DNTTIP2 and RNF8

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		DNTTIP2	RNF8
Description		deoxynucleotidyltransferase terminal interacting protein 2	ring finger protein 8
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Chromosome Nucleolus Small-subunit Processome	Ubiquitin Ligase Complex Chromosome, Telomeric Region Nucleus Nucleoplasm Chromosome Cytoplasm Cytosol Midbody Site Of Double-strand Break
	Molecular Function	RNA Binding Protein Binding	Chromatin Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Ubiquitin Protein Ligase Binding Histone Binding Identical Protein Binding Protein Homodimerization Activity Ubiquitin Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	RNA Processing Ribosomal Small Subunit Biogenesis	DNA Repair Double-strand Break Repair Double-strand Break Repair Via Nonhomologous End Joining Chromatin Organization Ubiquitin-dependent Protein Catabolic Process DNA Damage Response Response To Ionizing Radiation Protein Ubiquitination Negative Regulation Of Transcription Elongation By RNA Polymerase II Sperm DNA Condensation Interstrand Cross-link Repair Epigenetic Regulation Of Gene Expression Signal Transduction In Response To DNA Damage Isotype Switching Positive Regulation Of DNA Repair Cell Division Protein Autoubiquitination Protein K63-linked Ubiquitination Protein K48-linked Ubiquitination Protein K6-linked Ubiquitination DNA Repair-dependent Chromatin Remodeling Positive Regulation Of Double-strand Break Repair Via Homologous Recombination Protein Localization To Site Of Double-strand Break
Pathways			Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Nonhomologous End-Joining (NHEJ) Processing of DNA double-strand break ends G2/M DNA damage checkpoint
Drugs
Diseases
GWAS		Gut microbiota alpha diversity (PD_whole_tree index) ( 33208821) Serum polyunsaturated fatty acid concentration x sex interaction in metabolic syndrome ( 31991592)	Acne (severe) ( 24927181) Restless legs syndrome ( 29029846)
Interacting Genes		18 interacting genes: CAVIN1 CEP70 DNTT ESR1 ESR2 H2AC25 H2BC1 H3C15 H4C16 PCNA PICK1 PPARG RBPMS RNF10 RNF8 RXRA SPP1 TULP3	78 interacting genes: AMOTL2 BLM CALCOCO1 CATSPERT CCDC14 CCDC50 CCDC85B CEP44 CEP85 CFLAR CHD4 CHEK2 CLK2 CLK3 DNM2 DNTTIP2 EPN2 EPN3 EXOSC2 FAM9B FSD2 GPRASP2 H2AC20 H2AC4 H2AX H2BC21 H2BC3 HOMEZ JMJD1C KDM4A KIF24 KMT5A KRTAP10-1 KRTAP10-8 KRTAP9-2 KRTAP9-8 LMO4 MAD1L1 MAGED1 MAPK1 MDC1 MDM2 NONO PCYT1A PGRMC2 PICK1 PNMA2 POLD4 RBFOX2 RECQL4 RXRA RYBP SCN3B SEPTIN3 SH3GL3 STX11 SUMO2 SUMO3 TMEM79 TNIP1 TOMM20L TRIM29 UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2E2 UBE2E3 UBE2N UBE2V2 UBE2W VCP WASL XRN2 YEATS4 ZBTB10 ZNF346 ZNF496
Entrez ID		30836	9025
HPRD ID		09994	11521
Ensembl ID		ENSG00000067334	ENSG00000112130
Uniprot IDs		Q5QJE6	O76064
PDB IDs		7MQ8 7MQ9 7MQA	2CSW 2PIE 4AYC 4ORH 4WHV
Enriched GO Terms of Interacting Partners?		Nuclear Receptor Activity DNA Binding Enzyme Binding Nuclear Steroid Receptor Activity Structural Constituent Of Chromatin Nuclear Receptor-mediated Signaling Pathway Nuclear Estrogen Receptor Activity DNA Binding Domain Binding Nucleosome Nucleosome Organization Transcription Coregulator Binding Positive Regulation Of Lipoprotein Transport Nucleoplasm Chromatin Organization Hormone-mediated Signaling Pathway LBD Domain Binding Identical Protein Binding Chromosome, Telomeric Region Chromatin Remodeling Protein-DNA Complex Assembly Chromatin Regulation Of DNA-templated Transcription Estrogen Response Element Binding Steroid Hormone Receptor Signaling Pathway Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Regulation Of RNA Biosynthetic Process Peroxisome Proliferator Activated Receptor Signaling Pathway Positive Regulation Of Nucleobase-containing Compound Metabolic Process Nucleus Intracellular Receptor Signaling Pathway Positive Regulation Of Lipid Transport Chromatin Binding Response To Lipid Regulation Of RNA Metabolic Process Nucleobase-containing Compound Biosynthetic Process Negative Regulation Of DNA-templated Transcription Protein Localization To Chromosome Monocyte Differentiation Sperm DNA Condensation Nucleosome Disassembly Nucleosome Assembly Response To Estradiol Negative Regulation Of RNA Biosynthetic Process Protein-DNA Complex Disassembly Estrogen Receptor Signaling Pathway Retinoic Acid Receptor Signaling Pathway Negative Regulation Of Transcription By RNA Polymerase II Androgen Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Metabolic Process	Ubiquitin Conjugating Enzyme Activity Nucleus Protein Polyubiquitination Nucleoplasm DNA Damage Response DNA Repair Protein Modification By Small Protein Conjugation Protein Monoubiquitination Protein Ubiquitination DNA Metabolic Process Post-translational Protein Modification Protein K63-linked Ubiquitination Protein Binding Identical Protein Binding Ubiquitin-protein Transferase Activity Negative Regulation Of Biosynthetic Process Protein Modification Process Double-strand Break Repair Protein K48-linked Ubiquitination Regulation Of Nucleobase-containing Compound Metabolic Process Chromosome DNA Recombination Negative Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Chromosome, Telomeric Region Nucleosome Negative Regulation Of Membrane Tubulation Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process Protein K11-linked Ubiquitination Double-strand Break Repair Via Homologous Recombination Negative Regulation Of Macromolecule Metabolic Process Recombinational Repair Structural Constituent Of Chromatin DNA/DNA Annealing Activity Regulation Of Double-strand Break Repair UBC13-MMS2 Complex Cellular Response To Stress Ubiquitin Protein Ligase Binding Positive Regulation Of Protein Polyubiquitination Regulation Of Metabolic Process Positive Regulation Of Double-strand Break Repair Telomeric D-loop Binding ISG15 Transferase Activity Ubiquitin Conjugating Enzyme Complex Regulation Of RNA Metabolic Process ATP Binding
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