TACC3 and CDC20B

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		TACC3	CDC20B
Description		transforming acidic coiled-coil containing protein 3	cell division cycle 20B
Image			No pdb structure
GO Annotations	Cellular Component	Spindle Pole Cytoplasm Golgi Apparatus Centrosome Spindle Cytosol Cytoskeleton Centriolar Satellite Ciliary Basal Body Mitotic Spindle	Anaphase-promoting Complex Cytoplasm Deuterosome
	Molecular Function	Protein Binding	Protein Binding Anaphase-promoting Complex Binding Ubiquitin-protein Transferase Activator Activity Ubiquitin Ligase Activator Activity
	Biological Process	Microtubule Cytoskeleton Organization Mitotic Spindle Organization Metaphase/anaphase Transition Of Mitotic Cell Cycle Nuclear Migration Cerebral Cortex Development Cell Division Regulation Of Mitotic Spindle Organization Microtubule Cytoskeleton Organization Involved In Mitosis	Anaphase-promoting Complex-dependent Catabolic Process De Novo Centriole Assembly Positive Regulation Of Anaphase-promoting Complex-dependent Catabolic Process
Pathways		NOTCH3 Activation and Transmission of Signal to the Nucleus Negative regulation of NOTCH4 signaling
Drugs
Diseases
GWAS		Appendicular lean mass ( 33097823) Bladder cancer ( 20972438 24163127) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Hip circumference adjusted for BMI ( 34021172) Mean spheric corpuscular volume ( 32888494) Subcortical volume (MOSTest) ( 32665545) Urinary bladder cancer ( 20348956)	Cocaine dependence ( 31212010)
Interacting Genes		30 interacting genes: AKAP9 ARHGDIG ARNT ARNT2 ASPSCR1 AURKA BEX2 BEX3 CATSPERT CCHCR1 CDC20B CDKL5 CIB3 CLIP4 DRC10 EIF3C GDF15 KAT2A KIZ KLC1 KLHL38 NDEL1 NOD2 NUP54 RNF20 SNX20 SPATA18 TBC1D22B TTF2 VPS37C	21 interacting genes: CCDC57 FHL5 GEMIN4 GOLGA2 KANK2 KRT31 KRT34 KRT40 MAGEA11 MDFI MTUS2 NUTM1 PLEKHF2 PLK2 SPAG5 TACC3 TRAF2 TRIM23 TRIM27 TRIM37 VPS52
Entrez ID		10460	166979
HPRD ID		05601	13428
Ensembl ID		ENSG00000013810	ENSG00000164287
Uniprot IDs		A0A087WUE2 Q9Y6A5	Q86Y33
PDB IDs		5LXN 5LXO 5ODS 5ODT
Enriched GO Terms of Interacting Partners?		Cytoplasm Aryl Hydrocarbon Receptor Binding Aryl Hydrocarbon Receptor Complex Microtubule-based Process Mitotic Centrosome Separation Centrosome Localization Axon Hillock Centrosome Separation	Spindle Organization Cytoskeleton Organization Spindle Pole Cytoskeleton Structural Constituent Of Skin Epidermis Intermediate Filament Organization Mitotic Spindle Organization Microtubule Cytoskeleton Organization Intermediate Filament Cytoskeleton Organization Keratin Filament Intermediate Filament-based Process Ubiquitin-protein Transferase Activity Regulation Of Microtubule-based Process Establishment Of Localization In Cell Intracellular Transport Organelle Organization Regulation Of Cytoskeleton Organization Regulation Of Centriole Replication Microtubule Cytoskeleton Organization Involved In Mitosis Centriolar Satellite Mitotic Spindle Microtubule Nucleation Tumor Necrosis Factor Receptor Binding Ubiquitin Protein Ligase Activity Mitotic Cell Cycle Phase Transition Regulation Of Autophagy Intermediate Filament Cell Cycle Phase Transition Centrosome Positive Regulation Of Autophagy Embryonic Ectodermal Digestive Tract Development TORC2 Complex Disassembly Structural Molecule Activity Regulation Of Cell Cycle Cellular Localization Regulation Of Centrosome Duplication Regulation Of Cell Cycle Process Syntaxin Binding Microtubule-based Process Regulation Of Centrosome Cycle Regulation Of Organelle Organization TRAF2-GSTP1 Complex TORC1 Complex Assembly CD40 Receptor Binding Negative Regulation Of Vitamin D Receptor Signaling Pathway Supramolecular Fiber Organization Spindle Microtubule Binding Protein Autoubiquitination Regulation Of Organelle Assembly
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