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EFHC2 and EGLN3
Number of citations of the paper that reports this interaction (PubMedID
25416956
)
56
Data Source:
BioGRID
(two hybrid)
EFHC2
EGLN3
Description
EF-hand domain containing 2
egl-9 family hypoxia inducible factor 3
Image
No pdb structure
GO Annotations
Cellular Component
Cytoplasm
Cytoskeleton
Microtubule
Axonemal Microtubule
Cilium
Motile Cilium
Ciliary Basal Body
Sperm Flagellum
Cell Projection
Axonemal A Tubule Inner Sheath
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Molecular Function
Calcium Ion Binding
Protein Binding
Iron Ion Binding
Protein Binding
Ferrous Iron Binding
Oxidoreductase Activity
Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen
2-oxoglutarate-dependent Dioxygenase Activity
L-ascorbic Acid Binding
Peptidyl-proline 4-dioxygenase Activity
Metal Ion Binding
Dioxygenase Activity
Hypoxia-inducible Factor-proline Dioxygenase Activity
Biological Process
Regulation Of Neuron Projection Development
Flagellated Sperm Motility
Cellular Response To Leukemia Inhibitory Factor
Apoptotic Process
DNA Damage Response
Protein Hydroxylation
Regulation Of Neuron Apoptotic Process
Cellular Response To Hypoxia
Pathways
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
Drugs
Ascorbic acid
Roxadustat
Daprodustat
Vadadustat
Diseases
GWAS
Body mass index and diastolic blood pressure (bivariate analysis) (
33539483
)
Glaucoma (primary open-angle) (
33627673
)
Mean arterial pressure (
29403010
)
Alzheimer's disease (late onset) (
30820047
)
Daytime sleep phenotypes (
27126917
)
Hematocrit (
27863252
32888494
)
Hemoglobin (
32888494
)
Iron status biomarkers (ferritin levels) (
33536631
)
Red blood cell count (
32888494
)
Interacting Genes
100 interacting genes:
-
AASDHPPT
ARHGEF5
ARMC7
ATOSB
CABP2
CACNB4
CARD9
CCDC102B
CCDC120
CCDC13
CCDC57
CCHCR1
CCNG2
CDKN2A
CLIC3
COPE
CPNE2
CPNE7
CYFIP1
DCLK1
DDX6
DGCR6
DRC7
EDC3
EFHC1
EGLN3
EMD
ENKD1
ESRRG
EXOC8
EXOSC5
FAM107A
FAM124B
FAM221B
FBXL19
GEM
GLYCTK
GOLGA1
GPKOW
GRB2
GYS1
HDAC4
HGS
HNRNPLL
INPP5J
JAKMIP2
KANK2
KCTD7
KIF9
L3MBTL2
LMNB2
LMO2
LNX1
LONRF1
MAGOHB
MAPK9
MID2
MISP
MTCL2
MYLIP
MYO5B
NCDN
NCK2
NDOR1
NEK6
NFKBID
NME7
NR3C1
PBLD
PHF1
PIBF1
PICK1
PLOD3
POLR1C
PRPF18
PTK6
QARS1
RAD51D
RCOR3
RECK
RHOBTB3
RUNX1T1
SNRNP25
SPATA18
SPG21
STK16
TBC1D1
TBC1D22B
TEKT4
TRIM42
TRIM50
TSSK3
TUBGCP4
TXK
U2AF1
USP2
ZBTB16
ZFHX3
ZZZ3
40 interacting genes:
ABI2
ADRB2
ATF4
CDC20
CFTR
CTBP2
DUSP7
EFHC2
EPAS1
EPOR
FAM168B
FOXJ2
GSC2
HIF1A
HIF3A
IK
IKBKG
IKZF3
LDB2
LNX1
MAPK1
MAPK7
MDM2
NCAPH2
NTAQ1
OS9
PKM
PLEKHA2
PRPF19
RBBP8NL
SERTAD1
SIAH2
SUMO1
SUMO2
SUMO3
TP53
TTC23L
WDR83
ZC2HC1A
ZNF655
Entrez ID
80258
112399
HPRD ID
06540
06972
Ensembl ID
ENSG00000183690
ENSG00000129521
Uniprot IDs
Q5JST6
B3KVT0
F8W1G2
Q3T1B0
Q9H6Z9
PDB IDs
2Z13
2Z14
7UNG
8J07
Enriched GO Terms of Interacting Partners
?
Cytoplasm
Protein Binding
Protein Phosphorylation
Cytoskeleton
Regulation Of Podosome Assembly
Phosphorylation
Centrosome
Nucleus
Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Transcription By RNA Polymerase II
Nuclear Speck
Cellular Response To Hypoxia
Cellular Response To Decreased Oxygen Levels
Regulation Of Protein Metabolic Process
Regulation Of DNA-templated Transcription
Regulation Of RNA Metabolic Process
Regulation Of RNA Biosynthetic Process
Intracellular Oxygen Homeostasis
Cellular Response To Oxygen Levels
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Response To Hypoxia
Negative Regulation Of Intrinsic Apoptotic Signaling Pathway
Regulation Of Intrinsic Apoptotic Signaling Pathway
Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process
Ubiquitin Protein Ligase Binding
Protein Sumoylation
PML Body
Protein Tag Activity
Regulation Of Nucleobase-containing Compound Metabolic Process
Response To Decreased Oxygen Levels
Positive Regulation Of RNA Metabolic Process
Cellular Response To Stress
Response To Oxygen Levels
Positive Regulation Of RNA Biosynthetic Process
Positive Regulation Of DNA-templated Transcription
Negative Regulation Of Apoptotic Signaling Pathway
Positive Regulation Of Proteolysis Involved In Protein Catabolic Process
Cellular Response To Actinomycin D
Transcription Regulator Complex
Cytoplasm
Protein Modification By Small Protein Conjugation
Positive Regulation Of Macromolecule Metabolic Process
Identical Protein Binding
Response To Actinomycin D
Ubiquitin-like Protein Ligase Binding
Regulation Of Apoptotic Signaling Pathway
Enzyme Binding
Embryonic Organ Development
Intracellular Signal Transduction
Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Protein Binding
Cellular Response To UV-C
Regulation Of Primary Metabolic Process
Regulation Of Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Biosynthetic Process
Protein Modification Process
Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway
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Tagcloud (Difference)
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Tagcloud (Intersection)
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