number of citations of the paper that reports this interaction (PMID 10473580)
4

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		CD1D	PTPRC
Gene Name		CD1d molecule	protein tyrosine phosphatase, receptor type, C
Image
Gene Ontology Annotations	Cellular Component	Cytoplasm Lysosomal Membrane Integral Component Of Plasma Membrane Cell Surface Endosome Membrane	Plasma Membrane Integral Component Of Plasma Membrane Focal Adhesion External Side Of Plasma Membrane Membrane Membrane Raft Extracellular Vesicular Exosome
	Molecular Function	Receptor Activity Beta-2-microglobulin Binding Lipid Antigen Binding Endogenous Lipid Antigen Binding Exogenous Lipid Antigen Binding Histone Binding Cell Adhesion Molecule Binding Lipopeptide Binding	Protein Tyrosine Phosphatase Activity Transmembrane Receptor Protein Tyrosine Phosphatase Activity Protein Binding Protein Kinase Binding
	Biological Process	Viral Process Detection Of Bacterium Heterotypic Cell-cell Adhesion Positive Regulation Of T Cell Proliferation T Cell Selection Innate Immune Response Positive Regulation Of Innate Immune Response Antigen Processing And Presentation, Endogenous Lipid Antigen Via MHC Class Ib Antigen Processing And Presentation, Exogenous Lipid Antigen Via MHC Class Ib	Negative Regulation Of T Cell Mediated Cytotoxicity Negative Regulation Of Cytokine-mediated Signaling Pathway Hematopoietic Progenitor Cell Differentiation Immunoglobulin Biosynthetic Process Negative Regulation Of Protein Kinase Activity Protein Dephosphorylation Negative Regulation Of Cell Adhesion Involved In Substrate-bound Cell Migration Cell Surface Receptor Signaling Pathway Axon Guidance Dephosphorylation T Cell Differentiation Positive Regulation Of B Cell Proliferation Peptidyl-tyrosine Dephosphorylation B Cell Proliferation Positive Regulation Of T Cell Proliferation Cell Cycle Phase Transition Positive Regulation Of Protein Kinase Activity Bone Marrow Development Stem Cell Development T Cell Receptor Signaling Pathway B Cell Receptor Signaling Pathway Positive Regulation Of Antigen Receptor-mediated Signaling Pathway Release Of Sequestered Calcium Ion Into Cytosol Defense Response To Virus Regulation Of Cell Cycle Positive Regulation Of Hematopoietic Stem Cell Migration Positive Regulation Of Stem Cell Proliferation
Pathways			TCR signaling Axon guidance Semaphorin interactions Other semaphorin interactions Phosphorylation of CD3 and TCR zeta chains Adaptive Immune System
Drugs
Diseases
GWAS			Mean corpuscular hemoglobin ( 20139978)
Protein-Protein Interactions		7 interactors: B2M CALR CANX CD74 P4HB PTPRC TRB	43 interactors: ANP32A CD1D CD2 CD22 CD247 CD28 CD4 CD8A CSNK2A1 CSNK2A2 CXCR4 DPP4 EZR FCGR3A FYN GANAB GRB2 IFNAR1 INSR IRS1 ITGAL JAK1 JAK2 JAK3 LCK LCP2 LGALS1 LSM1 LYN MBL2 PAEP PPFIA1 PPFIBP2 PRKCSH PTPN6 PTPRCAP RASA1 RNF11 SEMA4D SKAP1 TYK2 UHRF2 ZAP70
Entrez ID		912	5788
HPRD ID		01780	01050
Ensembl ID		ENSG00000158473	ENSG00000081237
Uniprot IDs		P15813	M9MML4 P08575
PDB IDs		1ZT4 2PO6 3HUJ 3SDX 3TZV 3U0P 3VWJ 3VWK 4EN3 4LHU	1YGR 1YGU
Enriched GO Terms of Interacting Partners?		Protein Folding Antigen Processing And Presentation Of Peptide Antigen Chaperone-mediated Protein Folding Antigen Processing And Presentation T Cell Differentiation In Thymus Positive Thymic T Cell Selection Negative Thymic T Cell Selection Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I T Cell Differentiation Negative T Cell Selection Thymic T Cell Selection Positive T Cell Selection Lymphocyte Differentiation Positive Regulation Of Immune System Process T Cell Aggregation T Cell Activation Lymphocyte Aggregation Leukocyte Aggregation Immune System Process Positive Regulation Of B Cell Proliferation Cellular Protein Metabolic Process Leukocyte Cell-cell Adhesion T Cell Selection Homotypic Cell-cell Adhesion Leukocyte Differentiation Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Cellular Component Movement Positive Regulation Of Locomotion Positive Regulation Of Cell Adhesion Regulation Of B Cell Proliferation Lymphocyte Activation Positive Regulation Of Leukocyte Chemotaxis Regulation Of Immune System Process Positive Regulation Of B Cell Activation Positive Regulation Of Protein Kinase Activity Metal Ion Homeostasis Homeostatic Process Leukocyte Activation Positive Regulation Of Kinase Activity Protein Metabolic Process Positive Regulation Of T Cell Mediated Cytotoxicity Positive Regulation Of T Cell Differentiation Regulation Of Apoptotic Process Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Positive Regulation Of Leukocyte Migration Single Organismal Cell-cell Adhesion Regulation Of T Cell Mediated Cytotoxicity Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Positive Regulation Of Lymphocyte Differentiation	Regulation Of Immune System Process Regulation Of Immune Response Positive Regulation Of Cell Activation Immune Response Immune System Process Defense Response Positive Regulation Of T Cell Activation Positive Regulation Of Homotypic Cell-cell Adhesion Innate Immune Response Regulation Of Cell-cell Adhesion Regulation Of T Cell Activation Positive Regulation Of Cell-cell Adhesion Regulation Of Cell Adhesion Peptidyl-tyrosine Autophosphorylation Cell Activation Positive Regulation Of Cell Adhesion Regulation Of Cell Activation Leukocyte Activation Regulation Of Lymphocyte Activation T Cell Costimulation Leukocyte Cell-cell Adhesion Positive Regulation Of Immune System Process Homotypic Cell-cell Adhesion Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Leukocyte Aggregation Locomotion Lymphocyte Activation Single Organismal Cell-cell Adhesion Cell Surface Receptor Signaling Pathway T Cell Aggregation T Cell Activation Lymphocyte Aggregation Antigen Receptor-mediated Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Signal Transduction Response To Stress Immune Response-regulating Signaling Pathway Signal Transduction Movement Of Cell Or Subcellular Component Positive Regulation Of Immune Response Cell Adhesion Signaling Response To Stimulus Regulation Of Signal Transduction Cell Communication T Cell Receptor Signaling Pathway Peptidyl-tyrosine Phosphorylation Positive Regulation Of Intracellular Signal Transduction
Tagcloud ?		arranged cd1a cd1b cd1c cd1e cloning code consist cosmid cosmids distant evenly exception histocompatibility linkage mhc microglobulin orientation overlapping pulse relatives serologically spaced spanned thymocyte tight walking wts	abl adaptor bcr cd45 chemistry cief cml combines crkl describes detect example focusing isoelectric limit linking lysate nanocapillary nanogram nl pg protocol ptyr207 quantities reproducible screen throughput tkis uv
Tagcloud (Difference) ?		arranged cd1a cd1b cd1c cd1e cloning code consist cosmid cosmids distant evenly exception histocompatibility linkage mhc microglobulin orientation overlapping pulse relatives serologically spaced spanned thymocyte tight walking wts	abl adaptor bcr cd45 chemistry cief cml combines crkl describes detect example focusing isoelectric limit linking lysate nanocapillary nanogram nl pg protocol ptyr207 quantities reproducible screen throughput tkis uv
Tagcloud (Intersection) ?