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CDC42 and STAT1
Number of citations of the paper that reports this interaction (PubMedID
31478661
)
0
Data Source:
BioGRID
(pull down)
CDC42
STAT1
Description
cell division cycle 42
signal transducer and activator of transcription 1
Image
GO Annotations
Cellular Component
Golgi Membrane
Storage Vacuole
Cytoplasm
Endoplasmic Reticulum Membrane
Centrosome
Spindle
Cytosol
Cytoskeleton
Plasma Membrane
Cell-cell Junction
Focal Adhesion
Membrane
Golgi Transport Complex
Filopodium
Dendrite
Midbody
Cell Leading Edge
Leading Edge Membrane
Protein-containing Complex
Cytoplasmic Ribonucleoprotein Granule
Cell Projection
Neuron Projection
Neuronal Cell Body
Apical Part Of Cell
Phagocytic Vesicle
Spindle Midzone
Extracellular Exosome
Cell Periphery
Mitotic Spindle
Postsynapse
Glutamatergic Synapse
Chromatin
Nucleus
Nucleoplasm
Nucleolus
Cytoplasm
Cytosol
Axon
Dendrite
Protein-containing Complex
Perinuclear Region Of Cytoplasm
ISGF3 Complex
RNA Polymerase II Transcription Regulator Complex
Molecular Function
Nucleotide Binding
GTPase Activity
G Protein Activity
Protein Binding
GTP Binding
Hydrolase Activity
Protein Kinase Binding
GTP-dependent Protein Binding
Thioesterase Binding
GBD Domain Binding
Apolipoprotein A-I Receptor Binding
Identical Protein Binding
Ubiquitin Protein Ligase Activity
RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Core Promoter Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
Transcription Corepressor Binding
Transcription Coactivator Binding
DNA Binding
Double-stranded DNA Binding
DNA-binding Transcription Factor Activity
Tumor Necrosis Factor Receptor Binding
Protein Binding
Enzyme Binding
CCR5 Chemokine Receptor Binding
Histone Acetyltransferase Binding
Histone Binding
Identical Protein Binding
Protein Homodimerization Activity
Sequence-specific DNA Binding
Ubiquitin-like Protein Ligase Binding
Cadherin Binding
Protein Phosphatase 2A Binding
Promoter-specific Chromatin Binding
Biological Process
Heart Process
Cardiac Conduction System Development
Cardiac Neural Crest Cell Migration Involved In Outflow Tract Morphogenesis
Endocytosis
Phagocytosis, Engulfment
Actin Filament Organization
Golgi Organization
Regulation Of Mitotic Nuclear Division
Nuclear Migration
Establishment Or Maintenance Of Cell Polarity
Signal Transduction
Integrin-mediated Signaling Pathway
Small GTPase-mediated Signal Transduction
Nervous System Development
Intracellular Protein Localization
Anatomical Structure Morphogenesis
Regulation Of Lamellipodium Assembly
Positive Regulation Of Lamellipodium Assembly
Substantia Nigra Development
Establishment Of Cell Polarity
Actin Cytoskeleton Organization
Cell Differentiation
Macrophage Differentiation
Positive Regulation Of Cell Growth
Positive Regulation Of Cell Migration
Positive Regulation Of Pseudopodium Assembly
Negative Regulation Of Protein-containing Complex Assembly
Positive Regulation Of Cytokinesis
Regulation Of Actin Cytoskeleton Organization
Cell Junction Assembly
Adherens Junction Organization
Embryonic Heart Tube Development
Establishment Or Maintenance Of Apical/basal Cell Polarity
Dendritic Cell Migration
Neuropilin Signaling Pathway
Positive Regulation Of MAPK Cascade
Host-mediated Perturbation Of Viral Process
Establishment Of Epithelial Cell Apical/basal Polarity
Filopodium Assembly
Positive Regulation Of Pinocytosis
Neuron Fate Determination
Positive Regulation Of Cellular Component Organization
Regulation Of Filopodium Assembly
Positive Regulation Of Filopodium Assembly
Regulation Of Stress Fiber Assembly
Positive Regulation Of Stress Fiber Assembly
Nucleus Localization
Establishment Of Localization In Cell
Establishment Of Golgi Localization
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Regulation Of Attachment Of Spindle Microtubules To Kinetochore
Heart Contraction
Wnt Signaling Pathway, Planar Cell Polarity Pathway
Positive Regulation Of Epithelial Cell Proliferation Involved In Lung Morphogenesis
Dendritic Spine Morphogenesis
Cellular Response To Type II Interferon
Organelle Transport Along Microtubule
Endothelin Receptor Signaling Pathway Involved In Heart Process
Regulation Of Postsynapse Organization
Positive Regulation Of Substrate Adhesion-dependent Cell Spreading
Negative Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of Endothelial Cell Proliferation
Positive Regulation Of Mesenchymal Cell Proliferation
Positive Regulation Of Defense Response To Virus By Host
Negative Regulation Of Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis
Regulation Of DNA-templated Transcription
Regulation Of Transcription By RNA Polymerase II
Defense Response
Signal Transduction
Cell Surface Receptor Signaling Pathway Via JAK-STAT
Response To Nutrient
Blood Circulation
Positive Regulation Of Cell Population Proliferation
Response To Xenobiotic Stimulus
Response To Mechanical Stimulus
Negative Regulation Of Angiogenesis
Positive Regulation Of Interferon-alpha Production
Cellular Response To Insulin Stimulus
Tumor Necrosis Factor-mediated Signaling Pathway
Response To Cytokine
Response To Type II Interferon
Response To Interferon-beta
Cellular Response To Interferon-beta
Interleukin-7-mediated Signaling Pathway
Interleukin-9-mediated Signaling Pathway
Regulation Of Cell Population Proliferation
Response To Hydrogen Peroxide
Regulation Of Apoptotic Process
Negative Regulation Of Canonical NF-kappaB Signal Transduction
Response To Peptide Hormone
Endothelial Cell Migration
Positive Regulation Of Nitric Oxide Biosynthetic Process
Positive Regulation Of Erythrocyte Differentiation
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Receptor Signaling Pathway Via JAK-STAT
Negative Regulation By Virus Of Viral Protein Levels In Host Cell
Positive Regulation Of Smooth Muscle Cell Proliferation
Negative Regulation Of Developmental Process
Response To CAMP
Defense Response To Virus
Type II Interferon-mediated Signaling Pathway
Type I Interferon-mediated Signaling Pathway
Renal Tubule Development
Interleukin-27-mediated Signaling Pathway
Cellular Response To Cytokine Stimulus
Cellular Response To Type II Interferon
Metanephric Mesenchymal Cell Proliferation Involved In Metanephros Development
Metanephric Mesenchymal Cell Differentiation
Negative Regulation Of Metanephric Nephron Tubule Epithelial Cell Differentiation
Cell Surface Receptor Signaling Pathway Via STAT
Pathways
GPVI-mediated activation cascade
EGFR downregulation
Regulation of actin dynamics for phagocytic cup formation
Regulation of actin dynamics for phagocytic cup formation
CD28 dependent Vav1 pathway
EPHB-mediated forward signaling
EPHB-mediated forward signaling
DCC mediated attractive signaling
Inactivation of CDC42 and RAC1
VEGFA-VEGFR2 Pathway
Myogenesis
Myogenesis
RHO GTPases activate KTN1
RHO GTPases activate IQGAPs
RHO GTPases activate PAKs
RHO GTPases Activate WASPs and WAVEs
RHO GTPases Activate WASPs and WAVEs
RHO GTPases Activate Formins
RHO GTPases Activate Formins
MAPK6/MAPK4 signaling
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
G beta:gamma signalling through CDC42
CDC42 GTPase cycle
RAC1 GTPase cycle
RAC2 GTPase cycle
RHOQ GTPase cycle
RHOG GTPase cycle
RHOJ GTPase cycle
RHOU GTPase cycle
RAC3 GTPase cycle
RHOV GTPase cycle
FCGR3A-mediated phagocytosis
FCGR3A-mediated phagocytosis
Factors involved in megakaryocyte development and platelet production
Interleukin-6 signaling
ISG15 antiviral mechanism
Signaling by SCF-KIT
Signaling by cytosolic FGFR1 fusion mutants
Downstream signal transduction
Interleukin-4 and Interleukin-13 signaling
Interleukin-20 family signaling
Regulation of RUNX2 expression and activity
Interleukin-35 Signalling
Interleukin-9 signaling
NOTCH3 Intracellular Domain Regulates Transcription
NOTCH3 Intracellular Domain Regulates Transcription
Interleukin-27 signaling
Interleukin-21 signaling
Interferon alpha/beta signaling
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants
Signaling by PDGFRA extracellular domain mutants
Signaling by CSF3 (G-CSF)
Signaling by CSF1 (M-CSF) in myeloid cells
Inactivation of CSF3 (G-CSF) signaling
SARS-CoV-2 activates/modulates innate and adaptive immune responses
Signaling by ALK fusions and activated point mutants
Growth hormone receptor signaling
PKR-mediated signaling
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells
Regulation of PD-L1(CD274) transcription
Drugs
Aminophosphonic acid-guanylate ester
Guanosine-5'-Diphosphate
Diseases
Chronic Mucocutaneous Candidiasis (CMC); Familial candidiasis (CANDF)
IFN-gamma/IL-12 axis, including the following five diseases: IL-12 p40 subunit deficiency; IL-12 receptor (IL-12R) beta1 chain deficiency; IFN-gamma receptor (IFN gamma R) alpha chain deficiency; IFN-gamma receptor (IFN gamma R) beta chain deficiency; STAT-1 deficiency
GWAS
Colorectal cancer (
25990418
)
Daytime sleep phenotypes (
27126917
)
Extremely high intelligence (
29520040
)
Gestational age at birth (maternal effect) (
28877031
)
Gynecologic disease (
31488892
)
Gynecologic disease (multivariate analysis) (
31488892
)
Hip circumference adjusted for BMI (
34021172
)
Immune response to smallpox vaccine (IL-6) (
22610502
)
Liver enzyme levels (alkaline phosphatase) (
33972514
)
Metabolite levels (
23823483
)
Uterine fibroids (
30194396
31249589
31488892
31649266
)
Uterine fibroids (MTAG) (
31488892
)
Birth weight (
31043758
)
Height (
31562340
)
Inflammatory bowel disease (
23128233
)
JT interval (sulfonylurea treatment interaction) (
27958378
)
Limited cutaneous systemic scleroderma (
29293537
)
Lung cancer (SNP x SNP interaction) (
24325914
)
Metabolite levels (
23823483
)
Neutrophil percentage of granulocytes (
27863252
)
Primary biliary cholangitis (
26394269
28425483
)
Primary biliary cirrhosis (
22961000
)
Systemic lupus erythematosus (
26316170
)
Systemic sclerosis (
29293537
)
Interacting Genes
383 interacting genes:
A2M
AARS1
ACADM
ACO1
ACO2
ACOT7
ACTR3
ADRM1
AGAP1
AGAP2
AHSG
AKR1B1
ALDH18A1
ANAPC13
ANXA11
ANXA2
AP3D1
APEX1
APOH
ARAP1
ARAP2
ARG1
ARHGAP1
ARHGAP10
ARHGAP11B
ARHGAP17
ARHGAP20
ARHGAP22
ARHGAP26
ARHGAP27
ARHGAP31
ARHGAP32
ARHGAP35
ARHGAP39
ARHGAP40
ARHGAP44
ARHGDIA
ARHGDIB
ARHGDIG
ARHGEF10
ARHGEF11
ARHGEF15
ARHGEF25
ARHGEF26
ARHGEF4
ARHGEF6
ARHGEF7
ARHGEF9
ARRB1
ARRB2
ATP5F1C
ATP5IF1
ATP5MF
ATP5PD
ATP6V1A
BAIAP2
BCAP31
BCCIP
BCL2L13
BCR
BIRC2
BLMH
BNIP2
BRD10
BTF3
BZW2
CALML5
CAPNS1
CAPZB
CARHSP1
CASP14
CASP3
CASP7
CBLL1
CBX3
CCN1
CDC42BPA
CDC42BPB
CDC42BPG
CDC42EP1
CDC42EP2
CDC42EP3
CDC42EP4
CDC42EP5
CDC42SE1
CDC5L
CDH1
CDKN2A
CEBPA
CFHR4
CGN
CMPK1
CNBP
CNOT1
COL1A1
COMT
COPA
COPE
COPG1
CPN1
CRIP2
CSE1L
CSN2
CSPG4
CTNNA1
DEF6
DEK
DHFR
DIAPH1
DIAPH2
DIAPH3
DNMBP
DOCK7
DOCK8
DOCK9
DPYSL2
DSG1
DSP
ECHS1
EDC4
EDF1
EEF1E1
EEF1G
EHD2
EHD4
EIF2AK2
EIF3D
EIF3F
EIF5
EIF5B
EPHA2
EPRS1
ERCC3
ERG28
ERICH6
ERRFI1
ETFA
FAM13B
FGD1
FGD2
FGD3
FGD4
FKBP10
FKBP1A
FKBP3
FLNA
FLNC
FMN2
FMNL2
FNBP1
FNBP1L
FNDC3B
FTH1
G6PD
GALNT2
GART
GDI1
GIT2
GLS
GMIP
GNB1
GRB2
GRWD1
GSR
GSTM5
H1-10
H1-5
H2BC13
HADH
HADHB
HDAC7
HDLBP
HERC2
HLA-G
HMGN1
HNRNPAB
HNRNPUL2
HSD17B10
HYOU1
IARS1
IGF2BP1
IPO5
IQGAP1
IQGAP2
ITSN1
JPT2
KARS1
KAT5
KHDRBS1
KPNA2
KTN1
KYNU
LARS1
LCK
LGALS1
LGALS7
LONP1
LRIF1
LRP2
LYZ
MAP2K3
MAP3K10
MAP3K11
MAP3K19
MAP3K4
MAP4
MAPRE1
MARCKSL1
MARK4
MASTL
MATR3
MCF2L
MCM3AP
MCM6
MCM7
MDH1
MDK
METAP2
MRM1
MRPL49
MSH2
MT-CO1
MTDH
MUC12
MYO1C
MYO6
MYO9A
NAA15
NASP
NCAPD2
NCF2
NEK6
NIBAN2
NOP2
NPLOC4
NQO1
NUDT21
NUP155
OCRL
OLA1
OPHN1
P3H1
PABPC4
PAK1
PAK2
PAK3
PAK4
PAK5
PAK6
PALLD
PARD3
PARD6A
PARD6B
PARD6G
PAXX
PCM1
PCNP
PDCD5
PDE6C
PDE6D
PGD
PGGT1B
PHAX
PHB2
PHPT1
PICALM
PIK3R1
PLD1
PLEKHG1
PLEKHG2
PLEKHG3
PLEKHG4
PLEKHG4B
PMS1
PPP2R1A
PRDX3
PREX2
PRKCA
PRKCG
PRKCI
PRKCZ
PSAT1
PSIP1
PSMB1
PSMC5
PSMC6
PSMD11
PSMD12
PSMD3
PSME3
PXDN
RAC2
RAP1GDS1
RARS1
RASGRF2
RBM8A
RHOJ
RIOK3
RO60
RPL22
RPL23
RPS15
RPS21
RPS6KB1
RRM1
S100A9
SDHA
SEPTIN2
SERPINB1
SERPINB2
SERPINB3
SF1
SF3A2
SH3BGRL3
SH3D19
SLC16A3
SMC2
SNCA
SNRNP70
SPATA13
SRGAP1
SRM
SRP72
SRSF1
SSB
SSX2IP
ST13
STARD8
STAT1
STAU1
STMN2
SYNE1
TBC1D3F
TBCA
TCEAL3
TIAM1
TMED10
TMED9
TMOD3
TMX1
TNFRSF10B
TNK2
TOR1AIP1
TP53
TPD52L2
TPM1
TRAF2
TRIM28
TRIM45
TRIM60
TRIO
TRIP10
TRRAP
TSFM
TTC12
TUBB3
TXNL1
TYMS
U2AF2
UBC
UBE2L3
UBR1
UGDH
UNC119
USP6
VARS1
VASP
VAV1
VRK2
WAS
WASF1
WASF2
WASL
WIPF1
XIAP
XPO1
YARS1
YWHAH
ZNF175
ZNF234
ZNF415
ZNF420
ZNF622
112 interacting genes:
ACTN4
ADRA1B
AIRN
AKT1
ATF3
BMX
BRCA1
CAMK2A
CAMK2D
CAMK2G
CASP3
CASP7
CCR1
CCR5
CDC42
CEBPA
CREBBP
CSE1L
CSF2RB
CXCR4
DCTN1
DDB1
DDX6
DOT1L
DUSP2
DUSP3
E2F1
EGFR
EIF1AD
EIF2AK2
ELP2
EP300
FADD
FANCC
FGFR3
FGFR4
FLT1
FOS
FTH1
FYN
GFAP
GTF2I
HADH
HLA-B
HSF1
HSP90AB1
HSPA8
IFNAR2
IFNGR1
IL27RA
IL2RB
IL2RG
IRF1
IRF2
IRF9
JAK1
JAK2
JUN
KDR
KIT
KPNA1
KPNA6
LCK
LMO2
LZTR1
MAPK14
MAVS
MCM3
MCM5
MDK
MT-ND4L
NMI
NOMO1
NOMO2
OTUD4
PDGFRA
PDGFRB
PIAS1
PIAS2
PIK3CA
PKNOX1
POR
PRKCD
PRMT1
PRMT3
PTK2
PTPN11
PTPN2
RAC1
RACK1
RELA
RPS6KA5
RXRA
SHANK1
SPTAN1
SPTB
SPTBN1
SRC
STAT2
STAT3
STAT5A
STAT5B
SUMO4
SYK
TNFRSF1A
TNFRSF1B
TRADD
TYK2
UBE2I
VDR
XPO1
ZNF467
Entrez ID
998
6772
HPRD ID
00309
02777
Ensembl ID
ENSG00000070831
ENSG00000115415
Uniprot IDs
P60953
A0A669KB68
A0A8V8TN81
P42224
PDB IDs
1A4R
1AJE
1AM4
1AN0
1CEE
1CF4
1DOA
1E0A
1EES
1GRN
1GZS
1KI1
1KZ7
1KZG
1NF3
2ASE
2DFK
2KB0
2NGR
2ODB
2QRZ
2WM9
2WMN
2WMO
3GCG
3QBV
3VHL
4DID
4ITR
4JS0
4YC7
4YDH
5CJP
5FI1
5HZK
5UPK
5UPL
6AJ4
6AJL
6SIU
6SUP
6TKY
6TKZ
7S0Y
8I5F
1BF5
1YVL
2KA6
3WWT
7NUF
8D3F
Enriched GO Terms of Interacting Partners
?
Cytosol
Cytoplasm
Regulation Of Small GTPase Mediated Signal Transduction
GTPase Activator Activity
Regulation Of Intracellular Signal Transduction
Small GTPase Binding
Guanyl-nucleotide Exchange Factor Activity
Actin Filament-based Process
Small GTPase-mediated Signal Transduction
Actin Cytoskeleton Organization
Intracellular Signaling Cassette
Lamellipodium
Intracellular Signal Transduction
Regulation Of Signal Transduction
Cytoskeleton Organization
RNA Binding
Regulation Of Signaling
Regulation Of Cell Communication
Rho Protein Signal Transduction
Extracellular Exosome
Organelle Organization
Cadherin Binding
Cell-cell Junction
Regulation Of Actin Cytoskeleton Organization
Cell Projection Organization
Cell Cortex
PAR Polarity Complex
Biological_process
Regulation Of Actin Filament-based Process
Ruffle
Actin Filament Organization
Regulation Of Cytoskeleton Organization
Regulation Of Cell Shape
Regulation Of Cellular Component Organization
Protein Serine Kinase Activity
Supramolecular Fiber Organization
Anchoring Junction
Regulation Of Protein Metabolic Process
Actin Cytoskeleton
Cellular Component Assembly
Regulation Of Programmed Cell Death
Regulation Of Actin Filament Organization
Actin Binding
Cytoskeleton
Positive Regulation Of Cellular Component Organization
Regulation Of Supramolecular Fiber Organization
Regulation Of Cell Morphogenesis
Actin Filament
Protein Serine/threonine Kinase Activity
Regulation Of Rho Protein Signal Transduction
Cell Surface Receptor Signaling Pathway
Cytokine-mediated Signaling Pathway
Regulation Of Cell Communication
Regulation Of Signal Transduction
Regulation Of Signaling
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Protein Tyrosine Kinase Activity
Positive Regulation Of Signal Transduction
Regulation Of Macromolecule Metabolic Process
Cell Surface Receptor Signaling Pathway Via JAK-STAT
Regulation Of Metabolic Process
Signal Transduction
Regulation Of Multicellular Organismal Process
Cell Surface Receptor Signaling Pathway Via STAT
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Regulation Of Primary Metabolic Process
Enzyme-linked Receptor Protein Signaling Pathway
Positive Regulation Of Metabolic Process
Regulation Of Intracellular Signal Transduction
Intracellular Signal Transduction
Positive Regulation Of Intracellular Signal Transduction
Regulation Of Macromolecule Biosynthetic Process
Regulation Of Gene Expression
Regulation Of Developmental Process
Positive Regulation Of Macromolecule Metabolic Process
Response To Stress
Positive Regulation Of Multicellular Organismal Process
Regulation Of Programmed Cell Death
Positive Regulation Of Developmental Process
Positive Regulation Of Biosynthetic Process
Regulation Of Apoptotic Process
Immune System Process
Protein Kinase Activity
Regulation Of Cell Population Proliferation
Regulation Of Nucleobase-containing Compound Metabolic Process
Non-membrane Spanning Protein Tyrosine Kinase Activity
Regulation Of Immune System Process
Phosphorylation
Protein Phosphorylation
Regulation Of Defense Response
Regulation Of Cell Differentiation
Regulation Of Multicellular Organismal Development
Peptidyl-tyrosine Phosphorylation
Positive Regulation Of Cell Migration
Kinase Activity
Response To Lipid
Defense Response
Response To Peptide
Positive Regulation Of Cell Differentiation
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