SLC6A4 and YBX1

Number of citations of the paper that reports this interaction (PubMedID 15229244)
47

Data Source:
HPRD (two hybrid, in vitro, in vivo)

		SLC6A4	YBX1
Description		solute carrier family 6 member 4	Y-box binding protein 1
Image
GO Annotations	Cellular Component	Endosome Plasma Membrane Focal Adhesion Endosome Membrane Endomembrane System Membrane Presynaptic Membrane Cell Projection Neuron Projection Membrane Raft Synapse Postsynaptic Membrane Anchoring Junction Serotonergic Synapse	P-body Extracellular Region Nucleus Nucleoplasm U12-type Spliceosomal Complex Cytoplasm Endoplasmic Reticulum Cytosol Plasma Membrane Cytoplasmic Stress Granule Synapse Extracellular Exosome CRD-mediated MRNA Stability Complex Histone Pre-mRNA 3'end Processing Complex Ribonucleoprotein Complex
	Molecular Function	Integrin Binding Monoatomic Cation Channel Activity Neurotransmitter Transmembrane Transporter Activity Serotonin:sodium:chloride Symporter Activity Protein Binding Monoamine Transmembrane Transporter Activity Antiporter Activity Syntaxin-1 Binding Cocaine Binding Sodium Ion Binding Identical Protein Binding Metal Ion Binding Nitric-oxide Synthase Binding Actin Filament Binding Serotonin Binding	Nucleic Acid Binding DNA Binding Chromatin Binding Double-stranded DNA Binding Single-stranded DNA Binding RNA Binding MRNA Binding Protein Binding MiRNA Binding GTPase Binding C5-methylcytidine-containing RNA Reader Activity Sequence-specific Double-stranded DNA Binding
	Biological Process	Response To Hypoxia Neurotransmitter Transport Serotonin Transport Amino Acid Transport Response To Nutrient Memory Circadian Rhythm Response To Xenobiotic Stimulus Response To Toxic Substance Positive Regulation Of Gene Expression Positive Regulation Of Serotonin Secretion Monoamine Transport Negative Regulation Of Cerebellar Granule Cell Precursor Proliferation Negative Regulation Of Synaptic Transmission, Dopaminergic Response To Estradiol Sodium Ion Transmembrane Transport Vasoconstriction Negative Regulation Of Neuron Differentiation Positive Regulation Of Cell Cycle Negative Regulation Of Organ Growth Behavioral Response To Cocaine Enteric Nervous System Development Brain Morphogenesis Serotonin Uptake Membrane Depolarization Male Mating Behavior Platelet Aggregation Cellular Response To Retinoic Acid Cellular Response To CGMP Regulation Of Thalamus Size Neurotransmitter Reuptake Conditioned Place Preference	Negative Regulation Of Transcription By RNA Polymerase II In Utero Embryonic Development Regulation Of DNA-templated Transcription MRNA Processing RNA Splicing Epidermis Development Regulation Of Gene Expression Negative Regulation Of Translation Positive Regulation Of Transcription By RNA Polymerase II MRNA Stabilization Embryonic Morphogenesis RNA Transport TRNA Transport Negative Regulation Of Striated Muscle Cell Differentiation Positive Regulation Of Cell Division CRD-mediated MRNA Stabilization Cellular Response To Interleukin-7 Negative Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Protein Localization To Cytoplasmic Stress Granule MiRNA Transport Positive Regulation Of Cytoplasmic Translation Negative Regulation Of Cellular Senescence
Pathways		Serotonin clearance from the synaptic cleft SLC-mediated transport of neurotransmitters	SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription mRNA Splicing - Major Pathway mRNA Splicing - Minor Pathway Processing of Capped Intron-Containing Pre-mRNA Interferon gamma signaling Noncanonical activation of NOTCH3
Drugs		Fluvoxamine Amphetamine Phentermine Tramadol Citalopram Benzatropine Venlafaxine Atomoxetine Amitriptyline Protriptyline Loxapine Meperidine Imipramine Fluoxetine Duloxetine Dextromethorphan Nortriptyline Amoxapine Fenfluramine Mazindol Trazodone Verapamil Paroxetine Trimipramine Minaprine Pseudoephedrine Cocaine Cyclobenzaprine Dopamine Sertraline Sibutramine Chlorpheniramine Doxepin Nefazodone Desipramine Escitalopram Dexfenfluramine Aripiprazole Clomipramine Ephedra sinica root MMDA Midomafetamine 4-Methoxyamphetamine Metamfetamine Nomifensine Zimelidine Amineptine Bicifadine Milnacipran OPC-14523 CRx-119 Amitifadine Lumateperone Mianserin Tesofensine Tapentadol Vilazodone Desvenlafaxine Dexmethylphenidate Serotonin Levomilnacipran Butriptyline Vortioxetine Dosulepin Nisoxetine Lorpiprazole Zotepine Dasotraline
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545) Height ( 28552196)
Interacting Genes		7 interacting genes: A2M CALR CANX GPM6B STX1A VAMP2 YBX1	125 interacting genes: ACTA2 AKT1 ANKRD2 APBB1 CALM1 CASP8 CEBPA CSNK2A1 CTCF DANCR DUX4 FBXO33 FMR1 FUS GSK3B HABP4 HLA-C HNRNPD HNRNPK HOXC-AS3 IL7R IREB2 IRF1 JAM2 LCP2 LSM3 MAPK1 MIR1-1 MIR1-2 MIR106A MIR106B MIR107 MIR10B MIR122 MIR128-1 MIR128-2 MIR138-1 MIR138-2 MIR140 MIR141 MIR143 MIR145 MIR155 MIR15A MIR15B MIR16-1 MIR16-2 MIR17 MIR18A MIR18B MIR199A1 MIR199A2 MIR19A MIR19B1 MIR19B2 MIR200A MIR200B MIR200C MIR205 MIR206 MIR20A MIR20B MIR21 MIR214 MIR221 MIR222 MIR25 MIR29A MIR29B1 MIR29B2 MIR29C MIR31 MIR34A MIR34B MIR34C MIR363 MIR429 MIR451A MIR7-1 MIR7-2 MIR7-3 MIR9-1 MIR9-2 MIR9-3 MIR92A1 MIR92A2 MIR93 MIR98 MIRLET7A1 MIRLET7A2 MIRLET7A3 MIRLET7B MIRLET7C MIRLET7D MIRLET7E MIRLET7F1 MIRLET7F2 MIRLET7G MIRLET7I MYC MYCN NEIL3 NFYB OGT PCBP2 PCNA PFKFB4 PRPF40A PURA RBBP6 RNF10 RPS6KA1 RPS6KA3 SLC6A4 SMAD3 SMU1 SREK1 SRSF9 TFAP2A TP53 TRAF6 VEGFA VPS35 WEE2-AS1 ZBTB7A
Entrez ID		6532	4904
HPRD ID		01640	01095
Ensembl ID		ENSG00000108576	ENSG00000065978
Uniprot IDs		B2R7Y7 P31645	P67809
PDB IDs		5I6X 5I6Z 5I71 5I73 5I74 5I75 6AWN 6AWO 6AWP 6AWQ 6DZV 6DZW 6DZY 6DZZ 6VRH 6VRK 6VRL 6W2B 6W2C 7LI6 7LI7 7LI8 7LI9 7LIA 7LWD 7MGW 7TXT	1H95 5YTS 5YTT 5YTV 5YTX 6A6L 6KTC 6KUG 6LMR 6LMS
Enriched GO Terms of Interacting Partners?		Intracellular Protein Localization Synaptic Vesicle Endocytosis Presynaptic Endocytosis Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I Complex Synaptobrevin 2-SNAP-25-syntaxin-1a Complex Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II Complex Protein Transport Establishment Of Protein Localization Calcium-dependent Protein Binding Vesicle-mediated Transport In Synapse Protein Folding In Endoplasmic Reticulum SNARE Complex Assembly Protein Localization To Extracellular Region Protein Secretion Secretion By Cell Establishment Of Protein Localization To Extracellular Region Signal Release Endoplasmic Reticulum Quality Control Compartment Secretion Lumenal Side Of Endoplasmic Reticulum Membrane Synaptic Vesicle Exocytosis Calcium-ion Regulated Exocytosis SNAP Receptor Activity SNARE Complex Insulin Secretion SNARE Binding Peptide Hormone Secretion Myosin Head/neck Binding Peptide Secretion Voltage-gated Potassium Channel Complex Negative Regulation Of Complement Activation, Lectin Pathway ERAD Pathway Endocytosis Hormone Secretion Hormone Transport Homomeric SMAD Protein Complex Peptide Transport Organelle Membrane Fusion Regulated Exocytosis Vesicle Fusion Secretory Granule Interleukin-8 Binding Unfolded Protein Binding Response To Biphenyl Regulation Of Ossification Negative Regulation Of Serotonin Uptake Zygotic Specification Of Dorsal/ventral Axis Activin Responsive Factor Complex Paraxial Mesoderm Morphogenesis MiRNA Transport	MiRNA-mediated Post-transcriptional Gene Silencing RISC Complex Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Gene Silencing MRNA Base-pairing Post-transcriptional Repressor Activity Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Gene Expression Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process MRNA 3'-UTR Binding Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process MiRNA-mediated Gene Silencing By Inhibition Of Translation Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Translation MiRNA-mediated Gene Silencing By MRNA Destabilization Regulation Of Macromolecule Metabolic Process Extracellular Vesicle Regulation Of Metabolic Process Regulation Of Translation MRNA Destabilization RNA Destabilization Positive Regulation Of MRNA Catabolic Process Negative Regulation Of Developmental Process Regulation Of MRNA Stability Negative Regulation Of Protein Metabolic Process Negative Regulation Of Cell Migration Negative Regulation Of Cell Motility Regulation Of RNA Stability Negative Regulation Of Multicellular Organismal Process Regulation Of MRNA Metabolic Process Negative Regulation Of Locomotion Negative Regulation Of Vascular Endothelial Growth Factor Production Positive Regulation Of MRNA Metabolic Process Negative Regulation Of Angiogenesis Regulation Of Developmental Process Negative Regulation Of Vasculature Development Regulation Of Angiogenesis Regulation Of Vasculature Development Negative Regulation Of Cytokine Production Regulation Of Blood Vessel Endothelial Cell Migration Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Cell Migration Regulation Of Cellular Response To Growth Factor Stimulus Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Locomotion Regulation Of Cell Motility Regulation Of Protein Metabolic Process
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