IFNGR1 and IFNGR2

Number of citations of the paper that reports this interaction (PMID 7673114)
21

Data Source:
HPRD (in vivo)

		IFNGR1	IFNGR2
Gene Name		interferon gamma receptor 1	interferon gamma receptor 2 (interferon gamma transducer 1)
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Endoplasmic Reticulum Plasma Membrane Integral Component Of Plasma Membrane Postsynaptic Density Integral Component Of Membrane Dendrite Vesicle	Endoplasmic Reticulum Plasma Membrane Integral Component Of Plasma Membrane Integral Component Of Membrane
	Molecular Function	Cytokine Receptor Activity Interferon-gamma Receptor Activity Protein Binding Cytokine Binding	Cytokine Receptor Activity Interferon-gamma Receptor Activity
	Biological Process	Signal Transduction Response To Virus Cytokine-mediated Signaling Pathway Interferon-gamma-mediated Signaling Pathway Regulation Of Interferon-gamma-mediated Signaling Pathway	Cell Surface Receptor Signaling Pathway Response To Virus Cytokine-mediated Signaling Pathway Interferon-gamma-mediated Signaling Pathway Regulation Of Interferon-gamma-mediated Signaling Pathway
Pathways		Interferon gamma signaling Interferon Signaling Cytokine Signaling in Immune system Regulation of IFNG signaling	Interferon gamma signaling Interferon Signaling Cytokine Signaling in Immune system Regulation of IFNG signaling
Drugs		Interferon gamma-1b	Interferon gamma-1b
Diseases
GWAS			Crohn's disease ( 22936669 23128233) Obesity-related traits ( 23251661)
Protein-Protein Interactions		10 interactors: CANX IFNG IFNGR2 JAK1 JAK2 PTPN11 RAC1 SOCS1 STAT1 STAT4	8 interactors: ANXA5 CAMK2D DNAJA3 IFNG IFNGR1 JAK2 NR3C1 RPL37A
Entrez ID		3459	3460
HPRD ID		00127	00956
Ensembl ID		ENSG00000027697	ENSG00000159128
Uniprot IDs		B4DFT7 F5H5M7 P15260	A8K881 E7EUY1 P38484
PDB IDs		1FG9 1FYH 1JRH
Enriched GO Terms of Interacting Partners?		Regulation Of Interferon-gamma-mediated Signaling Pathway Regulation Of Response To Interferon-gamma Regulation Of Cytokine-mediated Signaling Pathway Interferon-gamma-mediated Signaling Pathway Cellular Response To Interferon-gamma Response To Interferon-gamma Cytokine-mediated Signaling Pathway Regulation Of Innate Immune Response Cellular Response To Cytokine Stimulus Response To Cytokine Innate Immune Response Regulation Of Immune Response Cellular Response To Organic Substance Regulation Of Type I Interferon-mediated Signaling Pathway Immune Response Regulation Of Immune System Process Defense Response Immune System Process JAK-STAT Cascade Response To Organic Substance Type I Interferon Signaling Pathway Cellular Response To Type I Interferon JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Response To Type I Interferon Cell Surface Receptor Signaling Pathway Growth Hormone Receptor Signaling Pathway Cellular Response To Growth Hormone Stimulus Negative Regulation Of Metanephric Nephron Tubule Epithelial Cell Differentiation Negative Regulation Of Nephron Tubule Epithelial Cell Differentiation Response To Growth Hormone Enzyme Linked Receptor Protein Signaling Pathway Signaling Cell Communication Regulation Of Signal Transduction Intracellular Signal Transduction Negative Regulation Of Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Regulation Of Signaling Positive Regulation Of Cell Activation Cellular Response To Peptide Hormone Stimulus Regulation Of JAK-STAT Cascade Cellular Response To Peptide Response To Stress Regulation Of Metanephric Nephron Tubule Epithelial Cell Differentiation Regulation Of Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Signal Transduction Regulation Of Cell-cell Adhesion Positive Regulation Of Cell Adhesion Cell Migration Cell Motility	Regulation Of Interferon-gamma-mediated Signaling Pathway Regulation Of Response To Interferon-gamma Response To Interferon-gamma Regulation Of Cytokine-mediated Signaling Pathway Interferon-gamma-mediated Signaling Pathway Cellular Response To Interferon-gamma Regulation Of Innate Immune Response Response To Organic Substance Response To Cytokine Innate Immune Response Cytokine-mediated Signaling Pathway Regulation Of Heart Contraction Cellular Response To Cytokine Stimulus Immune Response Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Defense Response Positive Regulation Of Cell Death Positive Regulation Of Interleukin-1 Beta Production Regulation Of Apoptotic Process Positive Regulation Of Phosphatase Activity Regulation Of The Force Of Heart Contraction Positive Regulation Of Interleukin-1 Production Regulation Of Cell Death Homeostasis Of Number Of Cells Regulation Of Signal Transduction Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Cell Proliferation Positive Regulation Of Reactive Oxygen Species Biosynthetic Process Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Positive Regulation Of Proteolysis Positive Regulation Of Cell Activation Regulation Of Signaling Regulation Of Immune Response Positive Regulation Of Dephosphorylation Regulation Of Interleukin-1 Beta Production Regulation Of Transcription From RNA Polymerase II Promoter Cellular Response To Organic Substance Positive Regulation Of Tumor Necrosis Factor Production Establishment Of Protein Localization To Organelle Signal Transduction Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of JAK-STAT Cascade Regulation Of Cell-cell Adhesion Positive Regulation Of Cell Adhesion Regulation Of Reactive Oxygen Species Biosynthetic Process Response To Stress Regulation Of Steroid Biosynthetic Process Intracellular Steroid Hormone Receptor Signaling Pathway Signaling
Tagcloud ?		30min ancestry asks asleep habitual il10 il13 il17a il1b il1r2 il2 il4 il6 il8 interleukins nfkb1 nfkb2 pittsburgh rs1143623 rs1143642 rs1295686 rs2857602 rs4648110 rs4719714 soi strengthens tnfa transgender	allelic candidiasis cybb definition designation errors il12b il12rb1 immunological impair inborn intramacrophagic irf8 isg15 mendelian msmd mycobacteria nemo overt parasites penetrance perhaps physiologically predisposition recapitulate salmonellosis virulent weakly
Tagcloud (Difference) ?		30min ancestry asks asleep habitual il10 il13 il17a il1b il1r2 il2 il4 il6 il8 interleukins nfkb1 nfkb2 pittsburgh rs1143623 rs1143642 rs1295686 rs2857602 rs4648110 rs4719714 soi strengthens tnfa transgender	allelic candidiasis cybb definition designation errors il12b il12rb1 immunological impair inborn intramacrophagic irf8 isg15 mendelian msmd mycobacteria nemo overt parasites penetrance perhaps physiologically predisposition recapitulate salmonellosis virulent weakly
Tagcloud (Intersection) ?