ARHGEF3 and TRIM23

Number of citations of the paper that reports this interaction (PubMedID 29892012)
71

Data Source:
BioGRID (two hybrid)

		ARHGEF3	TRIM23
Description		Rho guanine nucleotide exchange factor 3	tripartite motif containing 23
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol	Golgi Membrane Nucleus Cytoplasm Lysosome Lysosomal Membrane Golgi Apparatus Plasma Membrane Endomembrane System Membrane
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Protein Binding	Nucleotide Binding GTPase Activity Ubiquitin-protein Transferase Activity Protein Binding GTP Binding Enzyme Activator Activity Zinc Ion Binding Transferase Activity GDP Binding Identical Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Rho Protein Signal Transduction Positive Regulation Of Rho Protein Signal Transduction Intracellular Signal Transduction Regulation Of Small GTPase Mediated Signal Transduction	Immune System Process Intracellular Protein Transport Positive Regulation Of Autophagy Vesicle-mediated Transport Protein Ubiquitination Innate Immune Response
Pathways		NRAGE signals death through JNK G alpha (12/13) signalling events RHOA GTPase cycle RHOB GTPase cycle
Drugs
Diseases
GWAS		Asthma ( 32296059) Attention function in attention deficit hyperactive disorder ( 26174813) Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes ( 29221444) Glaucoma (primary open-angle) ( 33627673) Height ( 28552196) Hematocrit ( 32888494) Hemoglobin ( 32888494) Hemoglobin levels ( 32327693) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Hip circumference adjusted for BMI ( 34021172) Idiopathic dilated cardiomyopathy ( 29495422) Lymphocyte count ( 27863252 32888494) Lymphocyte percentage of white cells ( 32888494) Mean arterial pressure ( 27618448) Mean platelet volume ( 19110211 19820697 32888494 22139419 24026423 31194788 27863252 28031487) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Multiple sclerosis ( 31604244) Multiple sclerosis and triglyceride levels (pleiotropy) ( 26920376) Obesity-related traits ( 23251661) Platelet count ( 22139419 32888494 27863252 29066854 23263863 28031487 26805783 29403010 24026423) Platelet distribution width ( 32888494) Plateletcrit ( 27863252 32888494) Refractive error ( 32231278) Reticulocyte count ( 27863252 32888494) Reticulocyte fraction of red cells ( 27863252 32888494) Rheumatoid arthritis ( 21452313) Systolic blood pressure ( 30578418)	Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		9 interacting genes: CEP70 HSF2BP PBX4 PICK1 RHOA RHOB TERF1 TRIM23 TRIM27	219 interacting genes: ACTN4 AKTIP ANKRD36BP1 ANKRD55 ANO1 AP3M1 AQP1 ARFGAP1 ARHGEF3 ARNT2 ATPAF2 ATXN7 BAG1 BAZ2B BICRAL BRME1 C8orf33 CARD9 CATSPERT CBX8 CCDC13 CCDC146 CCDC25 CCDC33 CDC20B CDC73 CDR2 CFAP53 CHP1P2 CIMIP4 COX5B CPNE7 CREB5 CSRP2 CWF19L2 CXCL14 CYTH1 CYTH2 DCX DEPP1 DMC1 DMRT3 DNAAF4 DOCK2 EAF2 EHHADH EIF3D ENKD1 EPN2 EXOC3-AS1 FAM110A FAM133A FAM193B FAM83A FAM90A1 FBF1 FHIT FLAD1 FXR2 GAD1 GATA2 GCC2-AS1 GEM GGA2 GGA3 GLIDR GMCL2 GPANK1 GPKOW HAPLN2 HAUS1 HGS HNRNPLL HOXB5 HSPB7 IL16 IQCE IQUB JOSD1 JRK KAT5 KIFC3 KLHL42 KRT6A KRT75 KRT76 LAGE3 LENG1 LGALS14 LGALS3 LGALS8 LINC00526 LINC01018 LMO2 LMO3 LNX1 MDM2 MKRN3 MLH1 MORN4 MRPL4 MRPL45 MSRB3 MTFR2 MYEF2 MYOM1 MYOZ1 NAB2 NEDD9 NEK6 NFU1 NOXA1 NTAQ1 NUDT21 NXT2 PDE4D PHF1 PIAS2 PIK3R2 PITX1 PKP4 PLEKHA2 POLI POLL POM121 PPIL2 PPP1R15B PPP1R18 PRPF18 PRPF31 PSMA1 PSMB1 RAD18 RAMAC RCAN3 RIBC1 RIBC2 RIN1 RNF126 RNF213 RNF32 RNF34 RNF6 RSRC2 RTP5 RUFY1 SCNM1 SF1 SH2D4A SIAH1 SIRPA SLC25A6 SMG9 SNAI1 SNAI2 SNRPB SNRPB2 SNW1 SORBS3 SPG21 SUMO1P1 TACO1 TASOR2 TBC1D22B TCEA2 TCEANC TEPSIN TMSB4X TNFAIP3 TRAF1 TRAIP TRIM27 TRIM29 TRIM31 TRIM32 TRIM42 TRIM55 TRIM63 TROAP TSEN54 TSG101 TSHZ3 TXNDC5 UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2H UBE2I UBE2L3 UBE2N UBE2U UBE2W UBOX5 UBQLN1 USP2 USP20 USP21 UTP23 VGLL1 WDR25 WHR1 ZBTB16 ZBTB4 ZC2HC1C ZFAND2A ZNF20 ZNF250 ZNF408 ZNF417 ZNF474 ZNF564 ZNF581 ZNF587 ZNF688 ZNF835
Entrez ID		50650	373
HPRD ID		12480	03449
Ensembl ID		ENSG00000163947	ENSG00000113595
Uniprot IDs		B7Z6B2 B7Z7T8 C9J586 E9PG37 Q9NR81	P36406
PDB IDs			5VZV 5VZW
Enriched GO Terms of Interacting Partners?		Endothelial Tube Morphogenesis Regulation Of Modification Of Postsynaptic Structure Regulation Of Modification Of Synaptic Structure Regulation Of Cytoskeleton Organization Regulation Of Organelle Organization Regulation Of Actin Nucleation GTPase Activity Regulation Of Cellular Component Organization Rho Protein Signal Transduction Actin Filament Organization Mitotic Cytokinesis Regulation Of Actin Filament Organization Angiotensin-mediated Vasoconstriction Involved In Regulation Of Systemic Arterial Blood Pressure Cleavage Furrow Mitotic Cleavage Furrow Formation Negative Regulation Of Establishment Of Protein Localization To Telomere Negative Regulation Of Establishment Of Protein-containing Complex Localization To Telomere Negative Regulation Of Establishment Of RNA Localization To Telomere Positive Regulation Of Shelterin Complex Assembly Identical Protein Binding GTP Binding GDP Binding Aortic Valve Formation Regulation Of Actin Cytoskeleton Organization Regulation Of Supramolecular Fiber Organization Cytoskeleton-dependent Cytokinesis Positive Regulation Of Vascular Associated Smooth Muscle Contraction Endothelial Tube Lumen Extension Regulation Of Actin Filament-based Process Skeletal Muscle Satellite Cell Migration Negative Regulation Of Telomeric D-loop Disassembly Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Epithelial Tube Morphogenesis Beta Selection Supramolecular Fiber Organization Positive Regulation Of Cellular Component Organization Positive Regulation Of Organelle Organization Bone Trabecula Morphogenesis Membrane Curvature Sensor Activity Intracellular Transport Intracellular Protein Transport Apolipoprotein A-I-mediated Signaling Pathway Roundabout Signaling Pathway Regulation Of Microtubule Cytoskeleton Organization Regulation Of Systemic Arterial Blood Pressure By Endothelin Forebrain Radial Glial Cell Differentiation Fibrillar Center Regulation Of Establishment Of Protein Localization To Telomere Shelterin Complex Negative Regulation Of Arp2/3 Complex-mediated Actin Nucleation	Protein Binding Protein Polyubiquitination Ubiquitin Conjugating Enzyme Activity Protein Modification By Small Protein Conjugation Post-translational Protein Modification Protein Ubiquitination Ubiquitin-protein Transferase Activity Modification-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Protein K48-linked Ubiquitination Nucleus Ubiquitin Protein Ligase Activity Proteolysis Involved In Protein Catabolic Process Protein K63-linked Ubiquitination Zinc Ion Binding Protein Modification Process Ubiquitin-protein Transferase Activator Activity Macromolecule Catabolic Process Protein Monoubiquitination Proteolysis Ubiquitin Protein Ligase Binding Protein K11-linked Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Ubiquitin Binding SUMO Transferase Activity Spliceosomal Complex Nuclear Speck Proteasomal Protein Catabolic Process Macromolecule Metabolic Process Establishment Of Protein Localization To Vacuole MRNA Processing Spindle Pole Identical Protein Binding Protein Metabolic Process Metal Ion Binding SnRNP Binding Negative Regulation Of Toll-like Receptor 3 Signaling Pathway Striated Muscle Myosin Thick Filament Cytoplasm Protein Sumoylation
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