EFHC2 and NCDN

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid, two hybrid)

		EFHC2	NCDN
Description		EF-hand domain containing 2	neurochondrin
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytoskeleton Microtubule Axonemal Microtubule Cilium Motile Cilium Ciliary Basal Body Sperm Flagellum Cell Projection Axonemal A Tubule Inner Sheath	Nucleus Cytoplasm Endosome Cytosol Endosome Membrane Membrane Axon Dendrite Cell Projection Neuron Projection Neuronal Cell Body Perikaryon Synapse Postsynapse Glutamatergic Synapse
	Molecular Function	Calcium Ion Binding Protein Binding	Protein Binding
	Biological Process	Regulation Of Neuron Projection Development Flagellated Sperm Motility Cellular Response To Leukemia Inhibitory Factor	Neuron Projection Development Bone Resorption Regulation Of Neuronal Synaptic Plasticity Regulation Of Postsynaptic Neurotransmitter Receptor Internalization
Pathways
Drugs
Diseases
GWAS		Body mass index and diastolic blood pressure (bivariate analysis) ( 33539483) Glaucoma (primary open-angle) ( 33627673) Mean arterial pressure ( 29403010)
Interacting Genes		100 interacting genes: - AASDHPPT ARHGEF5 ARMC7 ATOSB CABP2 CACNB4 CARD9 CCDC102B CCDC120 CCDC13 CCDC57 CCHCR1 CCNG2 CDKN2A CLIC3 COPE CPNE2 CPNE7 CYFIP1 DCLK1 DDX6 DGCR6 DRC7 EDC3 EFHC1 EGLN3 EMD ENKD1 ESRRG EXOC8 EXOSC5 FAM107A FAM124B FAM221B FBXL19 GEM GLYCTK GOLGA1 GPKOW GRB2 GYS1 HDAC4 HGS HNRNPLL INPP5J JAKMIP2 KANK2 KCTD7 KIF9 L3MBTL2 LMNB2 LMO2 LNX1 LONRF1 MAGOHB MAPK9 MID2 MISP MTCL2 MYLIP MYO5B NCDN NCK2 NDOR1 NEK6 NFKBID NME7 NR3C1 PBLD PHF1 PIBF1 PICK1 PLOD3 POLR1C PRPF18 PTK6 QARS1 RAD51D RCOR3 RECK RHOBTB3 RUNX1T1 SNRNP25 SPATA18 SPG21 STK16 TBC1D1 TBC1D22B TEKT4 TRIM42 TRIM50 TSSK3 TUBGCP4 TXK U2AF1 USP2 ZBTB16 ZFHX3 ZZZ3	13 interacting genes: A2M ACD EFHC2 KRT75 LYST PAX6 POT1 PREX1 SEMA4C TINF2 TLE5 ZBED1 ZNF398
Entrez ID		80258	23154
HPRD ID		06540	10530
Ensembl ID		ENSG00000183690	ENSG00000020129
Uniprot IDs		Q5JST6	Q9UBB6
PDB IDs		2Z13 2Z14 7UNG 8J07
Enriched GO Terms of Interacting Partners?		Cytoplasm Protein Binding Protein Phosphorylation Cytoskeleton Regulation Of Podosome Assembly Phosphorylation Centrosome	Telomere Assembly Shelterin Complex Nuclear Telomere Cap Complex Telomere Capping Negative Regulation Of Telomere Maintenance Via Telomerase Telomeric DNA Binding Negative Regulation Of DNA Biosynthetic Process Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Negative Regulation Of Telomere Maintenance Regulation Of Telomere Maintenance Via Telomerase Regulation Of Telomere Maintenance Via Telomere Lengthening Telomerase Inhibitor Activity Establishment Of Protein Localization To Telomere Positive Regulation Of Telomere Maintenance Negative Regulation Of Chromosome Organization Protein Localization To Chromosome, Telomeric Region Regulation Of DNA Biosynthetic Process Telomere Maintenance Positive Regulation Of Chromosome Organization Regulation Of Telomere Maintenance Cell Motility Telomere Maintenance Via Telomerase Telomere Organization Negative Regulation Of DNA Metabolic Process RNA-templated DNA Biosynthetic Process Telomere Maintenance Via Telomere Lengthening Chromosome, Telomeric Region Cell Migration Leukocyte Migration Forebrain-midbrain Boundary Formation Pancreatic A Cell Development Protein Autosumoylation Positive Regulation Of DNA Strand Elongation Positive Regulation Of Telomeric D-loop Disassembly G-rich Single-stranded DNA Binding Regulation Of Chromosome Organization Positive Regulation Of DNA Metabolic Process Negative Regulation Of Complement Activation, Lectin Pathway Mast Cell Secretory Granule Organization Positive Regulation Of Telomeric Loop Disassembly Perinucleolar Chromocenter Interleukin-8 Binding Chemotaxis Habenula Development Pallium Development DNA Biosynthetic Process 8-hydroxy-2'-deoxyguanosine DNA Binding Telomeric G-quadruplex DNA Binding Chromosome Organization Locomotion
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