ITGB1 and ITGAV

Number of citations of the paper that reports this interaction (PubMedID 40437099)
172

Data Source:
BioGRID (pull down, imaging technique, biochemical)
HPRD (in vivo)

		ITGB1	ITGAV
Description		integrin subunit beta 1	integrin subunit alpha V
Image
GO Annotations	Cellular Component	Ruffle Cytoplasm Endosome Plasma Membrane Focal Adhesion Integrin Complex External Side Of Plasma Membrane Cell Surface Endosome Membrane Intercalated Disc Membrane Lamellipodium Filopodium Cytoplasmic Vesicle Neuromuscular Junction Cleavage Furrow Ruffle Membrane Integrin Alpha1-beta1 Complex Integrin Alpha2-beta1 Complex Integrin Alpha3-beta1 Complex Integrin Alpha4-beta1 Complex Integrin Alpha5-beta1 Complex Integrin Alpha6-beta1 Complex Integrin Alpha7-beta1 Complex Integrin Alpha8-beta1 Complex Integrin Alpha9-beta1 Complex Integrin Alpha10-beta1 Complex Integrin Alpha11-beta1 Complex Integrin Alphav-beta1 Complex Myelin Sheath Abaxonal Region Sarcolemma Melanosome Cell Projection Dendritic Spine Receptor Complex Membrane Raft Synapse Perinuclear Region Of Cytoplasm Recycling Endosome Extracellular Exosome Anchoring Junction Synaptic Membrane Glial Cell Projection Schaffer Collateral - CA1 Synapse Glutamatergic Synapse Cerebellar Climbing Fiber To Purkinje Cell Synapse	Cytosol Plasma Membrane Focal Adhesion Integrin Complex External Side Of Plasma Membrane Cell Surface Membrane Lamellipodium Membrane Filopodium Membrane Microvillus Membrane Ruffle Membrane Integrin Alphav-beta1 Complex Integrin Alphav-beta3 Complex Integrin Alphav-beta5 Complex Integrin Alphav-beta6 Complex Integrin Alphav-beta8 Complex Specific Granule Membrane Alphav-beta3 Integrin-PKCalpha Complex Alphav-beta3 Integrin-IGF-1-IGF1R Complex Alphav-beta3 Integrin-HMGB1 Complex Phagocytic Vesicle Extracellular Exosome Anchoring Junction
	Molecular Function	Magnesium Ion Binding Virus Receptor Activity Fibronectin Binding Protease Binding Actin Binding Integrin Binding Calcium Ion Binding Protein Binding Coreceptor Activity Protein Kinase Binding C-X3-C Chemokine Binding Signaling Receptor Activity Laminin Binding Protein-containing Complex Binding Cadherin Binding Metal Ion Binding Protein Heterodimerization Activity Cell Adhesion Molecule Binding Collagen Binding Involved In Cell-matrix Adhesion Integrin Binding Involved In Cell-matrix Adhesion Protein Tyrosine Kinase Binding	Virus Receptor Activity Opsonin Binding Fibronectin Binding Protease Binding Protein Kinase C Binding Signaling Receptor Binding Integrin Binding Protein Binding Coreceptor Activity Fibroblast Growth Factor Binding C-X3-C Chemokine Binding Insulin-like Growth Factor I Binding Signaling Receptor Activity Neuregulin Binding Metal Ion Binding Transforming Growth Factor Beta Binding Extracellular Matrix Binding Extracellular Matrix Protein Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Establishment Of Mitotic Spindle Orientation Angiogenesis In Utero Embryonic Development Cell Migration Involved In Sprouting Angiogenesis Positive Regulation Of Neuroblast Proliferation Phagocytosis Cellular Defense Response Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Leukocyte Cell-cell Adhesion Cell-matrix Adhesion Calcium-independent Cell-matrix Adhesion Transforming Growth Factor Beta Receptor Signaling Pathway Integrin-mediated Signaling Pathway Neuroblast Proliferation Muscle Organ Development Myoblast Fusion Cell Population Proliferation Germ Cell Migration Visual Learning Regulation Of Collagen Catabolic Process Positive Regulation Of Fibroblast Migration Response To Muscle Activity Cell Migration Formation Of Radial Glial Scaffolds Central Nervous System Neuron Differentiation CD40 Signaling Pathway Cell Projection Organization Lamellipodium Assembly B Cell Differentiation Extracellular Matrix Organization Positive Regulation Of Cell Migration Neuron Projection Development Cell-substrate Adhesion Receptor Internalization Cell Adhesion Mediated By Integrin Cell-cell Adhesion Mediated By Integrin Heterotypic Cell-cell Adhesion Negative Regulation Of Rho Protein Signal Transduction Wound Healing, Spreading Of Epidermal Cells Maintenance Of Blood-brain Barrier Positive Regulation Of Apoptotic Process Stress Fiber Assembly Positive Regulation Of GTPase Activity Sarcomere Organization Myoblast Differentiation Negative Regulation Of Neuron Differentiation Positive Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of Angiogenesis Negative Regulation Of Vasoconstriction Symbiont Entry Into Host Cell Mesodermal Cell Differentiation Myoblast Fate Specification Axon Extension Dendrite Morphogenesis Regulation Of Developmental Process Modulation Of Chemical Synaptic Transmission Leukocyte Tethering Or Rolling Regulation Of Cell Cycle Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Glutamate Uptake Involved In Transmission Of Nerve Impulse Cardiac Muscle Cell Differentiation Cardiac Muscle Cell Myoblast Differentiation Cardiac Cell Fate Specification Regulation Of Biological Quality Cellular Response To Low-density Lipoprotein Particle Stimulus Basement Membrane Organization Positive Regulation Of Wound Healing Cell-cell Adhesion Regulation Of Spontaneous Synaptic Transmission Reactive Gliosis Positive Regulation Of Vascular Endothelial Growth Factor Signaling Pathway Positive Regulation Of Protein Localization To Plasma Membrane Regulation Of Synapse Pruning Negative Regulation Of Anoikis	Angiogenesis Blood Vessel Development Vasculogenesis Formation Of Primary Germ Layer Cell Adhesion Cell-matrix Adhesion Positive Regulation Of Cytosolic Calcium Ion Concentration Integrin-mediated Signaling Pathway Positive Regulation Of Cell Population Proliferation Tissue Development Negative Regulation Of Macrophage Derived Foam Cell Differentiation Negative Regulation Of Lipid Storage Negative Regulation Of Low-density Lipoprotein Particle Clearance Cell Migration Positive Regulation Of Cell Migration Cell-substrate Adhesion Negative Regulation Of Lipid Transport Cell Adhesion Mediated By Integrin Positive Regulation Of Osteoblast Proliferation Heterotypic Cell-cell Adhesion Substrate Adhesion-dependent Cell Spreading Wound Healing, Spreading Of Epidermal Cells Endodermal Cell Differentiation Apolipoprotein A-I-mediated Signaling Pathway Apoptotic Cell Clearance Positive Regulation Of Cell Adhesion Symbiont Entry Into Host Cell Negative Regulation Of Lipoprotein Metabolic Process Regulation Of Phagocytosis Negative Chemotaxis Positive Regulation Of Small GTPase Mediated Signal Transduction ERK1 And ERK2 Cascade Calcium Ion Transmembrane Transport Transforming Growth Factor Beta Production Entry Into Host Cell By A Symbiont-containing Vacuole Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Cell-cell Adhesion Positive Regulation Of Intracellular Signal Transduction Negative Regulation Of Entry Of Bacterium Into Host Cell Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways		Elastic fibre formation Fibronectin matrix formation Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Cell surface interactions at the vascular wall Basigin interactions Molecules associated with elastic fibres Integrin cell surface interactions Integrin cell surface interactions TGF-beta receptor signaling activates SMADs Laminin interactions Laminin interactions Syndecan interactions ECM proteoglycans Other semaphorin interactions Signal transduction by L1 Localization of the PINCH-ILK-PARVIN complex to focal adhesions CHL1 interactions RHO GTPases Activate Formins Interleukin-4 and Interleukin-13 signaling Platelet Adhesion to exposed collagen MET activates PTK2 signaling MET interacts with TNS proteins RAC1 GTPase cycle RAC2 GTPase cycle RHOG GTPase cycle RAC3 GTPase cycle HCMV Early Events GPER1 signaling Potential therapeutics for SARS Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin Formation of the ureteric bud Mechanical load activates signaling by PIEZO1 and integrins in osteocytes Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells Developmental Lineage of Mammary Gland Luminal Epithelial Cells Developmental Lineage of Mammary Gland Myoepithelial Cells Developmental Lineage of Mammary Stem Cells	Cross-presentation of particulate exogenous antigens (phagosomes) Elastic fibre formation PECAM1 interactions Molecules associated with elastic fibres Integrin cell surface interactions Integrin cell surface interactions TGF-beta receptor signaling activates SMADs Laminin interactions Syndecan interactions Syndecan interactions ECM proteoglycans VEGFA-VEGFR2 Pathway Signal transduction by L1 Neutrophil degranulation Mechanical load activates signaling by PIEZO1 and integrins in osteocytes Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells
Drugs		Antithymocyte immunoglobulin (rabbit) MK-0668 PLN-74809	Antithymocyte immunoglobulin (rabbit) Levothyroxine PLN-74809
Diseases
GWAS		Depression (quantitative trait) ( 20800221) Suicide in bipolar disorder ( 25917933)	Asthma ( 32296059) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) Left-handedness ( 32989287) Lung function (FEV1/FVC) ( 30804560) Microalbuminuria ( 26631737) Urinary albumin-to-creatinine ratio ( 26631737) Urinary albumin-to-creatinine ratio in non-diabetics ( 26631737)
Interacting Genes		80 interacting genes: ACAP1 ACTN1 ACTN4 ARHGAP5 CANX CD151 CD274 CD36 CD46 CD82 CD9 CD93 COL18A1 CRKL DAG1 DOK1 EGFR ENO1 EPS8 FBLN1 FBXO2 FERMT1 FERMT2 FERMT3 FHL2 FLNA FLNB FLT4 FN1 HSPD1 HSPG2 ICAM4 IGF1R ILK ITGA1 ITGA10 ITGA11 ITGA2 ITGA3 ITGA4 ITGA5 ITGA6 ITGA8 ITGA9 ITGAV ITGB1BP1 ITGB1BP2 LAMA1 LAMTOR5 LGALS1 LGALS3BP LGALS8 MAP4K4 MET NCKIPSD NF2 NGF NME1 NMRK2 PDHB PIP5K1C PLAUR PRKCA PRKCE PTK2 PXN RAB25 RACK1 SLC3A2 SPP1 TGM2 TGOLN2 TIMP2 TLN1 TSPAN4 TSPAN7 UPF2 VCAM1 VCAN YWHAB	38 interacting genes: ADAM9 ANGPTL3 AUP1 AZGP1 CALR CCN1 CCN3 CD47 COL11A1 COL18A1 COL6A1 EDIL3 F2R ICAM4 ITGB1 ITGB3 ITGB5 ITGB6 ITGB8 L1CAM LGALS3BP MAPK3 MMP14 MMP2 NID1 P2RY2 PAK4 PDGFRA PLA2G2A PLP1 PTK2 PXN SPP1 TGFB1 TGM2 THY1 UBC VTN
Entrez ID		3688	3685
HPRD ID		00628	01903
Ensembl ID		ENSG00000150093	ENSG00000138448
Uniprot IDs		P05556	L7RXH0 P06756
PDB IDs		3G9W 3T9K 3VI3 3VI4 4DX9 4WJK 4WK0 4WK2 4WK4 7CEB 7CEC 7NWL 7NXD 8RPQ 8W30 9B9J 9B9K 9CKV	1JV2 1L5G 1M1X 1U8C 3IJE 4G1E 4G1M 4MMX 4MMY 4MMZ 4O02 4UM8 4UM9 5FFG 5FFO 5NEM 5NER 5NET 5NEU 6AVQ 6AVR 6AVU 6DJP 6MK0 6MSL 6MSU 6NAJ 6OM1 6OM2 6UJA 6UJB 6UJC 7Y1T 8IJ5 8TCF 8TCG 8VS6 8VSD 8W30 8XEI 8XEK 8XEL 8XEN 8XER 8XEZ 8XF6 8XFG 8XFO 9CZ7 9CZA 9CZD 9CZF 9IND
Enriched GO Terms of Interacting Partners?		Integrin Binding Focal Adhesion Cell Adhesion Integrin-mediated Signaling Pathway Cell-matrix Adhesion Cell-substrate Adhesion Regulation Of Cell Adhesion Positive Regulation Of Cell Adhesion Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Regulation Of Cell Migration Integrin Complex Regulation Of Cell Motility Regulation Of Locomotion Cell Surface Regulation Of Cell-substrate Adhesion Plasma Membrane Cell Migration Positive Regulation Of Cell-substrate Adhesion Cell-cell Adhesion Cell Surface Receptor Signaling Pathway Cell Motility Signal Transduction Regulation Of Cell Population Proliferation Regulation Of Cell Communication Regulation Of Signal Transduction Positive Regulation Of Cell Population Proliferation Anchoring Junction Regulation Of Signaling Regulation Of Intracellular Signal Transduction Regulation Of Programmed Cell Death Regulation Of Multicellular Organismal Process Extracellular Exosome Signaling Receptor Activity Substrate Adhesion-dependent Cell Spreading Regulation Of Apoptotic Process Membrane Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Cell Communication Cell-substrate Junction Assembly Anatomical Structure Morphogenesis Cell-substrate Junction Organization Integrin Activation Positive Regulation Of Signal Transduction Ruffle Membrane Regulation Of Cellular Component Organization Collagen Binding Involved In Cell-matrix Adhesion Positive Regulation Of Signaling Positive Regulation Of Cellular Component Organization	Integrin Binding Cell Adhesion Integrin-mediated Signaling Pathway Cell Adhesion Mediated By Integrin Focal Adhesion Extracellular Matrix Positive Regulation Of Cell Migration Cell-matrix Adhesion Positive Regulation Of Cell Motility Cell-substrate Adhesion Positive Regulation Of Locomotion Angiogenesis Cell-cell Adhesion Cell Migration Regulation Of Cell Adhesion Anatomical Structure Formation Involved In Morphogenesis Regulation Of Cell Migration Regulation Of Cell Motility Cell Motility Regulation Of Locomotion Cell Surface Enzyme-linked Receptor Protein Signaling Pathway Extracellular Matrix Binding Transforming Growth Factor Beta Receptor Signaling Pathway Extracellular Matrix Organization Extracellular Structure Organization Endodermal Cell Differentiation Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Extracellular Region Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Multicellular Organismal Process Signal Transduction Cell Surface Receptor Signaling Pathway Regulation Of Mononuclear Cell Migration Regulation Of Cell-substrate Adhesion Positive Regulation Of Leukocyte Migration Regulation Of Leukocyte Migration Extracellular Exosome Positive Regulation Of Mononuclear Cell Migration Positive Regulation Of Multicellular Organismal Process Integrin Complex Developmental Process Regulation Of Cellular Component Organization Positive Regulation Of Cell Adhesion Response To Mechanical Stimulus Positive Regulation Of Cell-substrate Adhesion Cellular Developmental Process Cell Differentiation Extracellular Space Positive Regulation Of Fibroblast Migration
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