IFNGR1 and RUSF1

Number of citations of the paper that reports this interaction (PubMedID 28514442)
50

Data Source:
BioGRID (affinity chromatography technology, two hybrid)

		IFNGR1	RUSF1
Description		interferon gamma receptor 1	RUS family member 1
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane	Membrane
	Molecular Function	Cytokine Receptor Activity Type II Interferon Receptor Activity Protein Binding Cytokine Binding	Protein Binding
	Biological Process	Microglial Cell Activation Immune System Process Signal Transduction Cell Surface Receptor Signaling Pathway Via JAK-STAT Response To Virus Positive Regulation Of Gene Expression Cytokine-mediated Signaling Pathway Positive Regulation Of Tumor Necrosis Factor Production Type III Interferon-mediated Signaling Pathway Astrocyte Activation Defense Response To Virus Type II Interferon-mediated Signaling Pathway Defense Response To Other Organism Cellular Response To Virus Negative Regulation Of Amyloid-beta Clearance Positive Regulation Of Amyloid-beta Formation
Pathways		Interferon gamma signaling Regulation of IFNG signaling Regulation of IFNG signaling Potential therapeutics for SARS IFNG signaling activates MAPKs
Drugs		Interferon gamma-1b
Diseases		Tuberculosis IFN-gamma/IL-12 axis, including the following five diseases: IL-12 p40 subunit deficiency; IL-12 receptor (IL-12R) beta1 chain deficiency; IFN-gamma receptor (IFN gamma R) alpha chain deficiency; IFN-gamma receptor (IFN gamma R) beta chain deficiency; STAT-1 deficiency
GWAS		Behcet's disease ( 33393726) BMI (adjusted for smoking behaviour) ( 28443625) Body mass index ( 25673413) Body mass index (joint analysis main effects and smoking interaction) ( 28443625) Cognitive decline rate in late mild cognitive impairment ( 26252872) Cognitive performance (processing speed) ( 31598132)
Interacting Genes		15 interacting genes: AQP6 CANX IFNG IFNGR2 JAK1 JAK2 NINJ2 PTPN11 RAC1 RUSF1 SOCS1 STAT1 STIM1 TMEM100 TMEM237	53 interacting genes: AQP6 ARL13B ARL6IP6 BIK C5orf46 CISD2 CMTM5 CREB3 CREB3L1 CREB3L3 DGAT2L6 DHRSX EBP EHHADH ERGIC3 FAM209A FCER1G FFAR2 FKBP7 GJA8 GPR42 HSD17B13 IFNGR1 IL10RA ITGAM LHFPL5 LMNA MMGT1 MS4A4A ODF4 PDCD1LG2 PGRMC2 PSCA PVR RETREG3 RNF5 SCN3B SFXN3 SLC10A1 SLC10A6 SLC30A8 SLC35E3 SLC35H1 SPAG4 SSMEM1 TEX29 TMEM237 TMEM248 TMEM35A TMX2 UBE2I ZCCHC12 ZDHHC15
Entrez ID		3459	64755
HPRD ID		00127	07839
Ensembl ID		ENSG00000027697	ENSG00000140688
Uniprot IDs		A0A0S2Z3Y2 A0A2R8Y4U4 A0A2R8YFL3 P15260	Q96GQ5
PDB IDs		1FG9 1FYH 1JRH 6E3K 6E3L
Enriched GO Terms of Interacting Partners?		Type II Interferon-mediated Signaling Pathway Interferon-mediated Signaling Pathway Cell Surface Receptor Signaling Pathway Via JAK-STAT Cell Surface Receptor Signaling Pathway Via STAT Cytokine-mediated Signaling Pathway Type III Interferon-mediated Signaling Pathway Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Nitric Oxide Metabolic Process Regulation Of Receptor Signaling Pathway Via JAK-STAT Cellular Response To Virus Positive Regulation Of Developmental Process Cell Surface Receptor Signaling Pathway Microglial Cell Activation Positive Regulation Of Cell Adhesion Leukocyte Activation Involved In Inflammatory Response Positive Regulation Of Nitric Oxide Biosynthetic Process Myeloid Leukocyte Activation Positive Regulation Of Nitric Oxide Metabolic Process Positive Regulation Of Cell-cell Adhesion Regulation Of Developmental Process Regulation Of Epithelial Cell Differentiation Regulation Of Insulin Secretion Regulation Of Multicellular Organismal Development Enzyme-linked Receptor Protein Signaling Pathway Response To Virus Interleukin-9-mediated Signaling Pathway CCR5 Chemokine Receptor Binding Interleukin-7-mediated Signaling Pathway Macrophage Activation Regulation Of Peptide Hormone Secretion Regulation Of Cell Differentiation Positive Regulation Of Glutamate Receptor Signaling Pathway Regulation Of Interleukin-23 Production Growth Hormone Receptor Binding Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Alpha-beta T Cell Activation Peptide Hormone Receptor Binding Interleukin-2-mediated Signaling Pathway Regulation Of Glutamate Receptor Signaling Pathway Regulation Of Cell Adhesion Regulation Of Cytokine Production Regulation Of Multicellular Organismal Process Positive Regulation Of Transport Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Myeloid Cell Differentiation Regulation Of Cell-cell Adhesion Regulation Of Hormone Secretion Cell Differentiation Positive Regulation Of MHC Class II Biosynthetic Process	Membrane Endoplasmic Reticulum Protein Binding Positive Regulation Of Acute Inflammatory Response Endoplasmic Reticulum Membrane Bile Acid:sodium Symporter Activity Acetylcholine Receptor Regulator Activity
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