CDC42 and VRK2

Number of citations of the paper that reports this interaction (PMID 20936779)
48

Data Source:
BioGRID (two hybrid)

		CDC42	VRK2
Gene Name		cell division cycle 42	vaccinia related kinase 2
Image
Gene Ontology Annotations	Cellular Component	Golgi Membrane Cytoplasm Microtubule Organizing Center Cytosol Plasma Membrane Cell-cell Junction Focal Adhesion Membrane Secretory Granule Filopodium Midbody Leading Edge Membrane Cytoplasmic Ribonucleoprotein Granule Neuron Projection Neuronal Cell Body Apical Part Of Cell Spindle Midzone Extracellular Vesicular Exosome Mitotic Spindle	Nucleus Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Integral Component Of Membrane Mitochondrial Membrane
	Molecular Function	GTPase Activity Protein Binding GTP Binding Protein Kinase Binding GTP-dependent Protein Binding Mitogen-activated Protein Kinase Kinase Kinase Binding Thioesterase Binding Apolipoprotein A-I Receptor Binding Identical Protein Binding	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding
	Biological Process	Sprouting Angiogenesis Cardiac Conduction System Development Keratinocyte Development Golgi Organization Regulation Of Mitotic Nuclear Division Nuclear Migration Establishment Or Maintenance Of Cell Polarity Epidermal Growth Factor Receptor Signaling Pathway Small GTPase Mediated Signal Transduction Axon Guidance Blood Coagulation Metabolic Process Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Substantia Nigra Development Actin Cytoskeleton Organization Macrophage Differentiation Hair Follicle Morphogenesis Positive Regulation Of Pseudopodium Assembly T Cell Costimulation Negative Regulation Of Protein Complex Assembly Keratinization Regulation Of Protein Stability Positive Regulation Of Cytokinesis Positive Regulation Of Peptidyl-serine Phosphorylation Adherens Junction Organization Cellular Protein Localization Establishment Or Maintenance Of Apical/basal Cell Polarity Multicellular Organism Growth Dendritic Cell Migration Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Protein Catabolic Process Muscle Cell Differentiation Regulation Of Protein Heterodimerization Activity Positive Regulation Of Neuron Apoptotic Process Positive Regulation Of Phosphatidylinositol 3-kinase Activity Innate Immune Response Positive Regulation Of DNA Replication Regulation Of Protein Kinase Activity Positive Regulation Of JNK Cascade Filopodium Assembly Vascular Endothelial Growth Factor Receptor Signaling Pathway Ephrin Receptor Signaling Pathway Positive Regulation Of Metalloenzyme Activity Neuron Fate Determination Actin Filament Bundle Assembly Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of Muscle Cell Differentiation Regulation Of Filopodium Assembly Establishment Of Golgi Localization Positive Regulation Of Synapse Structural Plasticity Regulation Of Attachment Of Spindle Microtubules To Kinetochore Heart Contraction Canonical Wnt Signaling Pathway Submandibular Salivary Gland Formation Epithelial-mesenchymal Cell Signaling Hair Follicle Placode Formation Positive Regulation Of Hair Follicle Cell Proliferation Organelle Transport Along Microtubule Actin Filament Branching Epithelial Cell-cell Adhesion Positive Regulation Of Intracellular Protein Transport Positive Regulation Of Substrate Adhesion-dependent Cell Spreading	Protein Phosphorylation Endocytosis Regulation Of Cell Shape Viral Process Wnt Signaling Pathway Peptidyl-serine Phosphorylation Cellular Response To Oxidative Stress Regulation Of MAPK Cascade Protein Autophosphorylation Regulation Of Interleukin-1-mediated Signaling Pathway
Pathways		Signaling by GPCR Costimulation by the CD28 family Axon guidance DCC mediated attractive signaling Signaling by EGFRvIII in Cancer VEGFA-VEGFR2 Pathway Inactivation of Cdc42 and Rac Rho GTPase cycle EPHB-mediated forward signaling EPH-Ephrin signaling G alpha (12/13) signalling events Sema4D in semaphorin signaling Netrin-1 signaling Fcgamma receptor (FCGR) dependent phagocytosis Sema4D induced cell migration and growth-cone collapse Regulation of actin dynamics for phagocytic cup formation Innate Immune System EGFR downregulation CDO in myogenesis Semaphorin interactions CD28 co-stimulation Signaling by Ligand-Responsive EGFR Variants in Cancer Factors involved in megakaryocyte development and platelet production Signaling by Overexpressed Wild-Type EGFR in Cancer CD28 dependent Vav1 pathway Signaling by EGFR GPCR downstream signaling Myogenesis Signaling by VEGF Signaling by Rho GTPases Signaling by EGFR in Cancer GPVI-mediated activation cascade Platelet activation, signaling and aggregation Signaling by Robo receptor Adaptive Immune System
Drugs
Diseases
GWAS		Immune response to smallpox vaccine (IL-6) ( 22610502)	Schizophrenia ( 19571808)
Protein-Protein Interactions		144 interactors: A2M ACTR3 AHSG ANXA2 APOH ARHGAP1 ARHGAP10 ARHGAP17 ARHGAP26 ARHGAP27 ARHGAP29 ARHGAP31 ARHGAP32 ARHGAP44 ARHGDIA ARHGDIB ARHGDIG ARHGEF11 ARHGEF25 ARHGEF6 ARHGEF7 ARRB1 ARRB2 BAIAP2 BCR BNIP2 BNIPL C14orf1 CASP3 CASP7 CBLL1 CDC42BPA CDC42BPB CDC42BPG CDC42EP1 CDC42EP2 CDC42EP3 CDC42EP4 CDC42EP5 CDC42SE1 CDC42SE2 CDH1 CDKN1A CFHR4 CNTNAP1 COX1 CPN1 CSN2 CSPG4 DEF6 DIAPH2 DIAPH3 DOCK7 DOCK8 DOCK9 EEF1G EIF2AK2 ERRFI1 ETFA FGD1 FGD3 FLNA FMNL2 FNBP1 GDI1 GOPC GRB2 HERC2 IQGAP1 IQGAP2 ITSN1 KAT5 KIAA2026 KTN1 LCK LGALS1 LRIF1 MAP3K10 MAP3K11 MAP3K4 MARK4 MCF2 MCF2L MCM3AP METAP2 MUC12 MYO6 MYO9A NCF2 NEK6 OCRL OPHN1 PAK1 PAK2 PAK3 PAK4 PAK6 PAK7 PARD3 PARD6A PARD6B PARD6G PDE6D PGGT1B PIK3R1 PLD1 PLEKHG2 PRKCA PRKCG PRKCI PRKCZ RAC1 RAC2 RAP1GDS1 RHOJ RIOK3 RPL22 RPL23 RPS6KB1 S100A9 SH3D19 SRGAP1 SSX2IP ST13 STAU1 SYNE1 TBC1D3F TNK2 TP53 TRAF2 TRIP10 UBR1 UNC119 USP6 VAV1 VRK2 WAS WASF1 WASF2 WASL WIPF1 ZNF175 ZNF234 ZNF420	10 interactors: CCT2 CCT4 CDC42 LNX1 MAP2K7 MAP3K7 MAPK8IP1 MAPK8IP2 RBX1 TCP1
Entrez ID		998	7444
HPRD ID		00309	03702
Ensembl ID		ENSG00000070831	ENSG00000028116
Uniprot IDs		B4E1U9 E7ETU3 P60953	Q86Y07
PDB IDs		1A4R 1AJE 1AM4 1AN0 1CEE 1CF4 1DOA 1E0A 1EES 1GRN 1GZS 1KI1 1KZ7 1KZG 1NF3 2ASE 2DFK 2KB0 2NGR 2ODB 2QRZ 2WM9 2WMN 2WMO 3GCG 3QBV 3VHL 4DID 4ITR	2V62
Enriched GO Terms of Interacting Partners?		Regulation Of Catalytic Activity Intracellular Signal Transduction Positive Regulation Of Catalytic Activity Regulation Of Intracellular Signal Transduction Small GTPase Mediated Signal Transduction Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of Hydrolase Activity Regulation Of Signal Transduction Regulation Of Signaling Positive Regulation Of GTPase Activity Regulation Of GTPase Activity Signal Transduction Positive Regulation Of Rho GTPase Activity Positive Regulation Of Metabolic Process Signaling Regulation Of Rho Protein Signal Transduction Regulation Of Rho GTPase Activity Cell Communication Positive Regulation Of Ras GTPase Activity Cytoskeleton Organization Cellular Response To Stimulus Regulation Of Ras Protein Signal Transduction Response To Stimulus Regulation Of Ras GTPase Activity Actin Filament-based Process Actin Cytoskeleton Organization Regulation Of Metabolic Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Cellular Component Organization Regulation Of Cellular Process Ras Protein Signal Transduction Neurotrophin TRK Receptor Signaling Pathway Apoptotic Process Cell Death Death Neurotrophin Signaling Pathway Programmed Cell Death Rho Protein Signal Transduction Movement Of Cell Or Subcellular Component Regulation Of Apoptotic Process Cellular Response To Growth Factor Stimulus Regulation Of Cell Death Response To Growth Factor Organelle Organization Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Endocytosis Locomotion Positive Regulation Of Apoptotic Process	Regulation Of JNK Cascade Regulation Of Stress-activated MAPK Cascade JNK Cascade Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Positive Regulation Of Stress-activated MAPK Cascade Positive Regulation Of Stress-activated Protein Kinase Signaling Cascade Toxin Transport Binding Of Sperm To Zona Pellucida Sperm-egg Recognition 'de Novo' Posttranslational Protein Folding MAPK Cascade 'de Novo' Protein Folding Cell-cell Recognition Regulation Of MAPK Cascade Signal Transduction By Phosphorylation Regulation Of JUN Kinase Activity Regulation Of Protein Kinase Activity Regulation Of Kinase Activity Cell Recognition Positive Regulation Of JNK Cascade Single Fertilization Positive Regulation Of MAPK Cascade Positive Regulation Of Kinase Activity Regulation Of Protein Phosphorylation Cellular Protein Metabolic Process Fertilization Positive Regulation Of Transferase Activity Positive Regulation Of Signal Transduction Regulation Of Phosphorylation Positive Regulation Of Protein Phosphorylation Fc Receptor Signaling Pathway Regulation Of Apoptotic Process Regulation Of Phosphorus Metabolic Process Protein Folding Cellular Response To Stress Regulation Of MAP Kinase Activity Sexual Reproduction Regulation Of Cell Death Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Protein Metabolic Process Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Positive Regulation Of Neuron Apoptotic Process Positive Regulation Of Phosphorylation TRIF-dependent Toll-like Receptor Signaling Pathway
Tagcloud ?		abolished adapter adjacent autophosphorylation coprecipitate coprecipitation detailed explained fragment gtpase hck homology identity modeling mutational nak nck nef p21 pak paks plasmon resonance sh3 src subset termed threonine uncertain	2p16 2q24 4p15 agencies assisting epilepsies epilepsy ethnically fancl filtering generalised governmental grouping harbouring heritability ie implicating imputation league lumping pcdh7 phenotyped philanthropic pleiotropically protocadherin scn1a splitting standardised unclassified
Tagcloud (Difference) ?		abolished adapter adjacent autophosphorylation coprecipitate coprecipitation detailed explained fragment gtpase hck homology identity modeling mutational nak nck nef p21 pak paks plasmon resonance sh3 src subset termed threonine uncertain	2p16 2q24 4p15 agencies assisting epilepsies epilepsy ethnically fancl filtering generalised governmental grouping harbouring heritability ie implicating imputation league lumping pcdh7 phenotyped philanthropic pleiotropically protocadherin scn1a splitting standardised unclassified
Tagcloud (Intersection) ?