LCT and HSPA5

Number of citations of the paper that reports this interaction (PubMedID 11751874)
0

Data Source:
HPRD (in vivo)

		LCT	HSPA5
Description		lactase	heat shock protein family A (Hsp70) member 5
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane Apical Plasma Membrane External Side Of Apical Plasma Membrane	Nucleus Cytoplasm Mitochondrion Endoplasmic Reticulum Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Cytosol Plasma Membrane Focal Adhesion COP9 Signalosome Cell Surface Membrane Midbody Protein-containing Complex Endoplasmic Reticulum Chaperone Complex Melanosome Intracellular Membrane-bounded Organelle Extracellular Exosome
	Molecular Function	Lactase Activity Catalytic Activity Galactosylceramidase Activity Glucosylceramidase Activity Hydrolase Activity, Hydrolyzing O-glycosyl Compounds Beta-glucosidase Activity Hydrolase Activity Hydrolase Activity, Acting On Glycosyl Bonds Protein Homodimerization Activity Cellobiose Glucosidase Activity Phlorizin Hydrolase Activity	Nucleotide Binding Calcium Ion Binding Protein Binding ATP Binding Hydrolase Activity ATP Hydrolysis Activity Enzyme Binding Protein Domain Specific Binding Protein Serine/threonine Kinase Inhibitor Activity Heat Shock Protein Binding Ubiquitin Protein Ligase Binding Ribosome Binding Protein Folding Chaperone Cadherin Binding Unfolded Protein Binding Protein-folding Chaperone Binding Misfolded Protein Binding ATP-dependent Protein Folding Chaperone
	Biological Process	Carbohydrate Metabolic Process Lactose Catabolic Process Glycosylceramide Catabolic Process Quercetin Catabolic Process Cellobiose Catabolic Process	Translational Initiation Protein Folding ER Overload Response Cerebellum Structural Organization Cerebellar Purkinje Cell Layer Development Substantia Nigra Development Positive Regulation Of Cell Migration Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Endoplasmic Reticulum Unfolded Protein Response Post-translational Protein Targeting To Membrane, Translocation Negative Regulation Of Protein-containing Complex Assembly Positive Regulation Of Protein Ubiquitination Protein Folding In Endoplasmic Reticulum Response To Endoplasmic Reticulum Stress Maintenance Of Protein Localization In Endoplasmic Reticulum IRE1-mediated Unfolded Protein Response PERK-mediated Unfolded Protein Response ERAD Pathway Protein Refolding Cellular Response To Glucose Starvation Negative Regulation Of Apoptotic Process Positive Regulation Of Transcription By RNA Polymerase II Proteolysis Involved In Protein Catabolic Process Regulation Of Protein Folding In Endoplasmic Reticulum Cellular Response To Interleukin-4 Regulation Of ATF6-mediated Unfolded Protein Response Regulation Of IRE1-mediated Unfolded Protein Response Negative Regulation Of IRE1-mediated Unfolded Protein Response Regulation Of PERK-mediated Unfolded Protein Response Negative Regulation Of PERK-mediated Unfolded Protein Response
Pathways		Digestion of dietary carbohydrate Intestinal saccharidase deficiencies	Platelet degranulation Regulation of HSF1-mediated heat shock response ATF6 (ATF6-alpha) activates chaperones PERK regulates gene expression IRE1alpha activates chaperones ATF6 (ATF6-alpha) activates chaperone genes ATF6B (ATF6-beta) activates chaperones Antigen Presentation: Folding, assembly and peptide loading of class I MHC Antigen Presentation: Folding, assembly and peptide loading of class I MHC Modulation of host responses by IFN-stimulated genes
Drugs		D-gluconhydroximo-1,5-lactam Nojirimycine Tetrazole alpha-D-Xylopyranose 2-deoxy-2-fluoro-α-D-glucose Gluconolactone (1S,2S,3R,4S,5S)-2,3,4-TRIHYDROXY-5-(HYDROXYMETHYL)CYCLOHEXYL (1E)-2-PHENYL-N-(SULFOOXY)ETHANIMIDOTHIOATE ETHYL (1E)-2-PHENYL-N-(SULFOOXY)ETHANIMIDOTHIOATE 2-HYDROXYMETHYL-6-OCTYLSULFANYL-TETRAHYDRO-PYRAN-3,4,5-TRIOL	Antihemophilic factor, human recombinant Acetylsalicylic acid Copper Lonoctocog alfa Moroctocog alfa
Diseases		Congenital lactase deficiency; Disaccharide intolerance II
GWAS		Aspartate aminotransferase levels ( 33547301) Blood protein levels ( 30072576) Body mass index ( 26426971) Distal colorectal cancer ( 33632709) Distal/Left-sided colorectal cancer ( 33632709) Lactose tolerance test ( 31791255) Lung function (FVC) ( 30175238) Monocyte count ( 32888494) Neutrophil count ( 32888494) Neutrophil percentage of white cells ( 32888494) Plasma omega-3 polyunsaturated fatty acid levels (alphalinolenic acid) ( 21829377) Urinary metabolite levels in chronic kidney disease ( 31959995) White blood cell count ( 32888494)	Refractive error ( 32231278) Smoking initiation ( 33082346)
Interacting Genes		2 interacting genes: CANX HSPA5	77 interacting genes: A2M AGO4 APC APOB BAG3 BCAR1 CASP7 CDK7 CPT1A DDX24 DNAJC1 DNAJC10 DPH1 DPYSL5 EIF2AK3 ERBB2 ERCC6 ERN1 ERP29 F8 FCHSD2 FNDC3B GRIA1 HLA-C HMGB1 HSPBP1 HTR3A IGHM KRT14 KRT18 KRT8 LCT LDLR LINC01554 MATK METTL21A MTNR1A MTNR1B NDRG1 NEDD4L NRIP1 OTUD3 PARK7 PAWR PCSK7 PRDM14 PRNP PSME3 PTPN11 PTPRF RIPK4 RNF114 RNF26 RPN1 SEC61A1 SEC63 SERPINB5 SH3BP4 SIL1 SIRPA SQSTM1 SREBF2 STMN1 SUMO2 SUMO4 TCERG1 TG TMEM132A TMEM62 TRA TSHR UBE3A UBQLN4 VHL VWF XAF1 YWHAB
Entrez ID		3938	3309
HPRD ID		04437	00682
Ensembl ID		ENSG00000115850	ENSG00000044574
Uniprot IDs		P09848	P11021 V9HWB4
PDB IDs			3IUC 3LDL 3LDN 3LDO 3LDP 5E84 5E85 5E86 5EVZ 5EX5 5EXW 5EY4 5F0X 5F1X 5F2R 6ASY 6CZ1 6DFM 6DFO 6DO2 6DWS 6ZMD 7N1R
Enriched GO Terms of Interacting Partners?		Protein Folding In Endoplasmic Reticulum Unfolded Protein Binding ERAD Pathway Protein Folding Regulation Of Protein Folding In Endoplasmic Reticulum Response To Endoplasmic Reticulum Stress Cerebellum Structural Organization Endoplasmic Reticulum Lumen Regulation Of ATF6-mediated Unfolded Protein Response Proteasomal Protein Catabolic Process Protein Catabolic Process Calcium Ion Binding Regulation Of Protein Folding Maintenance Of Protein Localization In Endoplasmic Reticulum PERK-mediated Unfolded Protein Response ER Overload Response Post-translational Protein Targeting To Membrane, Translocation Endoplasmic Reticulum Chaperone Complex Negative Regulation Of PERK-mediated Unfolded Protein Response IRE1-mediated Unfolded Protein Response Cerebellar Purkinje Cell Layer Development Negative Regulation Of IRE1-mediated Unfolded Protein Response Proteolysis Involved In Protein Catabolic Process Regulation Of IRE1-mediated Unfolded Protein Response Regulation Of PERK-mediated Unfolded Protein Response Misfolded Protein Binding Anatomical Structure Arrangement Mitochondria-associated Endoplasmic Reticulum Membrane Contact Site Melanosome Membrane Endoplasmic Reticulum Quality Control Compartment Cellular Response To Interleukin-4 Negative Regulation Of Endoplasmic Reticulum Unfolded Protein Response Protein Serine/threonine Kinase Inhibitor Activity Viral Protein Processing Response To Interleukin-4 Protein Refolding Macromolecule Catabolic Process Endoplasmic Reticulum Membrane Lumenal Side Of Endoplasmic Reticulum Membrane Clathrin-dependent Endocytosis Intracellular Protein Transmembrane Transport Protein Transport COP9 Signalosome Regulation Of Endoplasmic Reticulum Unfolded Protein Response ER-nucleus Signaling Pathway ATP-dependent Protein Folding Chaperone Synaptic Vesicle Endocytosis Integrated Stress Response Signaling Proteolysis Presynaptic Endocytosis	Macromolecule Catabolic Process Regulation Of Protein Localization Endoplasmic Reticulum Protein Metabolic Process Regulation Of Establishment Of Protein Localization Positive Regulation Of Catabolic Process Catabolic Process Protein-folding Chaperone Binding Protein Catabolic Process Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process Modification-dependent Protein Catabolic Process Regulation Of Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Regulation Of Autophagy Negative Regulation Of Establishment Of Protein Localization Adenyl-nucleotide Exchange Factor Activity Cotranslational Protein Targeting To Membrane Molecular Sequestering Activity Proteolysis Protein Modification Process Negative Regulation Of Signaling Regulation Of Protein Metabolic Process Negative Regulation Of Metabolic Process Melatonin Receptor Activity Regulation Of Metabolic Process Negative Regulation Of Transport Response To Stress Regulation Of Protein Transport Regulation Of Apoptotic Process Cellular Response To Stress Regulation Of Signal Transduction Signal Transduction Immunoglobulin Binding Cupric Ion Binding Negative Regulation Of Protein Transport Regulation Of Programmed Cell Death Negative Regulation Of Cell Communication Regulation Of Signaling Negative Regulation Of Leukocyte Activation Scaffold Protein Binding Regulation Of Type I Interferon Production Regulation Of Proteolysis Protein Folding Positive Regulation Of Transcription By RNA Polymerase I Negative Regulation Of T Cell Proliferation Positive Regulation Of Cholesterol Storage Negative Regulation Of T Cell Activation Ubiquitin-like Protein Conjugating Enzyme Binding
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