RHOQ and PRKCI

Number of citations of the paper that reports this interaction (PMID 10934474)
205

Data Source:
HPRD (two hybrid)

		RHOQ	PRKCI
Gene Name		ras homolog family member Q	protein kinase C, iota
Image
Gene Ontology Annotations	Cellular Component	Cytosol Actin Filament Plasma Membrane Membrane Raft Extracellular Vesicular Exosome	Golgi Membrane Nucleus Cytoplasm Endosome Cytosol Plasma Membrane Tight Junction Microtubule Cytoskeleton Apical Plasma Membrane Cell Leading Edge Schmidt-Lanterman Incisure Protein Complex Intercellular Bridge Extracellular Vesicular Exosome
	Molecular Function	GTPase Activity Profilin Binding GTP Binding GBD Domain Binding	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Kinase C Activity Protein Binding ATP Binding Phospholipid Binding Protein Domain Specific Binding Metal Ion Binding
	Biological Process	Small GTPase Mediated Signal Transduction Insulin Receptor Signaling Pathway Regulation Of Cell Shape Cortical Actin Cytoskeleton Organization Cellular Response To Insulin Stimulus Regulation Of Actin Cytoskeleton Organization Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Glucose Import Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of Filopodium Assembly Negative Regulation Of Establishment Of Protein Localization To Plasma Membrane	Protein Phosphorylation Protein Targeting To Membrane Cytoskeleton Organization Actin Filament Organization Positive Regulation Of Neuron Projection Development Vesicle-mediated Transport Cell Migration Cellular Response To Insulin Stimulus Cell Junction Assembly Negative Regulation Of Glial Cell Apoptotic Process Establishment Of Apical/basal Cell Polarity Intracellular Signal Transduction Eye Photoreceptor Cell Development Negative Regulation Of Apoptotic Process Negative Regulation Of Neuron Apoptotic Process Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Cell-cell Junction Organization Positive Regulation Of Glucose Import Secretion Neurotrophin TRK Receptor Signaling Pathway Golgi Vesicle Budding Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Glial Cell Proliferation Membrane Organization Response To Interleukin-1 Tight Junction Assembly Positive Regulation Of Establishment Of Protein Localization To Plasma Membrane Positive Regulation Of Endothelial Cell Apoptotic Process
Pathways		Rho GTPase cycle Signaling by Rho GTPases Translocation of GLUT4 to the plasma membrane	Cell junction organization Cell-cell junction organization Signalling by NGF p75NTR recruits signalling complexes Tight junction interactions p75NTR signals via NF-kB p75 NTR receptor-mediated signalling
Drugs
Diseases
GWAS
Protein-Protein Interactions		18 interactors: CDC42BPG CDC42EP1 CDC42EP2 CDC42EP3 CDC42EP4 COPB1 COPG1 DOCK8 EXOC7 GOPC PARD6A PARD6B PFN1 PRKCI RAPGEF1 TRIP10 TRIP6 WASL	41 interactors: ADAP1 ANXA1 APP BAD CASP8 CDC42 CDK7 CHUK FABP4 FRS2 FRS3 GAPDH HRAS IKBKG IL1RAP IRAK1 MAP2K1 MAP2K5 MARK4 MBP NFKBIA PARD3 PARD6A PARD6B PARD6G PDPK1 PNMA1 RAB2A RAB4A RAC1 RHOQ SMG1 SQSTM1 SRC TSC22D1 TTR UBC USP20 VHL YWHAH YWHAZ
Entrez ID		23433	5584
HPRD ID		05791	02105
Ensembl ID			ENSG00000163558
Uniprot IDs		P17081	P41743
PDB IDs		2ATX	1VD2 1WMH 1ZRZ 3A8W 3A8X 3ZH8
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Cell Projection Organization Positive Regulation Of Pseudopodium Assembly Regulation Of Cell Projection Assembly Regulation Of Cell Projection Organization Positive Regulation Of Cytoskeleton Organization Positive Regulation Of Actin Filament Polymerization Positive Regulation Of Protein Polymerization Positive Regulation Of Cellular Component Biogenesis Golgi Vesicle Budding Positive Regulation Of Protein Complex Assembly Regulation Of Actin Cytoskeleton Organization Regulation Of Actin Filament Polymerization Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Membrane Budding Positive Regulation Of Organelle Organization Regulation Of Actin Filament-based Process Regulation Of Cytoskeleton Organization Regulation Of Catalytic Activity Intracellular Signal Transduction Regulation Of Cellular Component Size Actin Cytoskeleton Organization Regulation Of Cellular Component Organization Regulation Of Protein Complex Assembly Small GTPase Mediated Signal Transduction Localization Within Membrane Vesicle-mediated Transport Actin Filament-based Process Positive Regulation Of Hydrolase Activity Regulation Of Cell Shape Tight Junction Assembly Rho Protein Signal Transduction Positive Regulation Of GTPase Activity Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of Ras GTPase Activity Cell Junction Assembly Regulation Of GTPase Activity Vesicle Organization Cell-cell Junction Organization Ras Protein Signal Transduction Apical Junction Assembly Organelle Organization Positive Regulation Of Rho GTPase Activity COPI-coated Vesicle Budding COPI Coating Of Golgi Vesicle Regulation Of Organelle Organization Regulation Of Ras GTPase Activity Golgi Vesicle Transport Regulation Of Rho GTPase Activity Positive Regulation Of Catalytic Activity	Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Defense Response Cellular Response To Growth Factor Stimulus Response To Growth Factor Enzyme Linked Receptor Protein Signaling Pathway Immune Response Regulation Of Cell Death Innate Immune Response Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Immune Response-regulating Signaling Pathway Fc Receptor Signaling Pathway Cellular Response To Stimulus Regulation Of Apoptotic Process Immune System Process Response To Stress Response To Stimulus Intracellular Signal Transduction Signaling Cellular Response To Organic Substance Signal Transduction Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Cell Communication Regulation Of Cellular Protein Metabolic Process Immune Response-regulating Cell Surface Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Intracellular Receptor Signaling Pathway Regulation Of Kinase Activity Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Fc-epsilon Receptor Signaling Pathway Regulation Of Protein Metabolic Process Regulation Of Protein Phosphorylation Fibroblast Growth Factor Receptor Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Response To Organic Substance Positive Regulation Of Programmed Cell Death Regulation Of Phosphorylation Negative Regulation Of Programmed Cell Death Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Cellular Metabolic Process TRIF-dependent Toll-like Receptor Signaling Pathway Positive Regulation Of Cell Death Positive Regulation Of Kinase Activity MyD88-independent Toll-like Receptor Signaling Pathway Cellular Response To Fibroblast Growth Factor Stimulus Toll-like Receptor 3 Signaling Pathway Apoptotic Process Response To Fibroblast Growth Factor Negative Regulation Of Cell Death
Tagcloud ?			abcc4 aberrations amplification amplifications amplified array azd6244 comparative comprehensive ctsb erbb2 fgfr2 focal gastric genome knocked kras mek1 met opportunities pak1 specimens stard13 summary targeted therapeutics whole worldwide worse
Tagcloud (Difference) ?			abcc4 aberrations amplification amplifications amplified array azd6244 comparative comprehensive ctsb erbb2 fgfr2 focal gastric genome knocked kras mek1 met opportunities pak1 specimens stard13 summary targeted therapeutics whole worldwide worse
Tagcloud (Intersection) ?