CD1D and CD74

Number of citations of the paper that reports this interaction (PMID 11754812)
48

Data Source:
HPRD (in vivo)

		CD1D	CD74
Gene Name		CD1d molecule	CD74 molecule, major histocompatibility complex, class II invariant chain
Image
Gene Ontology Annotations	Cellular Component	Cytoplasm Lysosomal Membrane Integral Component Of Plasma Membrane Cell Surface Endosome Membrane	Golgi Membrane Intracellular Lysosomal Membrane Multivesicular Body Vacuole Plasma Membrane External Side Of Plasma Membrane Cell Surface ER To Golgi Transport Vesicle Membrane Membrane Integral Component Of Membrane Transport Vesicle Membrane Endocytic Vesicle Membrane Clathrin-coated Endocytic Vesicle Membrane Trans-Golgi Network Membrane Macrophage Migration Inhibitory Factor Receptor Complex NOS2-CD74 Complex MHC Class II Protein Complex Lysosomal Lumen Extracellular Vesicular Exosome Integral Component Of Lumenal Side Of Endoplasmic Reticulum Membrane
	Molecular Function	Receptor Activity Beta-2-microglobulin Binding Lipid Antigen Binding Endogenous Lipid Antigen Binding Exogenous Lipid Antigen Binding Histone Binding Cell Adhesion Molecule Binding Lipopeptide Binding	Beta-amyloid Binding Cytokine Receptor Activity Protein Binding Cytokine Binding MHC Class II Protein Complex Binding Macrophage Migration Inhibitory Factor Binding MHC Class II Protein Binding MHC Class II Protein Binding, Via Antigen Binding Groove Identical Protein Binding Protein Binding Involved In Protein Folding Nitric-oxide Synthase Binding
	Biological Process	Viral Process Detection Of Bacterium Heterotypic Cell-cell Adhesion Positive Regulation Of T Cell Proliferation T Cell Selection Innate Immune Response Positive Regulation Of Innate Immune Response Antigen Processing And Presentation, Endogenous Lipid Antigen Via MHC Class Ib Antigen Processing And Presentation, Exogenous Lipid Antigen Via MHC Class Ib	Activation Of MAPK Activity Prostaglandin Biosynthetic Process Positive Regulation Of Cytokine-mediated Signaling Pathway Positive Regulation Of Dendritic Cell Antigen Processing And Presentation Negative Regulation Of Peptide Secretion Positive Regulation Of Type 2 Immune Response Negative Regulation Of Mature B Cell Apoptotic Process Protein Complex Assembly Intracellular Protein Transport Defense Response Signal Transduction Cell Proliferation Immunoglobulin Mediated Immune Response Antigen Processing And Presentation Of Endogenous Antigen Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Positive Regulation Of B Cell Proliferation Macrophage Migration Inhibitory Factor Signaling Pathway Regulation Of Macrophage Activation Negative Regulation Of Apoptotic Process Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator T Cell Selection Positive Thymic T Cell Selection Negative Thymic T Cell Selection Negative Regulation Of T Cell Differentiation Positive Regulation Of T Cell Differentiation Positive Regulation Of Fibroblast Proliferation Positive Regulation Of Peptidyl-tyrosine Phosphorylation Chaperone Mediated Protein Folding Requiring Cofactor Positive Regulation Of Macrophage Cytokine Production Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Neutrophil Chemotaxis Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Positive Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production
Pathways			MHC class II antigen presentation Adaptive Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		7 interactors: B2M CALR CANX CD74 P4HB PTPRC TRB	14 interactors: APP CD1D CD44 CTSF CTSL HADHA HLA-DMA HLA-DMB HLA-DPA1 HLA-DPB1 HLA-DQA1 HLA-DQB1 HLA-DRA MIF
Entrez ID		912	972
HPRD ID		01780	00825
Ensembl ID		ENSG00000158473	ENSG00000019582
Uniprot IDs		P15813	P04233
PDB IDs		1ZT4 2PO6 3HUJ 3SDX 3TZV 3U0P 3VWJ 3VWK 4EN3 4LHU	1A6A 1ICF 1IIE 1L3H 1MUJ 3PDO 3PGC 3PGD 3QXA 3QXD 4AEN 4AH2
Enriched GO Terms of Interacting Partners?		Protein Folding Antigen Processing And Presentation Of Peptide Antigen Chaperone-mediated Protein Folding Antigen Processing And Presentation T Cell Differentiation In Thymus Positive Thymic T Cell Selection Negative Thymic T Cell Selection Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I T Cell Differentiation Negative T Cell Selection Thymic T Cell Selection Positive T Cell Selection Lymphocyte Differentiation Positive Regulation Of Immune System Process T Cell Aggregation T Cell Activation Lymphocyte Aggregation Leukocyte Aggregation Immune System Process Positive Regulation Of B Cell Proliferation Cellular Protein Metabolic Process Leukocyte Cell-cell Adhesion T Cell Selection Homotypic Cell-cell Adhesion Leukocyte Differentiation Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Cellular Component Movement Positive Regulation Of Locomotion Positive Regulation Of Cell Adhesion Regulation Of B Cell Proliferation Lymphocyte Activation Positive Regulation Of Leukocyte Chemotaxis Regulation Of Immune System Process Positive Regulation Of B Cell Activation Positive Regulation Of Protein Kinase Activity Metal Ion Homeostasis Homeostatic Process Leukocyte Activation Positive Regulation Of Kinase Activity Protein Metabolic Process Positive Regulation Of T Cell Mediated Cytotoxicity Positive Regulation Of T Cell Differentiation Regulation Of Apoptotic Process Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Positive Regulation Of Leukocyte Migration Single Organismal Cell-cell Adhesion Regulation Of T Cell Mediated Cytotoxicity Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Positive Regulation Of Lymphocyte Differentiation	Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Antigen Processing And Presentation Positive Regulation Of Homotypic Cell-cell Adhesion Antigen Processing And Presentation Of Peptide Antigen Positive Regulation Of Cell-cell Adhesion Positive Regulation Of Cell Activation Immune Response Positive Regulation Of T Cell Activation Regulation Of Cell-cell Adhesion Positive Regulation Of Cell Adhesion Regulation Of Lymphocyte Activation Positive Regulation Of Immune Response Immune System Process Regulation Of Cell Activation Regulation Of T Cell Activation Innate Immune Response Regulation Of Immune Response Positive Regulation Of Immune System Process Regulation Of Cell Adhesion Interferon-gamma-mediated Signaling Pathway Cellular Response To Interferon-gamma Regulation Of Immune System Process Defense Response Response To Interferon-gamma T Cell Costimulation Peptide Antigen Assembly With MHC Class II Protein Complex MHC Class II Protein Complex Assembly T Cell Receptor Signaling Pathway Positive Regulation Of Lymphocyte Proliferation Positive Regulation Of Mononuclear Cell Proliferation Antigen Receptor-mediated Signaling Pathway Cytokine-mediated Signaling Pathway Immune Response-regulating Signaling Pathway Positive Regulation Of T Cell Proliferation Immune Response-activating Cell Surface Receptor Signaling Pathway Cellular Response To Cytokine Stimulus Regulation Of T Cell Proliferation Immune Response-regulating Cell Surface Receptor Signaling Pathway Response To Cytokine Response To Organic Substance Response To Stress Response To Stimulus Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Negative Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Cellular Response To Organic Substance Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Positive Regulation Of Cell Proliferation
Tagcloud ?		arranged cd1a cd1b cd1c cd1e cloning code consist cosmid cosmids distant evenly exception histocompatibility linkage mhc microglobulin orientation overlapping pulse relatives serologically spaced spanned thymocyte tight walking wts	actionable adenocarcinomas akt1 alk braf capture ccdc6 clip4 deemed driver fusions g719a genomic introns kif5b map2k1 nccn ngs nras pack pik3ca profiling rearranged ret ros1 socs5 targetable uniform v600e
Tagcloud (Difference) ?		arranged cd1a cd1b cd1c cd1e cloning code consist cosmid cosmids distant evenly exception histocompatibility linkage mhc microglobulin orientation overlapping pulse relatives serologically spaced spanned thymocyte tight walking wts	actionable adenocarcinomas akt1 alk braf capture ccdc6 clip4 deemed driver fusions g719a genomic introns kif5b map2k1 nccn ngs nras pack pik3ca profiling rearranged ret ros1 socs5 targetable uniform v600e
Tagcloud (Intersection) ?