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CDC42 and ARHGEF7
Number of citations of the paper that reports this interaction (PMID
14505571
)
43
Data Source:
BioGRID
(affinity chromatography technology, pull down)
HPRD
(in vitro)
CDC42
ARHGEF7
Gene Name
cell division cycle 42
Rho guanine nucleotide exchange factor (GEF) 7
Image
Gene Ontology Annotations
Cellular Component
Golgi Membrane
Cytoplasm
Microtubule Organizing Center
Cytosol
Plasma Membrane
Cell-cell Junction
Focal Adhesion
Membrane
Secretory Granule
Filopodium
Midbody
Leading Edge Membrane
Cytoplasmic Ribonucleoprotein Granule
Neuron Projection
Neuronal Cell Body
Apical Part Of Cell
Spindle Midzone
Extracellular Vesicular Exosome
Mitotic Spindle
Ruffle
Cytosol
Focal Adhesion
Cell Cortex
Lamellipodium
Neuron Projection
Neuronal Cell Body
Protein Complex
Molecular Function
GTPase Activity
Protein Binding
GTP Binding
Protein Kinase Binding
GTP-dependent Protein Binding
Mitogen-activated Protein Kinase Kinase Kinase Binding
Thioesterase Binding
Apolipoprotein A-I Receptor Binding
Identical Protein Binding
Guanyl-nucleotide Exchange Factor Activity
Rho Guanyl-nucleotide Exchange Factor Activity
Protein Binding
Protein Kinase Binding
Biological Process
Sprouting Angiogenesis
Cardiac Conduction System Development
Keratinocyte Development
Golgi Organization
Regulation Of Mitotic Nuclear Division
Nuclear Migration
Establishment Or Maintenance Of Cell Polarity
Epidermal Growth Factor Receptor Signaling Pathway
Small GTPase Mediated Signal Transduction
Axon Guidance
Blood Coagulation
Metabolic Process
Positive Regulation Of Gene Expression
Negative Regulation Of Gene Expression
Substantia Nigra Development
Actin Cytoskeleton Organization
Macrophage Differentiation
Hair Follicle Morphogenesis
Positive Regulation Of Pseudopodium Assembly
T Cell Costimulation
Negative Regulation Of Protein Complex Assembly
Keratinization
Regulation Of Protein Stability
Positive Regulation Of Cytokinesis
Positive Regulation Of Peptidyl-serine Phosphorylation
Adherens Junction Organization
Cellular Protein Localization
Establishment Or Maintenance Of Apical/basal Cell Polarity
Multicellular Organism Growth
Dendritic Cell Migration
Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis
Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
Regulation Of Protein Catabolic Process
Muscle Cell Differentiation
Regulation Of Protein Heterodimerization Activity
Positive Regulation Of Neuron Apoptotic Process
Positive Regulation Of Phosphatidylinositol 3-kinase Activity
Innate Immune Response
Positive Regulation Of DNA Replication
Regulation Of Protein Kinase Activity
Positive Regulation Of JNK Cascade
Filopodium Assembly
Vascular Endothelial Growth Factor Receptor Signaling Pathway
Ephrin Receptor Signaling Pathway
Positive Regulation Of Metalloenzyme Activity
Neuron Fate Determination
Actin Filament Bundle Assembly
Regulation Of Small GTPase Mediated Signal Transduction
Positive Regulation Of Muscle Cell Differentiation
Regulation Of Filopodium Assembly
Establishment Of Golgi Localization
Positive Regulation Of Synapse Structural Plasticity
Regulation Of Attachment Of Spindle Microtubules To Kinetochore
Heart Contraction
Canonical Wnt Signaling Pathway
Submandibular Salivary Gland Formation
Epithelial-mesenchymal Cell Signaling
Hair Follicle Placode Formation
Positive Regulation Of Hair Follicle Cell Proliferation
Organelle Transport Along Microtubule
Actin Filament Branching
Epithelial Cell-cell Adhesion
Positive Regulation Of Intracellular Protein Transport
Positive Regulation Of Substrate Adhesion-dependent Cell Spreading
Hematopoietic Progenitor Cell Differentiation
Signal Transduction
Epidermal Growth Factor Receptor Signaling Pathway
Small GTPase Mediated Signal Transduction
Axon Guidance
Positive Regulation Of Fibroblast Migration
Lamellipodium Assembly
Positive Regulation Of Rac GTPase Activity
Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
Positive Regulation Of Apoptotic Process
Positive Regulation Of GTPase Activity
Neurotrophin TRK Receptor Signaling Pathway
Ephrin Receptor Signaling Pathway
Focal Adhesion Assembly
Regulation Of Small GTPase Mediated Signal Transduction
Apoptotic Signaling Pathway
Positive Regulation Of Substrate Adhesion-dependent Cell Spreading
Positive Regulation Of Lamellipodium Morphogenesis
Pathways
Signaling by GPCR
Costimulation by the CD28 family
Axon guidance
DCC mediated attractive signaling
Signaling by EGFRvIII in Cancer
VEGFA-VEGFR2 Pathway
Inactivation of Cdc42 and Rac
Rho GTPase cycle
EPHB-mediated forward signaling
EPH-Ephrin signaling
G alpha (12/13) signalling events
Sema4D in semaphorin signaling
Netrin-1 signaling
Fcgamma receptor (FCGR) dependent phagocytosis
Sema4D induced cell migration and growth-cone collapse
Regulation of actin dynamics for phagocytic cup formation
Innate Immune System
EGFR downregulation
CDO in myogenesis
Semaphorin interactions
CD28 co-stimulation
Signaling by Ligand-Responsive EGFR Variants in Cancer
Factors involved in megakaryocyte development and platelet production
Signaling by Overexpressed Wild-Type EGFR in Cancer
CD28 dependent Vav1 pathway
Signaling by EGFR
GPCR downstream signaling
Myogenesis
Signaling by VEGF
Signaling by Rho GTPases
Signaling by EGFR in Cancer
GPVI-mediated activation cascade
Platelet activation, signaling and aggregation
Signaling by Robo receptor
Adaptive Immune System
EGFR downregulation
Signaling by GPCR
Signalling by NGF
Axon guidance
Cell death signalling via NRAGE, NRIF and NADE
Signaling by Ligand-Responsive EGFR Variants in Cancer
p75 NTR receptor-mediated signalling
Signaling by Overexpressed Wild-Type EGFR in Cancer
Signaling by EGFRvIII in Cancer
Rho GTPase cycle
Signaling by EGFR
GPCR downstream signaling
Ephrin signaling
NRAGE signals death through JNK
Signaling by Rho GTPases
Signaling by EGFR in Cancer
EPH-Ephrin signaling
G alpha (12/13) signalling events
Drugs
Diseases
GWAS
Immune response to smallpox vaccine (IL-6) (
22610502
)
Bilirubin levels (
19414484
)
Menarche (age at onset) (
21102462
)
Menopause (age at onset) (
19448619
)
Protein-Protein Interactions
144 interactors:
A2M
ACTR3
AHSG
ANXA2
APOH
ARHGAP1
ARHGAP10
ARHGAP17
ARHGAP26
ARHGAP27
ARHGAP29
ARHGAP31
ARHGAP32
ARHGAP44
ARHGDIA
ARHGDIB
ARHGDIG
ARHGEF11
ARHGEF25
ARHGEF6
ARHGEF7
ARRB1
ARRB2
BAIAP2
BCR
BNIP2
BNIPL
C14orf1
CASP3
CASP7
CBLL1
CDC42BPA
CDC42BPB
CDC42BPG
CDC42EP1
CDC42EP2
CDC42EP3
CDC42EP4
CDC42EP5
CDC42SE1
CDC42SE2
CDH1
CDKN1A
CFHR4
CNTNAP1
COX1
CPN1
CSN2
CSPG4
DEF6
DIAPH2
DIAPH3
DOCK7
DOCK8
DOCK9
EEF1G
EIF2AK2
ERRFI1
ETFA
FGD1
FGD3
FLNA
FMNL2
FNBP1
GDI1
GOPC
GRB2
HERC2
IQGAP1
IQGAP2
ITSN1
KAT5
KIAA2026
KTN1
LCK
LGALS1
LRIF1
MAP3K10
MAP3K11
MAP3K4
MARK4
MCF2
MCF2L
MCM3AP
METAP2
MUC12
MYO6
MYO9A
NCF2
NEK6
OCRL
OPHN1
PAK1
PAK2
PAK3
PAK4
PAK6
PAK7
PARD3
PARD6A
PARD6B
PARD6G
PDE6D
PGGT1B
PIK3R1
PLD1
PLEKHG2
PRKCA
PRKCG
PRKCI
PRKCZ
RAC1
RAC2
RAP1GDS1
RHOJ
RIOK3
RPL22
RPL23
RPS6KB1
S100A9
SH3D19
SRGAP1
SSX2IP
ST13
STAU1
SYNE1
TBC1D3F
TNK2
TP53
TRAF2
TRIP10
UBR1
UNC119
USP6
VAV1
VRK2
WAS
WASF1
WASF2
WASL
WIPF1
ZNF175
ZNF234
ZNF420
28 interactors:
ADAM15
ARHGEF6
CALM1
CBLB
CD244
CDC42
ERBB2IP
GIT1
GIT2
LRRK2
MEOX2
NCK1
NCKIPSD
PAK1
PAK2
PAK3
PPM1E
PPM1F
PXN
RAC1
SCRIB
SH2D1A
SHANK1
SHANK2
TGFBR2
TUBB3
WAS
YWHAG
Entrez ID
998
8874
HPRD ID
00309
05688
Ensembl ID
ENSG00000070831
ENSG00000102606
Uniprot IDs
B4E1U9
E7ETU3
P60953
B7Z6G2
E9PDQ5
Q14155
PDB IDs
1A4R
1AJE
1AM4
1AN0
1CEE
1CF4
1DOA
1E0A
1EES
1GRN
1GZS
1KI1
1KZ7
1KZG
1NF3
2ASE
2DFK
2KB0
2NGR
2ODB
2QRZ
2WM9
2WMN
2WMO
3GCG
3QBV
3VHL
4DID
4ITR
1BY1
1ZSG
2L3G
Enriched GO Terms of Interacting Partners
?
Regulation Of Catalytic Activity
Intracellular Signal Transduction
Positive Regulation Of Catalytic Activity
Regulation Of Intracellular Signal Transduction
Small GTPase Mediated Signal Transduction
Regulation Of Small GTPase Mediated Signal Transduction
Positive Regulation Of Hydrolase Activity
Regulation Of Signal Transduction
Regulation Of Signaling
Positive Regulation Of GTPase Activity
Regulation Of GTPase Activity
Signal Transduction
Positive Regulation Of Rho GTPase Activity
Positive Regulation Of Metabolic Process
Signaling
Regulation Of Rho Protein Signal Transduction
Regulation Of Rho GTPase Activity
Cell Communication
Positive Regulation Of Ras GTPase Activity
Cytoskeleton Organization
Cellular Response To Stimulus
Regulation Of Ras Protein Signal Transduction
Response To Stimulus
Regulation Of Ras GTPase Activity
Actin Filament-based Process
Actin Cytoskeleton Organization
Regulation Of Metabolic Process
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Enzyme Linked Receptor Protein Signaling Pathway
Regulation Of Cellular Component Organization
Regulation Of Cellular Process
Ras Protein Signal Transduction
Neurotrophin TRK Receptor Signaling Pathway
Apoptotic Process
Cell Death
Death
Neurotrophin Signaling Pathway
Programmed Cell Death
Rho Protein Signal Transduction
Movement Of Cell Or Subcellular Component
Regulation Of Apoptotic Process
Cellular Response To Growth Factor Stimulus
Regulation Of Cell Death
Response To Growth Factor
Organelle Organization
Positive Regulation Of Programmed Cell Death
Positive Regulation Of Cell Death
Endocytosis
Locomotion
Positive Regulation Of Apoptotic Process
Vascular Endothelial Growth Factor Receptor Signaling Pathway
Regulation Of Kinase Activity
Regulation Of Catalytic Activity
Cell Morphogenesis Involved In Differentiation
Regulation Of Protein Kinase Activity
Regulation Of Signaling
Cell Morphogenesis
Regulation Of Protein Phosphorylation
Regulation Of Signal Transduction
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Signaling
Cell Projection Organization
Enzyme Linked Receptor Protein Signaling Pathway
Response To Stimulus
Cell Communication
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Positive Regulation Of Catalytic Activity
Regulation Of Phosphorylation
Fc Receptor Signaling Pathway
Cell Morphogenesis Involved In Neuron Differentiation
Positive Regulation Of Programmed Cell Death
Immune Response-activating Cell Surface Receptor Signaling Pathway
Positive Regulation Of Cell Death
Regulation Of Cell Adhesion
Regulation Of T Cell Activation
Neuron Projection Morphogenesis
Immune Response-regulating Signaling Pathway
Positive Regulation Of Immune System Process
Regulation Of Organelle Organization
Positive Regulation Of Kinase Activity
Regulation Of Phosphorus Metabolic Process
Cell Development
Movement Of Cell Or Subcellular Component
Regulation Of Cytoskeleton Organization
Positive Regulation Of T Cell Activation
Neuron Development
Positive Regulation Of Protein Metabolic Process
Positive Regulation Of Homotypic Cell-cell Adhesion
Regulation Of Actin Cytoskeleton Organization
Nervous System Development
Regulation Of Cell-cell Adhesion
Positive Regulation Of Cell Adhesion
Regulation Of Immune System Process
Positive Regulation Of Transferase Activity
Axon Guidance
Regulation Of Lymphocyte Activation
Positive Regulation Of Cell-cell Adhesion
Anatomical Structure Morphogenesis
Regulation Of Actin Filament-based Process
Neuron Projection Development
Tagcloud
?
abolished
adapter
adjacent
autophosphorylation
coprecipitate
coprecipitation
detailed
explained
fragment
gtpase
hck
homology
identity
modeling
mutational
nak
nck
nef
p21
pak
paks
plasmon
resonance
sh3
src
subset
termed
threonine
uncertain
Tagcloud (Difference)
?
abolished
adapter
adjacent
autophosphorylation
coprecipitate
coprecipitation
detailed
explained
fragment
gtpase
hck
homology
identity
modeling
mutational
nak
nck
nef
p21
pak
paks
plasmon
resonance
sh3
src
subset
termed
threonine
uncertain
Tagcloud (Intersection)
?