TACC3 and KAT2A

Number of citations of the paper that reports this interaction (PMID 14767476)
12

Data Source:
BioGRID (pull down)
HPRD (in vitro)

		TACC3	KAT2A
Gene Name		transforming, acidic coiled-coil containing protein 3	K(lysine) acetyltransferase 2A
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Centrosome	Extracellular Space Nucleoplasm Ada2/Gcn5/Ada3 Transcription Activator Complex STAGA Complex Transcription Factor TFTC Complex Mitotic Spindle
	Molecular Function	Protein Binding Protein Domain Specific Binding	Chromatin Binding Transcription Coactivator Activity Histone Acetyltransferase Activity Protein Binding H3 Histone Acetyltransferase Activity Histone Deacetylase Binding Histone Acetyltransferase Activity (H4-K12 Specific)
	Biological Process	Microtubule Cytoskeleton Organization Response To Hypoxia Cell Proliferation Cerebral Cortex Development Neurogenesis Interkinetic Nuclear Migration Hemopoiesis Astral Microtubule Organization Regulation Of Microtubule-based Process Cytoplasmic Sequestering Of Transcription Factor Regulation Of Cell Cycle	In Utero Embryonic Development Somitogenesis Neural Tube Closure Chromatin Organization Chromatin Remodeling Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Cell Proliferation Viral Process Histone Deubiquitination Telencephalon Development Metencephalon Development Midbrain Development Regulation Of Protein Stability Multicellular Organism Growth Positive Regulation Of Gluconeogenesis By Positive Regulation Of Transcription From RNA Polymerase II Promoter Histone H3 Acetylation Histone H4-K12 Acetylation Histone H3-K14 Acetylation
Pathways			Signaling by NOTCH1 HD Domain Mutants in Cancer RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer RNA Polymerase I Transcription Initiation RNA Polymerase I Promoter Clearance HATs acetylate histones Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Generic Transcription Pathway Pre-NOTCH Transcription and Translation Signaling by NOTCH1 Pre-NOTCH Expression and Processing Signaling by NOTCH1 in Cancer Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants FBXW7 Mutants and NOTCH1 in Cancer Chromatin organization RNA Polymerase I Transcription Signaling by NOTCH Notch-HLH transcription pathway NOTCH1 Intracellular Domain Regulates Transcription Chromatin modifying enzymes Signaling by NOTCH1 PEST Domain Mutants in Cancer Constitutive Signaling by NOTCH1 PEST Domain Mutants
Drugs
Diseases
GWAS		Bladder cancer ( 20972438) Urinary bladder cancer ( 20348956)
Protein-Protein Interactions		13 interactors: AKAP9 ARNT2 ASPSCR1 AURKA CDH1 CIB3 KAT2A KIZ NDEL1 SNX20 TBC1D22B TTF2 VPS37C	45 interactors: ATXN7 BATF2 BRCA1 CDK2 CEBPB COMMD1 CREBBP CRX CTNNB1 CUL2 DTL EID1 EP300 GATA2 HIST1H1B HIST1H3A HIST1H4A HIST2H2AC HIST2H2BE HIST2H3C HIST2H4A HIST3H3 HIST4H4 HSD11B2 IRF1 IRF2 IRF7 MYB MYC NOTCH1 PBX1 PPARG PRKDC PYGO2 RBPJ RELA SIRT2 SUMO1 TACC1 TACC2 TACC3 TADA2A TCF3 TRRAP XRCC6
Entrez ID		10460	2648
HPRD ID		05601	03807
Ensembl ID		ENSG00000013810	ENSG00000108773
Uniprot IDs		Q9Y6A5	Q92830
PDB IDs			1F68 1Z4R 3D7C
Enriched GO Terms of Interacting Partners?		Mitotic Centrosome Separation Centrosome Separation Positive Regulation Of Metabolic Process Centrosome Localization In Utero Embryonic Development Cell Cycle Process Embryo Development Mitotic Cell Cycle Process Centrosome Cycle Cell Cycle Neuron Projection Extension Mitotic Cell Cycle Brain Development Mitotic Nuclear Division Chordate Embryonic Development Embryo Development Ending In Birth Or Egg Hatching Head Development Negative Regulation Of Spindle Checkpoint Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Membrane Organization Developmental Cell Growth Positive Regulation Of Cellular Metabolic Process Centrosome Organization Spindle Assembly Involved In Female Meiosis I Pharynx Development Central Nervous System Development Blastocyst Development Microtubule Cytoskeleton Organization Forebrain Development Microtubule Organizing Center Organization Spindle Assembly Involved In Meiosis Epithelium Development Growth Protein Localization G2/M Transition Of Mitotic Cell Cycle Spindle Organization System Development Organ Development Spindle Stabilization Developmental Growth Involved In Morphogenesis Regulation Of Protein Stability Digestive Tract Development Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Cell Growth Organelle Organization Cellular Response To Indole-3-methanol Histone H3-K14 Acetylation Positive Regulation Of Cellular Protein Catabolic Process Digestive System Development Positive Regulation Of Axon Regeneration	Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Regulation Of RNA Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Nitrogen Compound Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription, DNA-templated Regulation Of Gene Expression Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Chromosome Organization Nitrogen Compound Metabolic Process Positive Regulation Of Cellular Metabolic Process Response To Stress Gene Expression Cell Cycle Chromatin Organization Transcription, DNA-templated Negative Regulation Of Transcription From RNA Polymerase II Promoter RNA Biosynthetic Process Chromatin Silencing At RDNA Regulation Of Cell Differentiation Transcription From RNA Polymerase II Promoter Positive Regulation Of Type I Interferon Production Organelle Organization Regulation Of Metabolic Process Immune System Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Positive Regulation Of Metabolic Process Regulation Of Type I Interferon Production Negative Regulation Of Cell Differentiation Chromatin Modification DNA Methylation On Cytosine Response To Abiotic Stimulus Regulation Of Histone Modification Chromatin Silencing Regulation Of Chromosome Organization
Tagcloud ?		acidic activating arrest centrosomal centrosome coil coiled death depletion details disrupting diverse g1 integrity lacking member p21 p38 p53 pharmacologically phosphorylated poorly require serine transforming triggered triggering tubulin vertebrates	acetyltransferase antiviral correlates cytoplasm dispensable enriched establish gcn5 h3k9 h3k9ac hat ifn ifnb immune immunity inhibiting innate instead kat2b pcaf production redundancy regulators repress surprisingly tbk1 triggers turn vast
Tagcloud (Difference) ?		acidic activating arrest centrosomal centrosome coil coiled death depletion details disrupting diverse g1 integrity lacking member p21 p38 p53 pharmacologically phosphorylated poorly require serine transforming triggered triggering tubulin vertebrates	acetyltransferase antiviral correlates cytoplasm dispensable enriched establish gcn5 h3k9 h3k9ac hat ifn ifnb immune immunity inhibiting innate instead kat2b pcaf production redundancy regulators repress surprisingly tbk1 triggers turn vast
Tagcloud (Intersection) ?