LCT

Name	lactase
Structure	No pdb structure
Interactors	2 interactors: CANX HSPA5
GO Annotations	Cellular Component	Plasma Membrane Membrane Apical Plasma Membrane External Side Of Apical Plasma Membrane
	Molecular Function	Lactase Activity Catalytic Activity Galactosylceramidase Activity Glucosylceramidase Activity Hydrolase Activity, Hydrolyzing O-glycosyl Compounds Beta-glucosidase Activity Hydrolase Activity Hydrolase Activity, Acting On Glycosyl Bonds Protein Homodimerization Activity Cellobiose Glucosidase Activity Phlorizin Hydrolase Activity
	Biological Process	Carbohydrate Metabolic Process Lactose Catabolic Process Glycosylceramide Catabolic Process Quercetin Catabolic Process Cellobiose Catabolic Process
Pathways	Digestion of dietary carbohydrate Intestinal saccharidase deficiencies
Drugs	D-gluconhydroximo-1,5-lactam Nojirimycine Tetrazole alpha-D-Xylopyranose 2-deoxy-2-fluoro-α-D-glucose Gluconolactone (1S,2S,3R,4S,5S)-2,3,4-TRIHYDROXY-5-(HYDROXYMETHYL)CYCLOHEXYL (1E)-2-PHENYL-N-(SULFOOXY)ETHANIMIDOTHIOATE ETHYL (1E)-2-PHENYL-N-(SULFOOXY)ETHANIMIDOTHIOATE 2-HYDROXYMETHYL-6-OCTYLSULFANYL-TETRAHYDRO-PYRAN-3,4,5-TRIOL
Diseases	Congenital lactase deficiency; Disaccharide intolerance II
GWAS	Aspartate aminotransferase levels ( 33547301 ) Blood protein levels ( 30072576 ) Body mass index ( 26426971 ) Distal colorectal cancer ( 33632709 ) Distal/Left-sided colorectal cancer ( 33632709 ) Lactose tolerance test ( 31791255 ) Lung function (FVC) ( 30175238 ) Monocyte count ( 32888494 ) Neutrophil count ( 32888494 ) Neutrophil percentage of white cells ( 32888494 ) Plasma omega-3 polyunsaturated fatty acid levels (alphalinolenic acid) ( 21829377 ) Urinary metabolite levels in chronic kidney disease ( 31959995 ) White blood cell count ( 32888494 )
Entrez ID	3938
HPRD ID	04437
Ensembl ID	ENSG00000115850
Uniprot IDs	P09848
PDB IDs	Not available
GO Terms Enriched among Interactors ?	Protein Folding In Endoplasmic Reticulum Unfolded Protein Binding ERAD Pathway Protein Folding Regulation Of Protein Folding In Endoplasmic Reticulum Response To Endoplasmic Reticulum Stress Cerebellum Structural Organization Endoplasmic Reticulum Lumen Regulation Of ATF6-mediated Unfolded Protein Response Proteasomal Protein Catabolic Process Protein Catabolic Process Calcium Ion Binding Regulation Of Protein Folding Maintenance Of Protein Localization In Endoplasmic Reticulum PERK-mediated Unfolded Protein Response ER Overload Response Post-translational Protein Targeting To Membrane, Translocation Endoplasmic Reticulum Chaperone Complex Negative Regulation Of PERK-mediated Unfolded Protein Response IRE1-mediated Unfolded Protein Response Cerebellar Purkinje Cell Layer Development Negative Regulation Of IRE1-mediated Unfolded Protein Response Proteolysis Involved In Protein Catabolic Process Regulation Of IRE1-mediated Unfolded Protein Response Regulation Of PERK-mediated Unfolded Protein Response Misfolded Protein Binding Anatomical Structure Arrangement Mitochondria-associated Endoplasmic Reticulum Membrane Contact Site Melanosome Membrane Endoplasmic Reticulum Quality Control Compartment Cellular Response To Interleukin-4 Negative Regulation Of Endoplasmic Reticulum Unfolded Protein Response Protein Serine/threonine Kinase Inhibitor Activity Viral Protein Processing Response To Interleukin-4 Protein Refolding Macromolecule Catabolic Process Endoplasmic Reticulum Membrane Lumenal Side Of Endoplasmic Reticulum Membrane Clathrin-dependent Endocytosis Intracellular Protein Transmembrane Transport Protein Transport COP9 Signalosome Regulation Of Endoplasmic Reticulum Unfolded Protein Response ER-nucleus Signaling Pathway ATP-dependent Protein Folding Chaperone Synaptic Vesicle Endocytosis Integrated Stress Response Signaling Proteolysis Presynaptic Endocytosis