RHOQ and CDC42EP1

Number of citations of the paper that reports this interaction (PMID 10490598)
24

Data Source:
HPRD (two hybrid, in vitro)

		RHOQ	CDC42EP1
Gene Name		ras homolog family member Q	CDC42 effector protein (Rho GTPase binding) 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Actin Filament Plasma Membrane Membrane Raft Extracellular Vesicular Exosome	Cytoplasm Golgi Apparatus Plasma Membrane Focal Adhesion Actin Cytoskeleton
	Molecular Function	GTPase Activity Profilin Binding GTP Binding GBD Domain Binding	Rho GTPase Activator Activity Protein Binding GTP-Rho Binding
	Biological Process	Small GTPase Mediated Signal Transduction Insulin Receptor Signaling Pathway Regulation Of Cell Shape Cortical Actin Cytoskeleton Organization Cellular Response To Insulin Stimulus Regulation Of Actin Cytoskeleton Organization Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Glucose Import Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of Filopodium Assembly Negative Regulation Of Establishment Of Protein Localization To Plasma Membrane	Rho Protein Signal Transduction Regulation Of Cell Shape Positive Regulation Of Actin Filament Polymerization Positive Regulation Of Pseudopodium Assembly Positive Regulation Of Rho GTPase Activity
Pathways		Rho GTPase cycle Signaling by Rho GTPases Translocation of GLUT4 to the plasma membrane
Drugs
Diseases
GWAS
Protein-Protein Interactions		18 interactors: CDC42BPG CDC42EP1 CDC42EP2 CDC42EP3 CDC42EP4 COPB1 COPG1 DOCK8 EXOC7 GOPC PARD6A PARD6B PFN1 PRKCI RAPGEF1 TRIP10 TRIP6 WASL	10 interactors: CDC42 DEF6 FHL3 KRTAP4-12 MAPKAP1 MDFI PLSCR1 RBPMS RHOJ RHOQ
Entrez ID		23433	11135
HPRD ID		05791	07303
Ensembl ID			ENSG00000128283
Uniprot IDs		P17081	Q00587
PDB IDs		2ATX
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Cell Projection Organization Positive Regulation Of Pseudopodium Assembly Regulation Of Cell Projection Assembly Regulation Of Cell Projection Organization Positive Regulation Of Cytoskeleton Organization Positive Regulation Of Actin Filament Polymerization Positive Regulation Of Protein Polymerization Positive Regulation Of Cellular Component Biogenesis Golgi Vesicle Budding Positive Regulation Of Protein Complex Assembly Regulation Of Actin Cytoskeleton Organization Regulation Of Actin Filament Polymerization Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Membrane Budding Positive Regulation Of Organelle Organization Regulation Of Actin Filament-based Process Regulation Of Cytoskeleton Organization Regulation Of Catalytic Activity Intracellular Signal Transduction Regulation Of Cellular Component Size Actin Cytoskeleton Organization Regulation Of Cellular Component Organization Regulation Of Protein Complex Assembly Small GTPase Mediated Signal Transduction Localization Within Membrane Vesicle-mediated Transport Actin Filament-based Process Positive Regulation Of Hydrolase Activity Regulation Of Cell Shape Tight Junction Assembly Rho Protein Signal Transduction Positive Regulation Of GTPase Activity Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of Ras GTPase Activity Cell Junction Assembly Regulation Of GTPase Activity Vesicle Organization Cell-cell Junction Organization Ras Protein Signal Transduction Apical Junction Assembly Organelle Organization Positive Regulation Of Rho GTPase Activity COPI-coated Vesicle Budding COPI Coating Of Golgi Vesicle Regulation Of Organelle Organization Regulation Of Ras GTPase Activity Golgi Vesicle Transport Regulation Of Rho GTPase Activity Positive Regulation Of Catalytic Activity	Regulation Of Signal Transduction Regulation Of Signaling Actin Cytoskeleton Organization Actin Filament-based Process Regulation Of Establishment Of Protein Localization Substantia Nigra Development Regulation Of Intracellular Protein Transport Regulation Of Small GTPase Mediated Signal Transduction Regulation Of Protein Localization Regulation Of Filopodium Assembly Neural Nucleus Development Regulation Of Intracellular Signal Transduction Intracellular Signal Transduction T Cell Costimulation Regulation Of Cellular Localization Midbrain Development Regulation Of Intracellular Transport Cytoskeleton Organization Regulation Of Cell Activation Regulation Of Cell Morphogenesis Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Hair Follicle Cell Proliferation Regulation Of Cell Projection Assembly Positive Regulation Of JNK Cascade Defense Response Positive Regulation Of Stress-activated MAPK Cascade Positive Regulation Of Stress-activated Protein Kinase Signaling Cascade Actin Filament Branching Positive Regulation Of DNA Topoisomerase (ATP-hydrolyzing) Activity Submandibular Salivary Gland Formation Positive Regulation Of Cellular Metabolic Process Small GTPase Mediated Signal Transduction Regulation Of Protein Transport Regulation Of Hair Follicle Cell Proliferation Positive Regulation Of Synapse Structural Plasticity Positive Regulation Of Intracellular Protein Transport Regulation Of Cell Shape Regulation Of JNK Cascade Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Regulation Of Protein Import Into Nucleus Positive Regulation Of Protein Phosphorylation Regulation Of Stress-activated MAPK Cascade Positive Regulation Of Transport Establishment Of Golgi Localization Phosphatidylserine Biosynthetic Process Regulation Of Protein Localization To Nucleus Positive Regulation Of Metalloenzyme Activity Organ Development
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