ARHGEF3 and TERF1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		ARHGEF3	TERF1
Description		Rho guanine nucleotide exchange factor 3	telomeric repeat binding factor 1
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol	Chromosome, Telomeric Region Nuclear Telomere Cap Complex Fibrillar Center Nucleus Nucleoplasm Chromosome Nucleolus Cytoplasm Spindle Cytoskeleton Nuclear Body Shelterin Complex
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Protein Binding	DNA Binding Double-stranded Telomeric DNA Binding Telomerase Activity Protein Binding Microtubule Binding DNA Binding, Bending Telomeric DNA Binding Identical Protein Binding Protein Homodimerization Activity Ankyrin Repeat Binding G-rich Strand Telomeric DNA Binding
	Biological Process	Rho Protein Signal Transduction Positive Regulation Of Rho Protein Signal Transduction Intracellular Signal Transduction Regulation Of Small GTPase Mediated Signal Transduction	Telomere Maintenance Telomere Maintenance Via Telomerase Negative Regulation Of DNA Replication Response To Xenobiotic Stimulus Telomere Capping Positive Regulation Of Telomere Maintenance Negative Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Meiotic Telomere Clustering Cell Division Telomeric D-loop Disassembly T-circle Formation Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Positive Regulation Of Shelterin Complex Assembly Negative Regulation Of Establishment Of Protein Localization To Telomere Negative Regulation Of Establishment Of RNA Localization To Telomere Negative Regulation Of Establishment Of Protein-containing Complex Localization To Telomere Negative Regulation Of Telomeric D-loop Disassembly
Pathways		NRAGE signals death through JNK G alpha (12/13) signalling events RHOA GTPase cycle RHOB GTPase cycle	Recognition and association of DNA glycosylase with site containing an affected pyrimidine Cleavage of the damaged pyrimidine Recognition and association of DNA glycosylase with site containing an affected purine Recognition and association of DNA glycosylase with site containing an affected purine Cleavage of the damaged purine Cleavage of the damaged purine Meiotic synapsis Packaging Of Telomere Ends Telomere Extension By Telomerase Polymerase switching on the C-strand of the telomere Processive synthesis on the C-strand of the telomere Telomere C-strand (Lagging Strand) Synthesis Telomere C-strand synthesis initiation Removal of the Flap Intermediate from the C-strand DNA Damage/Telomere Stress Induced Senescence Inhibition of DNA recombination at telomere
Drugs
Diseases
GWAS		Asthma ( 32296059) Attention function in attention deficit hyperactive disorder ( 26174813) Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes ( 29221444) Glaucoma (primary open-angle) ( 33627673) Height ( 28552196) Hematocrit ( 32888494) Hemoglobin ( 32888494) Hemoglobin levels ( 32327693) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Hip circumference adjusted for BMI ( 34021172) Idiopathic dilated cardiomyopathy ( 29495422) Lymphocyte count ( 27863252 32888494) Lymphocyte percentage of white cells ( 32888494) Mean arterial pressure ( 27618448) Mean platelet volume ( 19110211 19820697 32888494 22139419 24026423 31194788 27863252 28031487) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Multiple sclerosis ( 31604244) Multiple sclerosis and triglyceride levels (pleiotropy) ( 26920376) Obesity-related traits ( 23251661) Platelet count ( 22139419 32888494 27863252 29066854 23263863 28031487 26805783 29403010 24026423) Platelet distribution width ( 32888494) Plateletcrit ( 27863252 32888494) Refractive error ( 32231278) Reticulocyte count ( 27863252 32888494) Reticulocyte fraction of red cells ( 27863252 32888494) Rheumatoid arthritis ( 21452313) Systolic blood pressure ( 30578418)	Age at first sexual intercourse ( 34211149) Crohn's disease ( 22412388) Leukocyte telomere length ( 31171785) Telomere length ( 33941849)
Interacting Genes		9 interacting genes: CEP70 HSF2BP PBX4 PICK1 RHOA RHOB TERF1 TRIM23 TRIM27	212 interacting genes: ACAT2 ACOT7 ACY1 AFAP1L2 AHCY AK1 AKR1A1 ALDOA AMPD2 AMPH ANXA2 ANXA5 ANXA8L1 APEX1 ARHGDIA ARHGEF3 ARPP21 ASS1 ATM BCL7B BIN2 BLM BRAF C12orf43 C1orf35 CALD1 CAPNS1 CASP7 CCDC9 CDC6 CDK1 CEP85 CFL1 CKB CORO1B CPNE3 CRYBB1 CRYM DBN1 DBNL DCX DDX19B DDX21 DDX23 DDX24 DDX39A DLG5 DNAAF11 DNAJB1 DNPH1 DPP3 DPYSL3 EEF1D EIF4B ENO2 EPB41L1 EPHX2 EVL FANCD2 FBP1 FBXO4 FEN1 FES FKBP8 GAMT GAPDH GIT1 GNL3L GNMT GSS H1-1 HCLS1 HDGFL2 HEXIM1 HEXIM2 HGD HMGN3 HMGN4 HMOX1 HNMT HOXA3 HSP90AB1 HSPA6 IPO5 JSRP1 KCTD7 KDM1A KEAP1 KIFBP KLHDC4 KPNB1 LASP1 LDHA LDHB LRSAM1 LYAR MAP4 MAP7 MAPK12 MAPRE1 MCM2 MDH1 MISP MSN MT1X MVK NAP1L1 NBN NEFL NEK7 NME1 NME2 NOL12 NOL3 NRIP1 NUDCD2 NUDT14 NUMA1 NXNL1 OCM2 OGFR OGT PA2G4 PACSIN2 PAFAH1B3 PAGE2 PAICS PAK4 PCLAF PCP4 PEPD PFKP PFN2 PGD PGLS PGM1 PGM2 PINX1 PKM PNMT POT1 PPM1G PRDX1 PRDX6 PRKCB PTMA PTPN5 RBMY1A1 RECQL4 RIC8A RLIM RNF10 RPAP3 RPL19 RTN3 RTN4 SALL1 SARS1 SBDS SENP8 SET SH3BP1 SH3GL2 SH3GL3 SHFL SIRPD SKP1 SMAD9 SMARCC2 SNCG SOAT1 SP100 SRM SRSF6 STUB1 SULT1C2 SUPT5H SYK TALDO1 TBC1D10A TBCD TBL1X TCIRG1 TERT THG1L TINAG TINF2 TKT TMSB10 TMSB4Y TNKS TNKS2 TNPO2 TOMM34 TPI1 TRIM16 TRIP10 TRMT1 TUBB2A TUBB3 TUBB4B UBE2M UTP14A WARS1 WDR4 WFS1 YWHAG ZBTB16 ZC3H18 ZFP36L1 ZHX1 ZNF790
Entrez ID		50650	7013
HPRD ID		12480	02975
Ensembl ID		ENSG00000163947	ENSG00000147601
Uniprot IDs		B7Z6B2 B7Z7T8 C9J586 E9PG37 Q9NR81	A0A7I2V5T5 A0A7I2YQE7 P54274
PDB IDs			1BA5 1H6O 1ITY 1IV6 1W0T 3BQO 3L82 5HKP 5WIR 5XUP 8F0A 8F0U 8F1T 8F1U 8F21 8F26 8OX1 8W8G
Enriched GO Terms of Interacting Partners?		Endothelial Tube Morphogenesis Regulation Of Modification Of Postsynaptic Structure Regulation Of Modification Of Synaptic Structure Regulation Of Cytoskeleton Organization Regulation Of Organelle Organization Regulation Of Actin Nucleation GTPase Activity Regulation Of Cellular Component Organization Rho Protein Signal Transduction Actin Filament Organization Mitotic Cytokinesis Regulation Of Actin Filament Organization Angiotensin-mediated Vasoconstriction Involved In Regulation Of Systemic Arterial Blood Pressure Cleavage Furrow Mitotic Cleavage Furrow Formation Negative Regulation Of Establishment Of Protein Localization To Telomere Negative Regulation Of Establishment Of Protein-containing Complex Localization To Telomere Negative Regulation Of Establishment Of RNA Localization To Telomere Positive Regulation Of Shelterin Complex Assembly Identical Protein Binding GTP Binding GDP Binding Aortic Valve Formation Regulation Of Actin Cytoskeleton Organization Regulation Of Supramolecular Fiber Organization Cytoskeleton-dependent Cytokinesis Positive Regulation Of Vascular Associated Smooth Muscle Contraction Endothelial Tube Lumen Extension Regulation Of Actin Filament-based Process Skeletal Muscle Satellite Cell Migration Negative Regulation Of Telomeric D-loop Disassembly Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Epithelial Tube Morphogenesis Beta Selection Supramolecular Fiber Organization Positive Regulation Of Cellular Component Organization Positive Regulation Of Organelle Organization Bone Trabecula Morphogenesis Membrane Curvature Sensor Activity Intracellular Transport Intracellular Protein Transport Apolipoprotein A-I-mediated Signaling Pathway Roundabout Signaling Pathway Regulation Of Microtubule Cytoskeleton Organization Regulation Of Systemic Arterial Blood Pressure By Endothelin Forebrain Radial Glial Cell Differentiation Fibrillar Center Regulation Of Establishment Of Protein Localization To Telomere Shelterin Complex Negative Regulation Of Arp2/3 Complex-mediated Actin Nucleation	Cytosol Cytoplasm Extracellular Exosome Identical Protein Binding Protein Binding Nucleobase-containing Compound Metabolic Process Nicotinamide Nucleotide Metabolic Process Telomere Maintenance Chromosome, Telomeric Region Nucleobase-containing Small Molecule Metabolic Process Purine-containing Compound Metabolic Process Telomere Organization Cadherin Binding Nucleus Negative Regulation Of Telomere Maintenance Purine Nucleotide Metabolic Process ADP Metabolic Process Regulation Of Telomere Maintenance Via Telomerase Regulation Of Chromosome Organization Positive Regulation Of Chromosome Organization Nucleoside Diphosphate Metabolic Process Glycolytic Process Pyruvate Metabolic Process Positive Regulation Of Cellular Component Organization Regulation Of Cellular Component Organization ADP Catabolic Process Nucleotide Metabolic Process Purine Ribonucleoside Diphosphate Catabolic Process Regulation Of Telomere Maintenance Via Telomere Lengthening Ribonucleoside Diphosphate Catabolic Process Nucleoside Phosphate Metabolic Process Ficolin-1-rich Granule Lumen Nucleoside Diphosphate Catabolic Process Ribonucleoside Diphosphate Metabolic Process Nucleoside Phosphate Catabolic Process RNA Binding Phosphate-containing Compound Metabolic Process Microtubule Cytoskeleton Organization Negative Regulation Of DNA Metabolic Process Regulation Of Telomere Maintenance Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Purine Nucleotide Catabolic Process Protein Localization To Organelle Positive Regulation Of Protein-containing Complex Assembly Cytoskeleton Positive Regulation Of Organelle Organization Organelle Organization Catalytic Activity Small Molecule Metabolic Process Organophosphate Catabolic Process
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