ITGB1 and PXN

Number of citations of the paper that reports this interaction (PubMedID 10804218)
62

Data Source:
HPRD (in vivo, in vitro)

		ITGB1	PXN
Description		integrin subunit beta 1	paxillin
Image
GO Annotations	Cellular Component	Ruffle Cytoplasm Endosome Plasma Membrane Focal Adhesion Integrin Complex External Side Of Plasma Membrane Cell Surface Endosome Membrane Intercalated Disc Membrane Lamellipodium Filopodium Cytoplasmic Vesicle Neuromuscular Junction Cleavage Furrow Ruffle Membrane Integrin Alpha1-beta1 Complex Integrin Alpha2-beta1 Complex Integrin Alpha3-beta1 Complex Integrin Alpha4-beta1 Complex Integrin Alpha5-beta1 Complex Integrin Alpha6-beta1 Complex Integrin Alpha7-beta1 Complex Integrin Alpha8-beta1 Complex Integrin Alpha9-beta1 Complex Integrin Alpha10-beta1 Complex Integrin Alpha11-beta1 Complex Integrin Alphav-beta1 Complex Myelin Sheath Abaxonal Region Sarcolemma Melanosome Cell Projection Dendritic Spine Receptor Complex Membrane Raft Synapse Perinuclear Region Of Cytoplasm Recycling Endosome Extracellular Exosome Anchoring Junction Synaptic Membrane Glial Cell Projection Schaffer Collateral - CA1 Synapse Glutamatergic Synapse Cerebellar Climbing Fiber To Purkinje Cell Synapse	Stress Fiber Cytoplasm Cytosol Cytoskeleton Microtubule Associated Complex Plasma Membrane Cell-cell Junction Focal Adhesion Cell Cortex Lamellipodium Anchoring Junction
	Molecular Function	Magnesium Ion Binding Virus Receptor Activity Fibronectin Binding Protease Binding Actin Binding Integrin Binding Calcium Ion Binding Protein Binding Coreceptor Activity Protein Kinase Binding C-X3-C Chemokine Binding Signaling Receptor Activity Laminin Binding Protein-containing Complex Binding Cadherin Binding Metal Ion Binding Protein Heterodimerization Activity Cell Adhesion Molecule Binding Collagen Binding Involved In Cell-matrix Adhesion Integrin Binding Involved In Cell-matrix Adhesion Protein Tyrosine Kinase Binding	Protein Binding Beta-catenin Binding Vinculin Binding Protein Phosphatase Binding Neuropilin Binding Metal Ion Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Establishment Of Mitotic Spindle Orientation Angiogenesis In Utero Embryonic Development Cell Migration Involved In Sprouting Angiogenesis Positive Regulation Of Neuroblast Proliferation Phagocytosis Cellular Defense Response Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Leukocyte Cell-cell Adhesion Cell-matrix Adhesion Calcium-independent Cell-matrix Adhesion Transforming Growth Factor Beta Receptor Signaling Pathway Integrin-mediated Signaling Pathway Neuroblast Proliferation Muscle Organ Development Myoblast Fusion Cell Population Proliferation Germ Cell Migration Visual Learning Regulation Of Collagen Catabolic Process Positive Regulation Of Fibroblast Migration Response To Muscle Activity Cell Migration Formation Of Radial Glial Scaffolds Central Nervous System Neuron Differentiation CD40 Signaling Pathway Cell Projection Organization Lamellipodium Assembly B Cell Differentiation Extracellular Matrix Organization Positive Regulation Of Cell Migration Neuron Projection Development Cell-substrate Adhesion Receptor Internalization Cell Adhesion Mediated By Integrin Cell-cell Adhesion Mediated By Integrin Heterotypic Cell-cell Adhesion Negative Regulation Of Rho Protein Signal Transduction Wound Healing, Spreading Of Epidermal Cells Maintenance Of Blood-brain Barrier Positive Regulation Of Apoptotic Process Stress Fiber Assembly Positive Regulation Of GTPase Activity Sarcomere Organization Myoblast Differentiation Negative Regulation Of Neuron Differentiation Positive Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of Angiogenesis Negative Regulation Of Vasoconstriction Symbiont Entry Into Host Cell Mesodermal Cell Differentiation Myoblast Fate Specification Axon Extension Dendrite Morphogenesis Regulation Of Developmental Process Modulation Of Chemical Synaptic Transmission Leukocyte Tethering Or Rolling Regulation Of Cell Cycle Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Glutamate Uptake Involved In Transmission Of Nerve Impulse Cardiac Muscle Cell Differentiation Cardiac Muscle Cell Myoblast Differentiation Cardiac Cell Fate Specification Regulation Of Biological Quality Cellular Response To Low-density Lipoprotein Particle Stimulus Basement Membrane Organization Positive Regulation Of Wound Healing Cell-cell Adhesion Regulation Of Spontaneous Synaptic Transmission Reactive Gliosis Positive Regulation Of Vascular Endothelial Growth Factor Signaling Pathway Positive Regulation Of Protein Localization To Plasma Membrane Regulation Of Synapse Pruning Negative Regulation Of Anoikis	Cell Adhesion Signal Transduction Signal Complex Assembly Transforming Growth Factor Beta Receptor Signaling Pathway Cell Migration Substrate Adhesion-dependent Cell Spreading Cellular Response To Reactive Oxygen Species Endothelial Cell Migration Positive Regulation Of Stress Fiber Assembly Growth Hormone Receptor Signaling Pathway
Pathways		Elastic fibre formation Fibronectin matrix formation Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Cell surface interactions at the vascular wall Basigin interactions Molecules associated with elastic fibres Integrin cell surface interactions Integrin cell surface interactions TGF-beta receptor signaling activates SMADs Laminin interactions Laminin interactions Syndecan interactions ECM proteoglycans Other semaphorin interactions Signal transduction by L1 Localization of the PINCH-ILK-PARVIN complex to focal adhesions CHL1 interactions RHO GTPases Activate Formins Interleukin-4 and Interleukin-13 signaling Platelet Adhesion to exposed collagen MET activates PTK2 signaling MET interacts with TNS proteins RAC1 GTPase cycle RAC2 GTPase cycle RHOG GTPase cycle RAC3 GTPase cycle HCMV Early Events GPER1 signaling Potential therapeutics for SARS Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin Formation of the ureteric bud Mechanical load activates signaling by PIEZO1 and integrins in osteocytes Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells Developmental Lineage of Mammary Gland Luminal Epithelial Cells Developmental Lineage of Mammary Gland Myoepithelial Cells Developmental Lineage of Mammary Stem Cells	GAB1 signalosome VEGFA-VEGFR2 Pathway Smooth Muscle Contraction Localization of the PINCH-ILK-PARVIN complex to focal adhesions Regulation of cytoskeletal remodeling and cell spreading by IPP complex components PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition
Drugs		Antithymocyte immunoglobulin (rabbit) MK-0668 PLN-74809
Diseases
GWAS		Depression (quantitative trait) ( 20800221) Suicide in bipolar disorder ( 25917933)	Bipolar disorder ( 31043756) Left ventricle wall thickness ( 33495596) Left ventricular end-systolic volume ( 33495596) Left ventricular mass to end-diastolic volume ratio ( 33495596) Mean spheric corpuscular volume ( 32888494) Platelet count ( 29403010)
Interacting Genes		80 interacting genes: ACAP1 ACTN1 ACTN4 ARHGAP5 CANX CD151 CD274 CD36 CD46 CD82 CD9 CD93 COL18A1 CRKL DAG1 DOK1 EGFR ENO1 EPS8 FBLN1 FBXO2 FERMT1 FERMT2 FERMT3 FHL2 FLNA FLNB FLT4 FN1 HSPD1 HSPG2 ICAM4 IGF1R ILK ITGA1 ITGA10 ITGA11 ITGA2 ITGA3 ITGA4 ITGA5 ITGA6 ITGA8 ITGA9 ITGAV ITGB1BP1 ITGB1BP2 LAMA1 LAMTOR5 LGALS1 LGALS3BP LGALS8 MAP4K4 MET NCKIPSD NF2 NGF NME1 NMRK2 PDHB PIP5K1C PLAUR PRKCA PRKCE PTK2 PXN RAB25 RACK1 SLC3A2 SPP1 TGM2 TGOLN2 TIMP2 TLN1 TSPAN4 TSPAN7 UPF2 VCAM1 VCAN YWHAB	86 interacting genes: ABL1 ACO1 AHCY AR ARHGEF7 ASAP1 ASAP2 BCAR1 BCL2 BLK CASP3 CEACAM1 CLTC CREB3L2 CRK CRKL CSK DGUOK DPY30 EPHB1 FYN GART GIT1 GIT2 GRB2 GSK3A GSK3B GSN HDAC6 ILK ITGA4 ITGA6 ITGA9 ITGAV ITGB1 ITGB3 LCK LIMK1 LINC00632 LMO1 LMO3 MAPK1 MAPK3 MAPK8 MATK NCK1 NEDD9 NF2 PABPC1 PAK1 PAK3 PARVA PDPK1 PKD1 PLEKHH2 POLR1D PPP2CA PPP2R5C PTEN PTK2 PTK2B PTPN11 PTPN12 PTPRH RASA1 REPS2 RHOU RNF5 SDC4 SELE SH3RF1 SORBS1 SRC SYK TCEANC TGM2 TLN1 TRIM15 TRIP6 TUBA1B TUBA3C TUBA8 TUBG1 TUBG2 VCL WHRN
Entrez ID		3688	5829
HPRD ID		00628	03937
Ensembl ID		ENSG00000150093	ENSG00000089159
Uniprot IDs		P05556	A0A140VJQ8 A0A1B0GTU4 F5GZ78 P49023
PDB IDs		3G9W 3T9K 3VI3 3VI4 4DX9 4WJK 4WK0 4WK2 4WK4 7CEB 7CEC 7NWL 7NXD 8RPQ 8W30 9B9J 9B9K 9CKV	1OW6 1OW7 1OW8 2K2R 2O9V 2VZD 2VZG 2VZI 3GM1 3PY7 3RQE 3RQF 3RQG 3U3F 4EDN 4R32 4XGZ 4XH2 5UWH 6IUI 6PW8 6U4M 6U4N 7QB0
Enriched GO Terms of Interacting Partners?		Integrin Binding Focal Adhesion Cell Adhesion Integrin-mediated Signaling Pathway Cell-matrix Adhesion Cell-substrate Adhesion Regulation Of Cell Adhesion Positive Regulation Of Cell Adhesion Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Regulation Of Cell Migration Integrin Complex Regulation Of Cell Motility Regulation Of Locomotion Cell Surface Regulation Of Cell-substrate Adhesion Plasma Membrane Cell Migration Positive Regulation Of Cell-substrate Adhesion Cell-cell Adhesion Cell Surface Receptor Signaling Pathway Cell Motility Signal Transduction Regulation Of Cell Population Proliferation Regulation Of Cell Communication Regulation Of Signal Transduction Positive Regulation Of Cell Population Proliferation Anchoring Junction Regulation Of Signaling Regulation Of Intracellular Signal Transduction Regulation Of Programmed Cell Death Regulation Of Multicellular Organismal Process Extracellular Exosome Signaling Receptor Activity Substrate Adhesion-dependent Cell Spreading Regulation Of Apoptotic Process Membrane Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Cell Communication Cell-substrate Junction Assembly Anatomical Structure Morphogenesis Cell-substrate Junction Organization Integrin Activation Positive Regulation Of Signal Transduction Ruffle Membrane Regulation Of Cellular Component Organization Collagen Binding Involved In Cell-matrix Adhesion Positive Regulation Of Signaling Positive Regulation Of Cellular Component Organization	Focal Adhesion Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Cell Adhesion Integrin-mediated Signaling Pathway Cell Migration Regulation Of Cellular Component Organization Cell Surface Receptor Signaling Pathway Ephrin Receptor Signaling Pathway Anchoring Junction Cell Motility Regulation Of Cytoskeleton Organization Regulation Of Cell-substrate Adhesion Positive Regulation Of Cell Adhesion Regulation Of Cell Migration Regulation Of Intracellular Signal Transduction Cytosol Regulation Of Cell Motility Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Cell Migration Regulation Of Locomotion Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Immune Response-regulating Cell Surface Receptor Signaling Pathway ERBB Signaling Pathway Signal Transduction Immune Response-activating Cell Surface Receptor Signaling Pathway Non-membrane Spanning Protein Tyrosine Kinase Activity Phosphotyrosine Residue Binding Cell-substrate Adhesion Protein Kinase Activity Regulation Of Cell-matrix Adhesion Cell Projection Organization Regulation Of Immune System Process Lamellipodium Plasma Membrane Bounded Cell Projection Organization Positive Regulation Of Cellular Component Organization Regulation Of Signal Transduction Positive Regulation Of Intracellular Signal Transduction Cytoplasm Regulation Of MAPK Cascade Plasma Membrane Regulation Of Cellular Localization Regulation Of Protein Localization Immune Response-activating Signaling Pathway Immune Response-regulating Signaling Pathway Regulation Of Organelle Organization Kinase Activity Positive Regulation Of Immune System Process Fc-gamma Receptor Signaling Pathway
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