MED28 and KLHL12

Number of citations of the paper that reports this interaction (PMID 16189514)
699

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		MED28	KLHL12
Gene Name		mediator complex subunit 28	kelch-like family member 12
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Membrane Mediator Complex Cortical Actin Cytoskeleton	Golgi Membrane Cytosol ER To Golgi Transport Vesicle Cul3-RING Ubiquitin Ligase Complex
	Molecular Function	Actin Binding Protein Binding	Protein Binding
	Biological Process	Transcription, DNA-templated Regulation Of Transcription, DNA-templated Stem Cell Maintenance Negative Regulation Of Smooth Muscle Cell Differentiation	Protein Monoubiquitination ER To Golgi Vesicle-mediated Transport Wnt Signaling Pathway COPII Vesicle Coating Negative Regulation Of Canonical Wnt Signaling Pathway
Pathways			misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling TCF dependent signaling in response to WNT RNF mutants show enhanced WNT signaling and proliferation XAV939 inhibits tankyrase, stabilizing AXIN degradation of DVL Signaling by Wnt Signaling by WNT in cancer
Drugs
Diseases
GWAS
Protein-Protein Interactions		14 interactors: FYN GRB2 KLHL12 LCK MAGEA11 MED30 MED8 MED9 NF2 PRMT6 PUF60 SPERT SRC USHBP1	39 interactors: ARAF ATXN1 BAG6 C1QTNF2 CARD10 CCBE1 COL8A1 CPSF6 CUL3 DGCR6 DRD4 DVL3 FGD2 FLNA GLYCTK INMT KLHL2 KLHL3 LNX1 MED28 MPP1 MRPL10 NDC80 PDGFRB PEF1 PRR13 RIT1 RPP25L SDCBP SNX20 SYNE4 TAOK2 TBC1D10C TTBK2 UBE2I VEGFB VTA1 WDYHV1 ZBP1
Entrez ID		80306	59349
HPRD ID		14381	13925
Ensembl ID			ENSG00000117153
Uniprot IDs		Q9H204	Q53G59
PDB IDs			2VPJ
Enriched GO Terms of Interacting Partners?		T Cell Costimulation Regulation Of Cell-cell Adhesion Peptidyl-tyrosine Autophosphorylation Epidermal Growth Factor Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Cellular Response To Fibroblast Growth Factor Stimulus Platelet Activation Response To Fibroblast Growth Factor Positive Regulation Of T Cell Activation Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of Homotypic Cell-cell Adhesion Neurotrophin Signaling Pathway Leukocyte Migration Viral Process Positive Regulation Of Cell-cell Adhesion Regulation Of Cell Adhesion Fc Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of T Cell Activation Positive Regulation Of Cell Activation Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide Cellular Response To Platelet-derived Growth Factor Stimulus Response To Platelet-derived Growth Factor Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell Adhesion Regulation Of Lymphocyte Activation Regulation Of Gene Expression Blood Coagulation Phosphatidylinositol-mediated Signaling Hemostasis Response To Peptide Hormone Cellular Response To Organonitrogen Compound Immune Response-regulating Signaling Pathway Regulation Of Cell Activation Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Response To Peptide Fc Receptor Mediated Stimulatory Signaling Pathway Regulation Of Defense Response To Virus By Virus Negative Regulation Of Signal Transduction Regulation Of Metabolic Process Cellular Response To Growth Factor Stimulus Cellular Response To Hormone Stimulus Protein Autophosphorylation Regulation Of Body Fluid Levels Negative Regulation Of Signaling Response To Mechanical Stimulus Response To Growth Factor	Regulation Of Signal Transduction Positive Regulation Of Signal Transduction Regulation Of Phosphorylation Regulation Of Signaling Regulation Of Intracellular Signal Transduction Regulation Of Phosphorus Metabolic Process Positive Regulation Of Intracellular Signal Transduction Regulation Of MAPK Cascade Positive Regulation Of MAPK Cascade Positive Regulation Of Phosphorylation Positive Regulation Of Protein Phosphorylation Positive Regulation Of Protein Metabolic Process Regulation Of Protein Metabolic Process Cellular Component Assembly Positive Regulation Of Transferase Activity Positive Regulation Of Metabolic Process Regulation Of Protein Phosphorylation Positive Regulation Of Cellular Protein Metabolic Process Anatomical Structure Morphogenesis Positive Regulation Of Protein Modification Process Positive Regulation Of Protein Serine/threonine Kinase Activity Positive Regulation Of Protein Kinase Activity Adenylate Cyclase-inhibiting Dopamine Receptor Signaling Pathway Positive Regulation Of Kinase Activity Regulation Of Protein Kinase Activity Regulation Of Cellular Protein Metabolic Process Regulation Of Kinase Activity Coronary Vasculature Development Actin Cytoskeleton Organization Positive Regulation Of MAP Kinase Activity Positive Regulation Of Cellular Metabolic Process Intracellular Signal Transduction Chromosome Segregation Actin Filament-based Process Positive Regulation Of Catalytic Activity Anatomical Structure Development Cellular Protein Modification Process Activation Of Protein Kinase Activity Positive Regulation Of JNK Cascade Ubiquitin-dependent Protein Catabolic Process Anatomical Structure Formation Involved In Morphogenesis Modification-dependent Protein Catabolic Process Cell Projection Assembly Regulation Of MAP Kinase Activity Positive Regulation Of Cell Division Positive Regulation Of Stress-activated MAPK Cascade Positive Regulation Of Stress-activated Protein Kinase Signaling Cascade Regulation Of Chemotaxis Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Mitotic Nuclear Division
Tagcloud ?		aspect blocked concomitant construct cytoskeleton dead ectopic eg exhibits exogenous grb2 interfering invasion magicin map2k1 mediator mek1 merlin metalloproteinase migration mmp2 potentiated presumably recovered reinforcing repressor rescued stimulate suppression
Tagcloud (Difference) ?		aspect blocked concomitant construct cytoskeleton dead ectopic eg exhibits exogenous grb2 interfering invasion magicin map2k1 mediator mek1 merlin metalloproteinase migration mmp2 potentiated presumably recovered reinforcing repressor rescued stimulate suppression
Tagcloud (Intersection) ?