ARHGEF3 and TRIM23

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		ARHGEF3	TRIM23
Gene Name		Rho guanine nucleotide exchange factor (GEF) 3	tripartite motif containing 23
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Intracellular Cytosol	Golgi Membrane Nucleus Lysosomal Membrane Extracellular Vesicular Exosome
	Molecular Function	Rho Guanyl-nucleotide Exchange Factor Activity	GTPase Activity Ubiquitin-protein Transferase Activity Protein Binding GTP Binding Enzyme Activator Activity Zinc Ion Binding Ligase Activity GDP Binding Identical Protein Binding
	Biological Process	Small GTPase Mediated Signal Transduction Rho Protein Signal Transduction Positive Regulation Of Rho GTPase Activity Positive Regulation Of Apoptotic Process Neurotrophin TRK Receptor Signaling Pathway Regulation Of Small GTPase Mediated Signal Transduction Apoptotic Signaling Pathway	Small GTPase Mediated Signal Transduction Viral Process Protein Ubiquitination Positive Regulation Of Catalytic Activity
Pathways		Rho GTPase cycle Signaling by GPCR GPCR downstream signaling Signalling by NGF Cell death signalling via NRAGE, NRIF and NADE Signaling by Rho GTPases NRAGE signals death through JNK G alpha (12/13) signalling events p75 NTR receptor-mediated signalling
Drugs
Diseases
GWAS		Mean platelet volume ( 22139419 19110211 19820697) Obesity-related traits ( 23251661) Platelet counts ( 22139419 23263863) Rheumatoid arthritis ( 21452313)
Protein-Protein Interactions		5 interactors: CEP70 RHOA RHOB TRIM23 TRIM27	137 interactors: AKTIP ANKRD36BP1 AQP1 ARFGAP1 ARHGEF3 ARNT2 ATPAF2 ATXN7 BAG1 C10orf10 C19orf57 C8orf33 CARD9 CCDC146 CCDC25 CDC20B CDR2 CFAP53 COX5B CREB5 CXCL14 CYTH1 CYTH2 DCX DMC1 DMRT3 DOCK2 EAF2 EXOC3-AS1 FAM103A1 FAM110A FAM133A FAM193B FAM208B FAM83A FAM90A1 FBF1 FHIT FLAD1 FLJ38668 FXR2 GATA2 GEM GGA2 GMCL1P1 GPANK1 GPKOW HAUS1 HOXB5 HSPB7 IQCE IQUB JOSD1 KAT5 KIFC3 KLHL42 KRT6A LGALS8 LINC00526 LINC01018 LMO2 LNX1 LOC729603 MDM2 MKRN3 MLH1 MORN4 MRPL4 MRPL45 MTFR2 NEK6 NFU1 NXT2 PHF1 PIAS2 PIK3R2 PITX1 PKP4 POLI POLL POM121 PPIL2 PPP1R18 PSMA1 RAD18 RIBC2 RNF126 RNF213 RNF32 RNF34 RSRC2 RTP5 SF1 SH2D4A SIAH1 SLC25A6 SMG9 SNAI1 SNAI2 SNRPB SORBS3 SPG21 STK19 SUMO1P1 TBC1D22B TMSB4X TNFAIP3 TRAF1 TRAIP TRIM27 TRIM29 TRIM31 TRIM32 TRIM42 TROAP TSG101 TSHZ3 TXNDC5 UBC UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2E2 UBE2H UBE2I UBE2U UBOX5 USP2 USP20 USP21 UTP23 WDR25 ZC2HC1C ZNF250 ZNF564 ZNF581
Entrez ID		50650	373
HPRD ID		12480	03449
Ensembl ID		ENSG00000163947	ENSG00000113595
Uniprot IDs		E7EU49 E9PG37 Q9NR81	P36406
PDB IDs
Enriched GO Terms of Interacting Partners?		Rho Protein Signal Transduction Small GTPase Mediated Signal Transduction Cytokinesis Negative Regulation Of Interleukin-2 Secretion Skeletal Muscle Satellite Cell Migration Platelet Activation Positive Regulation Of Cytoskeleton Organization Endosomal Transport Cell Cycle Process Ras Protein Signal Transduction Negative Regulation Of Calcium Ion Import Apolipoprotein A-I-mediated Signaling Pathway Cleavage Furrow Formation Transformed Cell Apoptotic Process Positive Regulation Of Cellular Component Biogenesis Cell Cycle Interferon-gamma Secretion Regulation Of Actin Cytoskeleton Organization Axon Guidance Positive Regulation Of Organelle Organization Regulation Of Actin Filament-based Process Blood Coagulation Cell Division Hemostasis Negative Regulation Of Viral Release From Host Cell Ossification Involved In Bone Maturation Bone Maturation Negative Chemotaxis Mitotic Spindle Assembly Interferon-gamma Production Negative Regulation Of Interleukin-2 Production Regulation Of Cytoskeleton Organization Intracellular Signal Transduction Negative Regulation Of Viral Transcription Regulation Of Viral Release From Host Cell Positive Regulation Of NF-kappaB Import Into Nucleus Axonogenesis Regulation Of Calcium Ion Import Regulation Of Osteoblast Proliferation Viral Process Axon Development Protein Ubiquitination Regulation Of Body Fluid Levels Cell Morphogenesis Involved In Neuron Differentiation Wound Healing Chemotaxis Actin Cytoskeleton Organization Protein Modification By Small Protein Conjugation Endosome To Lysosome Transport Regulation Of Protein Transport	Protein Modification By Small Protein Conjugation Protein Ubiquitination Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein K48-linked Ubiquitination Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Cellular Macromolecule Catabolic Process Negative Regulation Of Cellular Metabolic Process Cellular Metabolic Process Cellular Protein Modification Process Cellular Protein Metabolic Process Regulation Of Protein Catabolic Process Proteolysis Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Apoptotic Process Programmed Cell Death Regulation Of Metabolic Process Cellular Response To Stress Positive Regulation Of Metabolic Process Cell Death Death Gene Expression RNA Biosynthetic Process Transcription, DNA-templated Negative Regulation Of RNA Biosynthetic Process Catabolic Process Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Gene Expression Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of Biosynthetic Process RNA Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Cellular Response To Hypoxia Protein Metabolic Process Cellular Response To Decreased Oxygen Levels Regulation Of Transcription, DNA-templated Regulation Of Proteolysis Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Cellular Response To Oxygen Levels Regulation Of Cellular Protein Metabolic Process Nucleobase-containing Compound Metabolic Process
Tagcloud ?			344r abrogated adaptor antiviral conjugation defense e3 ectopic embryo helicase ikkgamma innate irf3 k165 k27 lys mda5 modulator multipoints nemo polyubiquitination rig substantially tightly tlr3 tlrs toll triparite ubiquitin
Tagcloud (Difference) ?			344r abrogated adaptor antiviral conjugation defense e3 ectopic embryo helicase ikkgamma innate irf3 k165 k27 lys mda5 modulator multipoints nemo polyubiquitination rig substantially tightly tlr3 tlrs toll triparite ubiquitin
Tagcloud (Intersection) ?