ARHGEF3 and RHOB

Number of citations of the paper that reports this interaction (PMID 12221096)
37

Data Source:
HPRD (in vivo)

		ARHGEF3	RHOB
Gene Name		Rho guanine nucleotide exchange factor (GEF) 3	ras homolog family member B
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Intracellular Cytosol	Nucleus Early Endosome Cytosol Plasma Membrane Focal Adhesion Endosome Membrane Late Endosome Membrane Cleavage Furrow Extracellular Vesicular Exosome
	Molecular Function	Rho Guanyl-nucleotide Exchange Factor Activity	GTPase Activity Protein Binding GTP Binding GDP Binding
	Biological Process	Small GTPase Mediated Signal Transduction Rho Protein Signal Transduction Positive Regulation Of Rho GTPase Activity Positive Regulation Of Apoptotic Process Neurotrophin TRK Receptor Signaling Pathway Regulation Of Small GTPase Mediated Signal Transduction Apoptotic Signaling Pathway	Cytokinesis Angiogenesis Intracellular Protein Transport Apoptotic Process Transformed Cell Apoptotic Process Cell Adhesion Small GTPase Mediated Signal Transduction Rho Protein Signal Transduction Axon Guidance Blood Coagulation Metabolic Process Endosome To Lysosome Transport Platelet Activation Positive Regulation Of Apoptotic Process Positive Regulation Of Angiogenesis Negative Regulation Of Cell Cycle Regulation Of Small GTPase Mediated Signal Transduction Cellular Response To Hydrogen Peroxide Cellular Response To Ionizing Radiation
Pathways		Rho GTPase cycle Signaling by GPCR GPCR downstream signaling Signalling by NGF Cell death signalling via NRAGE, NRIF and NADE Signaling by Rho GTPases NRAGE signals death through JNK G alpha (12/13) signalling events p75 NTR receptor-mediated signalling	Rho GTPase cycle Signaling by GPCR GPCR downstream signaling Axon guidance Semaphorin interactions Signaling by Rho GTPases GPVI-mediated activation cascade G alpha (12/13) signalling events Sema4D in semaphorin signaling Platelet activation, signaling and aggregation Sema4D induced cell migration and growth-cone collapse
Drugs
Diseases
GWAS		Mean platelet volume ( 22139419 19110211 19820697) Obesity-related traits ( 23251661) Platelet counts ( 22139419 23263863) Rheumatoid arthritis ( 21452313)	Systemic sclerosis ( 21750679)
Protein-Protein Interactions		5 interactors: CEP70 RHOA RHOB TRIM23 TRIM27	9 interactors: ARHGDIG ARHGEF3 CIT FNTA PDE6D PGGT1B PPP2CA RHPN2 TNFAIP1
Entrez ID		50650	388
HPRD ID		12480	01321
Ensembl ID		ENSG00000163947	ENSG00000143878
Uniprot IDs		E7EU49 E9PG37 Q9NR81	P62745
PDB IDs			2FV8
Enriched GO Terms of Interacting Partners?		Rho Protein Signal Transduction Small GTPase Mediated Signal Transduction Cytokinesis Negative Regulation Of Interleukin-2 Secretion Skeletal Muscle Satellite Cell Migration Platelet Activation Positive Regulation Of Cytoskeleton Organization Endosomal Transport Cell Cycle Process Ras Protein Signal Transduction Negative Regulation Of Calcium Ion Import Apolipoprotein A-I-mediated Signaling Pathway Cleavage Furrow Formation Transformed Cell Apoptotic Process Positive Regulation Of Cellular Component Biogenesis Cell Cycle Interferon-gamma Secretion Regulation Of Actin Cytoskeleton Organization Axon Guidance Positive Regulation Of Organelle Organization Regulation Of Actin Filament-based Process Blood Coagulation Cell Division Hemostasis Negative Regulation Of Viral Release From Host Cell Ossification Involved In Bone Maturation Bone Maturation Negative Chemotaxis Mitotic Spindle Assembly Interferon-gamma Production Negative Regulation Of Interleukin-2 Production Regulation Of Cytoskeleton Organization Intracellular Signal Transduction Negative Regulation Of Viral Transcription Regulation Of Viral Release From Host Cell Positive Regulation Of NF-kappaB Import Into Nucleus Axonogenesis Regulation Of Calcium Ion Import Regulation Of Osteoblast Proliferation Viral Process Axon Development Protein Ubiquitination Regulation Of Body Fluid Levels Cell Morphogenesis Involved In Neuron Differentiation Wound Healing Chemotaxis Actin Cytoskeleton Organization Protein Modification By Small Protein Conjugation Endosome To Lysosome Transport Regulation Of Protein Transport	Protein Geranylgeranylation Protein Prenylation Regulation Of Catalytic Activity Response To Stimulus Rho Protein Signal Transduction Apoptotic Process Programmed Cell Death Positive Regulation Of Tubulin Deacetylation Cell Death Death Regulation Of Metabolic Process Negative Regulation Of Cell Morphogenesis Involved In Differentiation Regulation Of Receptor Activity Regulation Of DNA Replication Cellular Response To Growth Factor Stimulus Response To Growth Factor Negative Regulation Of Nitric-oxide Synthase Biosynthetic Process Protein Farnesylation Positive Regulation Of Catalytic Activity Regulation Of Signal Transduction Regulation Of Tubulin Deacetylation Negative Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Positive Regulation Of Deacetylase Activity Regulation Of Small GTPase Mediated Signal Transduction Regulation Of Intracellular Signal Transduction Neurotransmitter Receptor Metabolic Process Regulation Of Signaling Ras Protein Signal Transduction Metaphase/anaphase Transition Of Mitotic Cell Cycle Negative Regulation Of Dendrite Morphogenesis Cellular Macromolecule Catabolic Process Intracellular Signal Transduction Cellular Protein Modification Process Mitotic Nuclear Envelope Reassembly Enzyme Linked Receptor Protein Signaling Pathway Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Protein Heterotrimerization Nuclear Envelope Reassembly Positive Regulation Of Metabolic Process Positive Regulation Of Cell Cycle Signal Transduction Stress Fiber Assembly Positive Regulation Of Hydrolase Activity Negative Regulation Of Dendrite Development Regulation Of Rho Protein Signal Transduction Negative Regulation Of Cell Development Signaling Negative Regulation Of Epithelial To Mesenchymal Transition Cell Communication
Tagcloud ?			addiction belongs compromised cytoskeletal epilepsy glioblastoma glioma gtpase homologs inversely limiting nononcogene p21cip1 phenotypes retaining rhoa rhoc scarcity spheroid stat3 trafficking tumorigenic v14 vast vesicle waf1 xenograft xenografts
Tagcloud (Difference) ?			addiction belongs compromised cytoskeletal epilepsy glioblastoma glioma gtpase homologs inversely limiting nononcogene p21cip1 phenotypes retaining rhoa rhoc scarcity spheroid stat3 trafficking tumorigenic v14 vast vesicle waf1 xenograft xenografts
Tagcloud (Intersection) ?