EFHC2 and CACNB4

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid, two hybrid)

		EFHC2	CACNB4
Description		EF-hand domain containing 2	calcium voltage-gated channel auxiliary subunit beta 4
Image
GO Annotations	Cellular Component	Cytoplasm Cytoskeleton Microtubule Axonemal Microtubule Cilium Motile Cilium Ciliary Basal Body Sperm Flagellum Cell Projection Axonemal A Tubule Inner Sheath	Cytosol Plasma Membrane Voltage-gated Calcium Channel Complex Cytoplasmic Side Of Plasma Membrane Nuclear Speck Monoatomic Ion Channel Complex Synapse Presynapse Glutamatergic Synapse
	Molecular Function	Calcium Ion Binding Protein Binding	Voltage-gated Calcium Channel Activity Calcium Channel Regulator Activity Calcium Channel Activity Protein Binding Protein Kinase Binding Voltage-gated Calcium Channel Activity Involved In Regulation Of Presynaptic Cytosolic Calcium Levels
	Biological Process	Regulation Of Neuron Projection Development Flagellated Sperm Motility Cellular Response To Leukemia Inhibitory Factor	Monoatomic Ion Transport Calcium Ion Transport Gamma-aminobutyric Acid Signaling Pathway Chemical Synaptic Transmission Neuromuscular Junction Development Adult Walking Behavior Negative Regulation Of Cell Population Proliferation Gamma-aminobutyric Acid Secretion Neuronal Action Potential Propagation Monoatomic Ion Transmembrane Transport Synaptic Transmission, Glutamatergic Regulation Of Membrane Potential CAMP Metabolic Process Spleen Development Thymus Development Peyer's Patch Development T Cell Receptor Signaling Pathway Nervous System Process Detection Of Light Stimulus Involved In Visual Perception Muscle Cell Development Calcium Ion Transmembrane Transport Regulation Of Presynaptic Cytosolic Calcium Ion Concentration Positive Regulation Of Protein Localization To Nucleolus Cellular Response To Leukemia Inhibitory Factor Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Synaptic Vesicle Exocytosis
Pathways			Presynaptic depolarization and calcium channel opening NCAM1 interactions
Drugs			Ergocalciferol Enflurane Ranolazine Phenytoin Topiramate Nimodipine Spironolactone Nicardipine Magnesium sulfate Verapamil Levomenthol Nitrendipine Miconazole Amiodarone Mibefradil Dronedarone Nilvadipine Drotaverine Trimebutine Benidipine Cilnidipine Efonidipine Efonidipine Lacidipine Manidipine Butamben Bioallethrin Bioallethrin Fish oil
Diseases			Episodic ataxias Idiopathic generalied epilepsies (IGEs), including: Childhood absence epilepsy (CAE); Juvenile absence epilepsy (JAE); Juvenile myoclonic epilepsy (JME); Epilepsy with generalized tonic-clonic seizures alone
GWAS		Body mass index and diastolic blood pressure (bivariate analysis) ( 33539483) Glaucoma (primary open-angle) ( 33627673) Mean arterial pressure ( 29403010)	Adverse response to chemotherapy in breast cancer (alopecia) ( 24025145) Idiopathic dilated cardiomyopathy ( 29495422) Response to cognitive-behavioural therapy in anxiety disorder ( 26989097)
Interacting Genes		100 interacting genes: - AASDHPPT ARHGEF5 ARMC7 ATOSB CABP2 CACNB4 CARD9 CCDC102B CCDC120 CCDC13 CCDC57 CCHCR1 CCNG2 CDKN2A CLIC3 COPE CPNE2 CPNE7 CYFIP1 DCLK1 DDX6 DGCR6 DRC7 EDC3 EFHC1 EGLN3 EMD ENKD1 ESRRG EXOC8 EXOSC5 FAM107A FAM124B FAM221B FBXL19 GEM GLYCTK GOLGA1 GPKOW GRB2 GYS1 HDAC4 HGS HNRNPLL INPP5J JAKMIP2 KANK2 KCTD7 KIF9 L3MBTL2 LMNB2 LMO2 LNX1 LONRF1 MAGOHB MAPK9 MID2 MISP MTCL2 MYLIP MYO5B NCDN NCK2 NDOR1 NEK6 NFKBID NME7 NR3C1 PBLD PHF1 PIBF1 PICK1 PLOD3 POLR1C PRPF18 PTK6 QARS1 RAD51D RCOR3 RECK RHOBTB3 RUNX1T1 SNRNP25 SPATA18 SPG21 STK16 TBC1D1 TBC1D22B TEKT4 TRIM42 TRIM50 TSSK3 TUBGCP4 TXK U2AF1 USP2 ZBTB16 ZFHX3 ZZZ3	13 interacting genes: CACNA1A CBX3 CCDC102B CTBP2 EFHC2 FASLG MAP1A MED31 PTN REM1 SNCA SYT1 TBL3
Entrez ID		80258	785
HPRD ID		06540	09057
Ensembl ID		ENSG00000183690	ENSG00000182389
Uniprot IDs		Q5JST6	A0A1B0GTK1 A0A1B0GTP5 A0A1B0GTX8 E7DBM8 H0Y476 O00305
PDB IDs		2Z13 2Z14 7UNG 8J07	2D46
Enriched GO Terms of Interacting Partners?		Cytoplasm Protein Binding Protein Phosphorylation Cytoskeleton Regulation Of Podosome Assembly Phosphorylation Centrosome	Modulation Of Chemical Synaptic Transmission Positive Regulation Of Neurotransmitter Secretion Positive Regulation Of Vesicle Fusion Regulation Of Dopamine Secretion Syntaxin Binding Synapse Transcription Coregulator Binding Regulation Of Synaptic Plasticity Dendrite Development Tau Protein Binding Response To Desipramine Negative Regulation Of Norepinephrine Uptake Phospholipase D Inhibitor Activity Regulation Of Vesicle Fusion Positive Regulation Of SNARE Complex Assembly Regulation Of Catecholamine Secretion Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Neurotransmitter Secretion Synaptic Vesicle Exocytosis Fast, Calcium Ion-dependent Exocytosis Of Neurotransmitter Synchronous Neurotransmitter Secretion Cell-cell Signaling Signaling Cell Communication Positive Regulation Of Phosphatidylserine Exposure On Apoptotic Cell Surface Chemical Synaptic Transmission Retrograde Axonal Protein Transport Primary Dendrite Dendrite Regeneration SNARE Binding Regulation Of Norepinephrine Uptake Regulation Of Amine Transport Negative Regulation Of Mitochondrial Electron Transport, NADH To Ubiquinone Positive Regulation Of Hydrogen Peroxide Catabolic Process Syntaxin-3 Binding Calcium Ion Transmembrane Import Into Cytosol Retinal Cell Programmed Cell Death Trans-synaptic Signaling Synaptic Signaling Neuronal Cell Body Dendritic Branch Dendritic Microtubule Ossification Involved In Bone Remodeling Negative Regulation Of Serotonin Uptake Positive Regulation Of Exocytosis Transporter Regulator Activity Regulation Of Neurotransmitter Secretion Vesicle-mediated Transport In Synapse Negative Regulation Of Chaperone-mediated Autophagy Positive Regulation Of Calcium Ion-dependent Exocytosis Of Neurotransmitter
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