SLC6A4

Name	solute carrier family 6 member 4
Structure
Novel Interactors	1 novel interactors: SMAD2
Interactors	7 interactors: A2M CALR CANX GPM6B STX1A VAMP2 YBX1
GO Annotations	Cellular Component	Endosome Plasma Membrane Focal Adhesion Endosome Membrane Endomembrane System Membrane Presynaptic Membrane Cell Projection Neuron Projection Membrane Raft Synapse Postsynaptic Membrane Anchoring Junction Serotonergic Synapse
	Molecular Function	Integrin Binding Monoatomic Cation Channel Activity Neurotransmitter Transmembrane Transporter Activity Serotonin:sodium:chloride Symporter Activity Protein Binding Monoamine Transmembrane Transporter Activity Antiporter Activity Syntaxin-1 Binding Cocaine Binding Sodium Ion Binding Identical Protein Binding Metal Ion Binding Nitric-oxide Synthase Binding Actin Filament Binding Serotonin Binding
	Biological Process	Response To Hypoxia Neurotransmitter Transport Serotonin Transport Amino Acid Transport Response To Nutrient Memory Circadian Rhythm Response To Xenobiotic Stimulus Response To Toxic Substance Positive Regulation Of Gene Expression Positive Regulation Of Serotonin Secretion Monoamine Transport Negative Regulation Of Cerebellar Granule Cell Precursor Proliferation Negative Regulation Of Synaptic Transmission, Dopaminergic Response To Estradiol Sodium Ion Transmembrane Transport Vasoconstriction Negative Regulation Of Neuron Differentiation Positive Regulation Of Cell Cycle Negative Regulation Of Organ Growth Behavioral Response To Cocaine Enteric Nervous System Development Brain Morphogenesis Serotonin Uptake Membrane Depolarization Male Mating Behavior Platelet Aggregation Cellular Response To Retinoic Acid Cellular Response To CGMP Regulation Of Thalamus Size Neurotransmitter Reuptake Conditioned Place Preference
Pathways	Serotonin clearance from the synaptic cleft SLC-mediated transport of neurotransmitters
Drugs	Fluvoxamine Amphetamine Phentermine Tramadol Citalopram Benzatropine Venlafaxine Atomoxetine Amitriptyline Protriptyline Loxapine Meperidine Imipramine Fluoxetine Duloxetine Dextromethorphan Nortriptyline Amoxapine Fenfluramine Mazindol Trazodone Verapamil Paroxetine Trimipramine Minaprine Pseudoephedrine Cocaine Cyclobenzaprine Dopamine Sertraline Sibutramine Chlorpheniramine Doxepin Nefazodone Desipramine Escitalopram Dexfenfluramine Aripiprazole Clomipramine Ephedra sinica root MMDA Midomafetamine 4-Methoxyamphetamine Metamfetamine Nomifensine Zimelidine Amineptine Bicifadine Milnacipran OPC-14523 CRx-119 Amitifadine Lumateperone Mianserin Tesofensine Tapentadol Vilazodone Desvenlafaxine Dexmethylphenidate Serotonin Levomilnacipran Butriptyline Vortioxetine Dosulepin Nisoxetine Lorpiprazole Zotepine Dasotraline
GWAS	Brain morphology (MOSTest) ( 32665545 ) Height ( 28552196 )
Entrez ID	6532
HPRD ID	01640
Ensembl ID	ENSG00000108576
Uniprot IDs	B2R7Y7 P31645
PDB IDs	5I6X 5I6Z 5I71 5I73 5I74 5I75 6AWN 6AWO 6AWP 6AWQ 6DZV 6DZW 6DZY 6DZZ 6VRH 6VRK 6VRL 6W2B 6W2C 7LI6 7LI7 7LI8 7LI9 7LIA 7LWD 7MGW 7TXT
GO Terms Enriched among Interactors ?	Intracellular Protein Localization Synaptic Vesicle Endocytosis Presynaptic Endocytosis Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I Complex Synaptobrevin 2-SNAP-25-syntaxin-1a Complex Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II Complex Protein Transport Establishment Of Protein Localization Calcium-dependent Protein Binding Vesicle-mediated Transport In Synapse Protein Folding In Endoplasmic Reticulum SNARE Complex Assembly Protein Localization To Extracellular Region Protein Secretion Secretion By Cell Establishment Of Protein Localization To Extracellular Region Signal Release Endoplasmic Reticulum Quality Control Compartment Secretion Lumenal Side Of Endoplasmic Reticulum Membrane Synaptic Vesicle Exocytosis Calcium-ion Regulated Exocytosis SNAP Receptor Activity SNARE Complex Insulin Secretion SNARE Binding Peptide Hormone Secretion Myosin Head/neck Binding Peptide Secretion Voltage-gated Potassium Channel Complex Negative Regulation Of Complement Activation, Lectin Pathway ERAD Pathway Endocytosis Hormone Secretion Hormone Transport Homomeric SMAD Protein Complex Peptide Transport Organelle Membrane Fusion Regulated Exocytosis Vesicle Fusion Secretory Granule Interleukin-8 Binding Unfolded Protein Binding Response To Biphenyl Regulation Of Ossification Negative Regulation Of Serotonin Uptake Zygotic Specification Of Dorsal/ventral Axis Activin Responsive Factor Complex Paraxial Mesoderm Morphogenesis MiRNA Transport