COIL and ACTN1

Number of citations of the paper that reports this interaction (PubMedID 16713569)
0

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		COIL	ACTN1
Description		coilin	actinin alpha 1
Image		No pdb structure
GO Annotations	Cellular Component	Fibrillar Center Nucleus Nucleoplasm Nucleolus Cajal Body Membrane Nuclear Body	Stress Fiber Ruffle Extracellular Region Extracellular Space Cytoplasm Cytosol Cytoskeleton Actin Filament Plasma Membrane Brush Border Cell-cell Junction Fascia Adherens Focal Adhesion Actin Cytoskeleton Membrane Sarcomere Z Disc Cell Junction Cortical Actin Cytoskeleton Platelet Alpha Granule Lumen Pseudopodium Cell Projection Synapse Extracellular Exosome Anchoring Junction Glutamatergic Synapse
	Molecular Function	Protein Binding U1 SnRNA Binding U2 SnRNA Binding Identical Protein Binding	Transcription Coactivator Activity Double-stranded RNA Binding Actin Binding Integrin Binding Calcium Ion Binding Protein Binding Cytoskeletal Protein Binding Vinculin Binding Identical Protein Binding Protein Homodimerization Activity Transmembrane Transporter Binding Metal Ion Binding Actin Filament Binding Structural Constituent Of Postsynapse
	Biological Process	Spliceosomal SnRNP Assembly	Actin Filament Organization Actin Cytoskeleton Organization Platelet Activation Platelet Formation Platelet Morphogenesis Regulation Of Apoptotic Process Positive Regulation Of DNA-templated Transcription Focal Adhesion Assembly Anatomical Structure Formation Involved In Morphogenesis Actin Filament Bundle Assembly Actin Filament Network Formation Muscle Cell Development Platelet Aggregation Postsynapse Organization
Pathways			Platelet degranulation Syndecan interactions Nephrin family interactions Regulation of cytoskeletal remodeling and cell spreading by IPP complex components RHOD GTPase cycle RHOBTB2 GTPase cycle RHOF GTPase cycle
Drugs			Human calcitonin Copper
Diseases
GWAS		Height ( 18391951)	Asthma ( 31959851) Cognitive decline rate in late mild cognitive impairment ( 26252872) Feeling fed-up ( 29500382) Feeling hurt ( 29500382) Fibrinogen ( 23969696) Fibrinogen levels ( 28107422) High light scatter reticulocyte count ( 32888494) Lack of perseverance ( 30718321) Mean platelet volume ( 27863252 32888494) Medication use (drugs used in diabetes) ( 31015401) Mosquito bite size ( 28199695) Neurociticism ( 29500382) Periodontitis (Mean PAL) ( 24024966) Platelet count ( 29403010 26805783 32888494) Platelet distribution width ( 27863252 32888494) Plateletcrit ( 32888494) Prostate cancer ( 23535732) Rheumatoid arthritis (ACPA-positive) ( 23143596) Smoking behavior ( 19247474) Urinary albumin excretion ( 30220432)
Interacting Genes		84 interacting genes: ACTN1 ACTN2 ACTN4 ADAMTS12 APP ARMCX1 ATXN1 ATXN1L BYSL C1QBP C9orf72 CCDC136 CCDC159 CCDC57 CCNE1 CDC23 CDK2 CEP70 CEP76 CSNK2B CYB5R2 DHX16 DNAJA3 DRG1 DYNC2I2 ELOA2 FGF12 FHL5 FXR1 FXR2 GCC1 HSF2BP KALRN KAZN KDM1A KLC2 KLC4 KLHL42 KLHL8 KPNA3 LNX1 MAD1L1 MCRS1 MYO15B MYO5B NFU1 NIF3L1 NKAPD1 NOLC1 NTAQ1 NUDT18 OGT PDE4D PDLIM5 PIAS4 PICK1 PLEKHG4 PLOD3 POLR2L POLR3C PREPL PRMT1 PRMT8 PSMA1 PSME3 PTS SART3 SCYL1 SMN1 SNRPB SNRPF SNX6 SPANXN2 SRPK2 TAF9 TCAF1 TFCP2 TGS1 TSPYL2 XRCC5 XRCC6 ZBTB25 ZCCHC10 ZNF277	93 interacting genes: ACTN3 ADORA2A APC APPBP2 ATXN2 ATXN7 CACNA1A CAMK2A CBY2 CDK5 CDK5R1 CDK5R2 CEBPA CLIC5 COIL COL17A1 CSRP1 CSRP3 CTNNA1 DDIAS DSCAM DYNLT1 EIF2S1 EPM2AIP1 ERBIN FBP1 FILNC1 FXN FXR1 GADD45G GFI1B GIPC1 GIT2 GRIA4 GRIN2A GRM5 GTF2H1 HSPB1 ICAM5 ITGB1 KAT2B KCTD6 KPNA2 LINC01554 LNX1 LPP MAGEA11 MAP2 MAP3K1 MED14 MICALL2 MTDH MTNR1A MTNR1B MYOT MYOZ1 MYOZ2 MYOZ3 NEBL NKAPD1 NR1H3 NUMBL OAS1 PALLD PDHX PDLIM1 PDLIM5 PIAS4 PKD1 PKN1 PLD2 PSEN1 PSMA1 PTK2 PTPN1 PTPN6 PYGB RAVER1 RPS27 SIRPA SLC2A4 SORBS2 SRC SSX2IP SYNPO2L TES TSC1 TTN TXN USP2 VCL XRCC4 ZYX
Entrez ID		8161	87
HPRD ID		02605	00020
Ensembl ID		ENSG00000121058	ENSG00000072110
Uniprot IDs		P38432	A0A024R694 A0A7I2V4Y4 A0A804HL31 A0A804HLF4 H9KV75 P12814
PDB IDs			2EYI 2EYN 2N8Y 2N8Z
Enriched GO Terms of Interacting Partners?		Cytoplasm Cytosol Nucleoplasm Macromolecule Metabolic Process Nucleic Acid Metabolic Process Spliceosomal SnRNP Assembly Nucleus Cellular Component Assembly Nucleobase-containing Compound Metabolic Process Protein-RNA Complex Assembly 7-methylguanosine Cap Hypermethylation Cajal Body Protein Binding Methylosome RNA Metabolic Process Transmembrane Transporter Binding Cytoskeleton Z Disc Pseudopodium Negative Regulation Of DNA Metabolic Process Cyclin E1-CDK2 Complex DNA End Binding Ku70:Ku80 Complex SMN-Sm Protein Complex Small Nuclear Ribonucleoprotein Complex Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Spliceosomal Complex Assembly Regulation Of Protein Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Postsynapse Telomere Maintenance POZ Domain Binding Nucleolus Main Axon DNA-dependent Protein Kinase Complex Protein-arginine Omega-N Monomethyltransferase Activity Peptidyl-arginine Methylation Regulation Of RNA Metabolic Process Macromolecule Methylation DNA-templated Transcription Identical Protein Binding Regulation Of Long-term Neuronal Synaptic Plasticity Protein Modification Process Platelet Alpha Granule Lumen Protein-containing Complex Assembly Negative Regulation Of Double-strand Break Repair Via Homologous Recombination Telomeric DNA Binding Cellular Response To Gamma Radiation RNA Splicing Telomere Organization	Z Disc Cell Adhesion Cytoplasm Actin Binding Actin Cytoskeleton Actinin Binding Actin Cytoskeleton Organization Telethonin Binding Anchoring Junction Actomyosin Structure Organization Actin Filament-based Process Cell-cell Adhesion Cytoskeleton Organization Sarcomere Organization Structural Constituent Of Muscle Focal Adhesion Regulation Of Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Stress Fiber Cell Junction Organization Cell Projection Protein Kinase 5 Complex Cell-substrate Adhesion Regulation Of Protein Localization Regulation Of Programmed Cell Death Muscle Alpha-actinin Binding Negative Regulation Of Signal Transduction Cell Surface Receptor Signaling Pathway Dendritic Spine FATZ Binding Regulation Of Apoptotic Process Cell-matrix Adhesion Regulation Of Multicellular Organismal Process Regulation Of Synaptic Transmission, Glutamatergic Negative Regulation Of Cell Communication Protein Binding Negative Regulation Of Signaling Neuronal Cell Body Synaptic Transmission, Glutamatergic Regulation Of Intracellular Signal Transduction Detection Of Muscle Stretch Organelle Organization Protein Kinase Binding Positive Regulation Of Apoptotic Process Contractile Actin Filament Bundle Assembly Stress Fiber Assembly Regulation Of Generation Of Precursor Metabolites And Energy Cadherin Binding Cellular Response To Amyloid-beta
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