TACC3 and TTF2

Number of citations of the paper that reports this interaction (PMID 12927788)
7

Data Source:
HPRD (two hybrid)

		TACC3	TTF2
Gene Name		transforming, acidic coiled-coil containing protein 3	transcription termination factor, RNA polymerase II
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Centrosome	Spliceosomal Complex Cytoplasm Transcription Elongation Factor Complex
	Molecular Function	Protein Binding Protein Domain Specific Binding	DNA Binding Protein Binding ATP Binding ATP-dependent Helicase Activity DNA-dependent ATPase Activity Zinc Ion Binding
	Biological Process	Microtubule Cytoskeleton Organization Response To Hypoxia Cell Proliferation Cerebral Cortex Development Neurogenesis Interkinetic Nuclear Migration Hemopoiesis Astral Microtubule Organization Regulation Of Microtubule-based Process Cytoplasmic Sequestering Of Transcription Factor Regulation Of Cell Cycle	DNA-templated Transcription, Termination Regulation Of Transcription, DNA-templated Termination Of RNA Polymerase II Transcription MRNA Processing RNA Splicing
Pathways
Drugs
Diseases
GWAS		Bladder cancer ( 20972438) Urinary bladder cancer ( 20348956)
Protein-Protein Interactions		13 interactors: AKAP9 ARNT2 ASPSCR1 AURKA CDH1 CIB3 KAT2A KIZ NDEL1 SNX20 TBC1D22B TTF2 VPS37C	22 interactors: CDC5L CDKL3 CLPB DCP1A DR1 DRAP1 HINFP HNRNPA1 HNRNPA2B1 KIF4A MATR3 MYB MYBL2 NVL PDCD6IP PRDX4 SKIL SMAD1 SMAD7 TACC3 TNIP1 ZSCAN1
Entrez ID		10460	8458
HPRD ID		05601	05280
Ensembl ID		ENSG00000013810
Uniprot IDs		Q9Y6A5	Q9UNY4
PDB IDs
Enriched GO Terms of Interacting Partners?		Mitotic Centrosome Separation Centrosome Separation Positive Regulation Of Metabolic Process Centrosome Localization In Utero Embryonic Development Cell Cycle Process Embryo Development Mitotic Cell Cycle Process Centrosome Cycle Cell Cycle Neuron Projection Extension Mitotic Cell Cycle Brain Development Mitotic Nuclear Division Chordate Embryonic Development Embryo Development Ending In Birth Or Egg Hatching Head Development Negative Regulation Of Spindle Checkpoint Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Membrane Organization Developmental Cell Growth Positive Regulation Of Cellular Metabolic Process Centrosome Organization Spindle Assembly Involved In Female Meiosis I Pharynx Development Central Nervous System Development Blastocyst Development Microtubule Cytoskeleton Organization Forebrain Development Microtubule Organizing Center Organization Spindle Assembly Involved In Meiosis Epithelium Development Growth Protein Localization G2/M Transition Of Mitotic Cell Cycle Spindle Organization System Development Organ Development Spindle Stabilization Developmental Growth Involved In Morphogenesis Regulation Of Protein Stability Digestive Tract Development Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Cell Growth Organelle Organization Cellular Response To Indole-3-methanol Histone H3-K14 Acetylation Positive Regulation Of Cellular Protein Catabolic Process Digestive System Development Positive Regulation Of Axon Regeneration	Gene Expression Regulation Of Transcription From RNA Polymerase II Promoter RNA Metabolic Process Heterocycle Metabolic Process Transcription, DNA-templated Negative Regulation Of Gene Expression RNA Biosynthetic Process Nucleobase-containing Compound Metabolic Process Nitrogen Compound Metabolic Process Cell Cycle Process Cellular Aromatic Compound Metabolic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Cellular Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process Macromolecule Biosynthetic Process Transcription From RNA Polymerase II Promoter Negative Regulation Of Biosynthetic Process Cell Cycle Regulation Of Cell Cycle Regulation Of Gene Expression Cellular Metabolic Process Mitotic Spindle Assembly Regulation Of Nitrogen Compound Metabolic Process Spindle Organization Negative Regulation Of Cellular Metabolic Process Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Cell Morphogenesis Involved In Differentiation Positive Regulation Of Dendrite Morphogenesis Cellular Response To Transforming Growth Factor Beta Stimulus Response To Transforming Growth Factor Beta Positive Regulation Of Transcription, DNA-templated Regulation Of Cell Morphogenesis Biosynthetic Process Mitotic Spindle Organization Positive Regulation Of Neuron Projection Development MRNA Metabolic Process MRNA Splicing, Via Spliceosome Negative Regulation Of Male Germ Cell Proliferation Modulation By Symbiont Of Host I-kappaB Kinase/NF-kappaB Cascade Response To Stress RNA Splicing, Via Transesterification Reactions Positive Regulation Of Dendrite Development Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
Tagcloud ?		acidic activating arrest centrosomal centrosome coil coiled death depletion details disrupting diverse g1 integrity lacking member p21 p38 p53 pharmacologically phosphorylated poorly require serine transforming triggered triggering tubulin vertebrates	away bidirectional coimmunoprecipitate cotranscriptional dcp1a dcp2 decapping edc3 elongation ends exonuclease facilitates localize nascent pause paused peaks pol premature productive redistribution seq shifted spt5 termination torpedo tss tsss xrn2
Tagcloud (Difference) ?		acidic activating arrest centrosomal centrosome coil coiled death depletion details disrupting diverse g1 integrity lacking member p21 p38 p53 pharmacologically phosphorylated poorly require serine transforming triggered triggering tubulin vertebrates	away bidirectional coimmunoprecipitate cotranscriptional dcp1a dcp2 decapping edc3 elongation ends exonuclease facilitates localize nascent pause paused peaks pol premature productive redistribution seq shifted spt5 termination torpedo tss tsss xrn2
Tagcloud (Intersection) ?