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ARHGEF3
Gene Name
Rho guanine nucleotide exchange factor (GEF) 3
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Intracellular
Cytosol
Molecular Function
Rho Guanyl-nucleotide Exchange Factor Activity
Biological Process
Small GTPase Mediated Signal Transduction
Rho Protein Signal Transduction
Positive Regulation Of Rho GTPase Activity
Positive Regulation Of Apoptotic Process
Neurotrophin TRK Receptor Signaling Pathway
Regulation Of Small GTPase Mediated Signal Transduction
Apoptotic Signaling Pathway
Pathways
Rho GTPase cycle
Signaling by GPCR
GPCR downstream signaling
Signalling by NGF
Cell death signalling via NRAGE, NRIF and NADE
Signaling by Rho GTPases
NRAGE signals death through JNK
G alpha (12/13) signalling events
p75 NTR receptor-mediated signalling
Drugs
Diseases
GWAS
Mean platelet volume (
22139419
19110211
19820697
)
Obesity-related traits (
23251661
)
Platelet counts (
22139419
23263863
)
Rheumatoid arthritis (
21452313
)
Protein-protein Interactions
5 interactors:
CEP70
RHOA
RHOB
TRIM23
TRIM27
Entrez ID
50650
HPRD ID
12480
Ensembl ID
ENSG00000163947
Uniprot IDs
E7EU49
E9PG37
Q9NR81
PDB IDs
Enriched GO Terms of Interacting Partners
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Rho Protein Signal Transduction
Small GTPase Mediated Signal Transduction
Cytokinesis
Negative Regulation Of Interleukin-2 Secretion
Skeletal Muscle Satellite Cell Migration
Platelet Activation
Positive Regulation Of Cytoskeleton Organization
Endosomal Transport
Cell Cycle Process
Ras Protein Signal Transduction
Negative Regulation Of Calcium Ion Import
Apolipoprotein A-I-mediated Signaling Pathway
Cleavage Furrow Formation
Transformed Cell Apoptotic Process
Positive Regulation Of Cellular Component Biogenesis
Cell Cycle
Interferon-gamma Secretion
Regulation Of Actin Cytoskeleton Organization
Axon Guidance
Positive Regulation Of Organelle Organization
Regulation Of Actin Filament-based Process
Blood Coagulation
Cell Division
Hemostasis
Negative Regulation Of Viral Release From Host Cell
Ossification Involved In Bone Maturation
Bone Maturation
Negative Chemotaxis
Mitotic Spindle Assembly
Interferon-gamma Production
Negative Regulation Of Interleukin-2 Production
Regulation Of Cytoskeleton Organization
Intracellular Signal Transduction
Negative Regulation Of Viral Transcription
Regulation Of Viral Release From Host Cell
Positive Regulation Of NF-kappaB Import Into Nucleus
Axonogenesis
Regulation Of Calcium Ion Import
Regulation Of Osteoblast Proliferation
Viral Process
Axon Development
Protein Ubiquitination
Regulation Of Body Fluid Levels
Cell Morphogenesis Involved In Neuron Differentiation
Wound Healing
Chemotaxis
Actin Cytoskeleton Organization
Protein Modification By Small Protein Conjugation
Endosome To Lysosome Transport
Regulation Of Protein Transport
Tagcloud
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